Drug Study

Name of Drug Indication/s Contraindication/s Mechanism of Side Effect/s Adverse Effect/s Nursing Action/s
Action

Generic Name: Treatment of the -Contraindicated in: • injection site

cefepime following infections Hypersensitivity to Binds to the reactions (pain, - Assess patient for
CNS:
caused by cephalosporins; bacterial cell wall redness, swelling, infection (vital signs;
susceptible Serious membrane, soreness, or skin -SEIZURES q risk in renal appearance of
organisms: hypersensitivity causing cell death. rash), impairment), wound, sputum,
Brand Name:
Uncomplicated skin to penicillins. urine, and
Maxipime -encephalopathy,
and skin structure •stomach pain, stool; WBC) at
infections, Bone -Use Cautiously in: -headache. beginning of and
and joint infections, Renal impairment (p • nausea, throughout therapy.
Therapeutic GI:
Uncomplicated dosing/ q
Classification:
and complicated dosing interval •vomiting, - -Before initiating
Cephalosporin urinary tract recommended PSEUDOMEMBRANOUS therapy, obtain a
infections, if CCr 60 mL/min); •loss of appetite, COLITIS history to determine
Respiratory tract History of GI previous use of and
infections, disease, especially •diarrhea -diarrhea, reactions to
Dosage/route:
Cefepime (as HCl) Complicated colitis; Patients with -nausea, penicillins or
500mg, 1g, 2g; pwd intra-abdominal hepaticdys-function •headache, cephalosporins.
infections (with or poor nutritional -vomiting.
for IV infusion or IM
inj after metronidazole), status (may be at Derm: -Obtain specimens
reconstitution. Septicemia. Empiric q risk of bleeding); for culture and
treatment of Geriatric patients -rashes sensitivity before
febrile neutropenic (dose adjustment -pruritis, initiating therapy.
patients. due to age-related First dose
P in renal function -urticaria. may be given before
may be necessary); Hemat: receiving results.
OB, Lactation:
Pregnancy and -bleeding, -Observe patient for
lactation (safety not --eosinophilia, signs and symptoms
established) of anaphylaxis (rash,
-hemolytic anemia, pruritus,
- neutropenia, laryngeal edema,
wheezing).
- thrombocytopenia. -Discontinue the drug
Local: and notify healthcare
professional
-pain at IM site, immediately if these
symptoms occur.
-phlebitis at IV site.
- Keep epinephrine,
Misc:
an antihistamine, and
allergic reactions resuscitation
including equipment close by
in the event
ANAPHYLAXIS
of an anaphylactic
superinfection, fever. reaction.

-Monitor bowel
function. Diarrhea,
abdominal cramping,
fever, and
bloody stools should
be reported to health
care professional
promptly as a sign of
pseudomembranous
colitis. May begin up
to several weeks
following cessation of
therapy.

-Lab Test
Considerations:
May cause positive
results for Coombs’
test in pa-
tients receiving high
doses or in neonates
whose mothers were
given cephalospo-
rins before delivery.