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segura@quim.ucm.es; jorduna@unizar.es
Received July 4, 2010
In this article we describe novel synthetic strategies toward well-defined disubstituted conjugated hexaaza-
triphenylene (HAT) derivatives. The systems are designed as novel V-shaped chromophores displaying C2
symmetry suitable for nonlinear optical investigations. Different donor moieties and linkers have been used in
order to tune the electrochemical properties as well as the absorption spectra of the novel HAT derivatives.
μβ values as high as 1010 10-48 esu have been obtained for a derivative containing the electron-rich dibutyl-
amino moiety. Theoretical calculations have been performed showing a reasonable agreement with the
experimental results and supporting the two-dimensional NLO character of these chromophores.
7542 J. Org. Chem. 2010, 75, 7542–7549 Published on Web 10/25/2010 DOI: 10.1021/jo101311v
r 2010 American Chemical Society
Ju
arez et al.
JOC Article
like liquid crystal behavior,8-16 electron mobility,17-20 self- CHART 1. HATs Studied in the Present Paper
assembling,21-28 and redox properties.29-31 HATs have also
been used to modify and control the color of mesoporous
silica32 and have been included in organic light emitting
devices (OLEDs).33,34
Nonlinear optical (NLO) properties of HAT derivatives
have been treated only once in the literature and only refer to
some completely symmetric (trigonal) derivatives and its
metal complexes with Cuþ.35 These molecules showed an
octupolar NLO response.
Most of the HAT derivatives in the previous references
involve trigonal molecules and only a few papers describe
SCHEME 2. Synthesis of Key Products 11 and 12 and Final SCHEME 4. Final Obtention of Alkynyl-Linked HATs 3 and 4
Obtention of Alkenyl-Linked Compounds 1 and 2
(42) Rogers, D. Z. J. Org. Chem. 1986, 51, 3904–3905. (44) Lydon, D. P.; Albesa-Jove, D.; Shearman, G. C.; Seddon, J. M.;
(43) Moucheron, C.; Mesmaeker, A. K. D.; Choua, S. Inorg. Chem. 1997, Howard, J. A. K.; Marder, T. B.; Low, P. J. Liq. Cryst. 2008, 35, 119–132.
36, 584–592. (45) Miller, J. J.; Marsden, J. A.; Haley, M. M. Synlett 2004, 165–168.
FIGURE 3. Side view of the B3P86/6-31G*optimized C2 geometry (the optimization was constrained) of compound 3.
compd EHOMO ELUMO sym. E01 μ01 Δμ01 βzzz(0) βzyy(0) μβ(0)
1 -5.81 -2.73 A 2.71 5.8 11.9 30 26 114
B 2.87 7.3 10.3
B 3.18 4.6 10.3
A 3.40 8.2 11.3
2 -5.31 -2.49 A 2.48 5.8 9.6 51 46 596
B 2.59 7.2 12.7
B 2.80 5.7 12.5
A 3.02 8.5 14.4
3 -6.12 -2.78 B 2.97 5.5 12.0 39 16 201
A 2.97 5.4 10.1
B 3.35 2.4 12.0
A 3.34 8.3 11.3
4 -5.55 -2.56 B 2.64 5.6 15.4 66 28 731
A 2.68 4.9 13.9
B 2.94 3.4 16.5
A 3.04 9.8 17.1
a
B3P86/6-31G*, energies are in eV, dipoles in Debye. bHF/6-31G*, hyperpolarizabilities β in 10-30 esu and μβ in 10-48 esu.
dichloromethane. Similar μβ values, around 1000 10-48 than that of their acetylenic analogues (compare 1 to 3
esu, were obtained for dibutylamino derivatives 2 and 4 and 2 to 4) in good agreement with the lower oxidation and
(1010(50) 10-48 and 970(50) 10-48 esu, respectively). more negative reduction potential of 1 compared to 3 and
As expected from the relative donor strength of substitu- 2 compared to 4.
ents, much lower response was observed for hexyloxy The absorption spectra calculated by TD-DFT (time-
benzene derivatives. μβ=200(30)10-48 esu was obtained dependent density functional theory) predict the lowest
for compound 3 whereas the nonlinear optical response of excitation energies with an error of 0.24 eV for compound
1 was too small to be reliably determined. For the sake of 1 and less than 0.1 eV for 2-4, which is a reasonable error
comparison, Disperse Red 1, a common benchmark of for this method. We have previously mentioned that re-
organic NLO-Chromophores, gives a μβ(0) value of ca. placement of a double by a triple bond decreases the energy
480 10-48 esu in the same experimental conditions. of both the HOMO and the LUMO; according to our
2.4. Theoretical Calculations. The molecular geometries of calculations this effect is more important on the HOMO
compounds 1-4 have been optimized constrained to C2 and therefore causes an increased HOMO-LUMO gap
symmetry by using the hybrid B3P86 DFT (density func- that results in a hypsochromic shift. In a similar way,
tional theory) method and the 6-31G* basis set. The π sys- on passing from hexyloxy to dibutylamino substituent the
tems in ethylenic compounds 1 and 2 are completely planar, HOMO energy increases by 0.50 eV (from 1 to 2) or 0.57 eV
but this is not the case for acetylenic chromophores 3 and 4 (from 3 to 4) while the LUMO energy increases by 0.24 and 0.22
(see Figure 3): The folding angle defined by one of the sub- eV, respectively, and therefore there is a decreased HOMO-
stituents, the HAT moiety, and the other substituent is 3.6. -LUMO gap and the absorption of dibuthylamino derivatives
Furthermore, the substituted phenyl rings are twisted by 15 is red-shifted with respect to their hexyloxy analogues.
(3) or 13.4 (4) with respect to the HAT moiety. On the basis Molecules 1-4 belong to the so-called V-shaped (or
of structural parameters, a better π delocalization is expected Λ-shaped) chromophores47 displaying C2 symmetry. Making
for ethylenic than for acetylenic compounds. use of the standard orientation, we assume that the mole-
The properties of compounds 1-4 studied by theoretical cule lies on the yz plane with z along the symmetry axis (see
methods are gathered in Table 3. While it is not possible to Figure 4). The molecular hyperpolarizability is dominated
match precisely theoretical calculations performed on iso- by two tensor components: βzzz and βzyy (the off-diagonal
lated molecules in the gas phase to experimental measure- component) and the EFISH technique samples μβ values
ments performed in solution, the results of the calculations contributed from both tensor components:
allow a qualitative description of the observed trends. It can μβ ¼ μβz ¼ μðβzzz þ βzyy Þ
be seen that the HOMO energy is higher for dialkylamino
compounds than for their analogous alkoxy compounds A simple model to study the NLO properties describes
by 0.50-0.57 eV thus explaining the less positive oxida- C2 chromophores as the combination of two isolated
tion potential of the former. In a similar way the HOMO
and LUMO energies of ethylenic compounds are higher (47) Wolff, J. J.; Wortmann, R. J. Prakt. Chem. 1998, 340, 99–111.
HAT moiety with different moieties to further tune their CDCl3) δ (ppm) 160.4, 150.9, 146.7, 154.8, 142.6, 141.9, 139.7,
nonlinear optical response. 139.3, 129.4, 128.9, 119.5, 114.8, 68.1, 31.6, 29.2, 25.7, 22.6, 14.0.
FTIR (KBr) ν (cm-1) 2929, 2858, 1602, 1509, 1249, 1172, 754.
4. Experimental Section MS (EI) m/z (%) 638 [M]•þ (100), 553 (25). Elemental Anal.
Calcd: C (75.21), H (6.63), N (13.16). Found: C (75.32), H (6.58),
2,3-Bis(bromomethyl)hexaazatriphenylene (11). To a stirred N (13.18). Mp 237-239 C.
suspension of diamine (9) (673 mg, 3.17 mmol) in absolute HAT-Alkene(NBu2)2 (2): A red solid was obtained (29 mg,
ethanol (70 mL) at 0 C under argon atmosphere was added 25%). 1H NMR (400 MHz, CDCl3) δ (ppm) 9.25 (d, 2H, J = 2.2
1,4-dibromobutanedione (10) (1.161 g, 4.76 mmol). The suspen- Hz), 9.17 (d, 2H, J = 2.2 Hz), 8.24 (d, 2H, J = 15.5 Hz), 7.63
sion was stirred for 5 h at that temperature, then the solvent was (d, 4H, J = 9.0 Hz), 7.53 (d, 2H, J = 15.5 Hz), 6.67 (d, 4H, J =
removed under vacuum. The crude product was purified by 9.0 Hz), 3.34 (t, 8H, J = 8.3 Hz), 1.70-1.52 (m, 8H), 1.49-1.22
column chromatography (CH2Cl2 until unchanged butanedione (m, 8H), 0.98 (t, 12H, J = 7 Hz). 13C NMR (100 MHz, CDCl3)
was eluted then CH2Cl2 with 2% MeOH). A pale-yellow solid δ (ppm) 151.6, 149.1, 146.6, 145.4, 142.9, 141.7, 140.2, 138.8,
were isolated (1.265 g, 95%). 1H NMR (200 MHz, CDCl3) 133.3, 129.7, 123.6, 116.5, 111.4, 50.8, 29.5, 20.3, 13.9. FTIR
δ (ppm) 9.33 (d, 2H, J = 2.0 Hz), 2.29 (d, 2H, J = 2.0 Hz), 5.18 (KBr) ν (cm-1) 2958, 2931, 1598, 1522, 1502, 1368, 1183. MS
(s, 4H). 13C NMR (50 MHz, CDCl3) δ (ppm) 154.1, 147.2, 147.1, (EI) m/z (%) 692 [M]•þ (21), 640 (88), 368 (62), 449 (91), 107
142.5, 141.7, 140.8, 29.6. FTIR (KBr) ν (cm-1) 3030, 2970, 2923, (100). Elemental Anal. Calcd: C (76.27), H (7.56), N (16.17).
1631, 1380, 1092. MS (EI) m/z (%) 418 [M]•þ (3), 262 (100), 221 Found: C (76.18), H (7.63), N (16.23). Mp 184 C.
(64). Elemental Anal. Calcd: C (40.03), H (1.92), N (20.01). General Procedure for the Synthesis of 17 and 18. To a solution
Found: C (40.19), H (2.05), N (19.87). Mp >170 C dec. under argon atmosphere of the corresponding iododerivative
2,3-Bis((dimethylphosphonate)methyl)hexaazatriphenylene (12). (15 or 16) (6.58 mmol) and triisopropylsilylacetylene (6.58 mmol)
A suspension of 11 (161 mg, 0.38 mmol) in trimethylphosphite in diisopropylamine (20 mL) were added [PdCl2(PPh3)2] (230 mg,
(15 mL) under Argon atmosphere was heated to reflux for 3 h. 0.33 mmol) and CuI (106 mg, 0.56 mmol). The suspension was
After this time an excess of solvent was distilled and the residue was stirred at room temperature for 16 h. After this time 50 mL of
purified by column chromatography (CH2Cl2: MeOH 9:1). The hexane was added and the reaction was filtered over a plug of
product was obtained as a pale-brown solid (102 mg, 56%). 1H silica with dichloromethane as eluent. The solvent was then
NMR (400 MHz, CDCl3) δ (ppm) 9.28 (d, 2H, J = 2.0 Hz), 9.25 removed and the residue purified by column chromatography
(d, 2H, J = 2.0 Hz), 4.30 (d, 4H, J = 22.0 Hz), 3.80 (d, 12H, J = (silica gel, hexane).
11.0 Hz). 13C NMR (100 MHz, CDCl3) δ (ppm) 151.5, 146.9, ((4-(Hexyloxy)phenyl)ethynyl)triisopropylsilane (17): The prod-
146.6, 142.2, 142.0, 140.1, 53.2, 34.2 (d, CH2-P, J = 132.0). FTIR uct was obtained as a colorless oil (1.975 g, 84%). 1H NMR (400
(KBr) ν (cm-1) 2958, 1635, 1542, 1239, 1030. MS (EI) m/z (%) 478 MHz, CDCl3) δ (ppm) 7.40 (d, 2H, J = 9.1 Hz), 6.80 (d, 2H, J=
[M]•þ (100), 384 (30), 275 (33), 94 (36). Elemental Anal. Calcd: C 9.1 Hz), 3.94 (t, 2H, J=6.6 Hz), 1.77 (quint, 2H, J=6.6 Hz), 1.45
(45.20), H (4.21), N (17.57). Found: C (45.02), H (3.98), N (17.65). (m, 2H), 1.33 (m, 4H), 1.12 (s, 18H), 1.09 (s, 3H), 0.9 (t, 3H, J=
Mp >220 C dec. 7.0 Hz). 13C NMR (100 MHz, CDCl3) δ (ppm) 159.1, 133.4,
4-Hexyloxybenzaldehyde (13). In a round-bottomed flask 115.4, 114.2, 107.16, 88.4, 68.0, 31.5, 29.1, 25.6, 18.7, 14.0, 11.3.
p-hydroxybenzaldehyde (2 g, 16 mmol), hexyl bromide (3.46 g, FTIR (CH2Cl2) ν (cm-1) 2938, 2864, 2153, 1605, 1506, 1246, 882,
21 mmol), and K2CO3 (2.94 g, 21 mmol) were dissolved in DMF 831, 782. MS (ESI) m/z 381.3 [M þ Na]•þ. Elemental Anal. Calcd:
(50 mL). The solution was heated to reflux for 16 h and then C (77.03), H (10.68). Found: C (76.99), H (10.75).
allowed to cool to room temperature. The reaction was poured N,N-Dibutyl-4-((triisopropylsilyl)ethynyl)aniline (18): The
into water and extracted with dichloromethane. The organic product was obtained as a light yellow oil (2.32 g, quantitative).
phase was dried over MgSO4 and filtered and the solvent was 1
H NMR (400 MHz, CDCl3) δ (ppm)=7.31 (d, 2H, J=9.0 Hz),
removed in vacuo. The oil obtained was purified by column 6.52 (d, 2H, J=9.0 Hz), 3.26 (t, 4H, J=7.6 Hz), 1.54 (quint, 4H,
chromatography (silica gel), using a mixture of hexane:ethyl J=7.6 Hz), 1.33 (sext, 4H, J=7.7 Hz), 1.16 - 1.06 (m, 21H),
acetate (7: 3) as eluent, to yield 2.877 g of product as a pale 0.94 (t, 6H, J=7.3 Hz). 13C NMR (100 MHz, CDCl3) δ (ppm)
yellow oil (87%). 1H NMR (400 MHz, CDCl3) δ (ppm) 9.87 147.9, 133.3, 111.1, 109.3, 108.7, 86.8, 50.7, 29.4, 20.3, 18.7,
(s. 1H), 7.82 (d, 2H, J = 8.4 Hz), 6.99 (d, 2H, J = 8.4 Hz), 4.04 13.9, 11.5. FTIR (CH2Cl2) ν (cm-1) 2939, 2863, 2144, 1605,
(t, 2H, J = 6.5 Hz), 1.81 (m, 2H), 1.47 (m, 2H), 1.34 (m, 4H), 1514, 1461, 1366, 1184. MS (ESI) m/z 408.3 [M þ Na]•þ.
0.91 (t, 3H, J = 6.9 Hz). 13C NMR (100 MHz, CDCl3) δ (ppm) Elemental Anal. Calcd: C (77.85), H (11.24), N (3.63). Found:
190.8, 164.2, 131.9, 129.7, 114.7, 68.4, 31.5, 29.0, 25.6, 22.6, 14.0. C (78.02), H (11.11), N (3.51).
FTIR (CH2Cl2) ν (cm-1) 2931, 2863, 2733, 1691, 1601, 1509, General Procedure for the Synthesis of 21 and 2253. Under
1310, 1256, 1159, 1015, 832. MS (ESI) m/z 229.0 [M þ Na]•þ. argon atmosphere the corresponding unprotected alkyne (19 or
Elemental Anal. Calcd: C (75.69), H (8.80). Found: C (75.75), 20) (3.96 mmol) was dissolved in anhydrous THF (15 mL) at
H (8.63). 0 C. To this solution was added butyllithium (3.96 mmol, 1.6 M
General Procedure for the Synthesis of 1 and 2. A suspension of in hexanes) slowly and the resulting solution was stirred for
phosphonate (12) (80 mg, 0.17 mmol) and the corresponding 30 min. Meanwhile a second solution was prepared dissolving LiBr
aldehyde (13 or 14) (0.37 mmol) in dry THF (10 mL) under argon (688 mg, 7.92 mmol) and CuBr (568 mg, 3.96 mmol) under argon
atmosphere was heated to reflux, then potassium tert-butoxide atmosphere in anhydrous THF (50 mL) at 0 C. The first solution
(56 mg, 0.50 mmol) was added. The solution was refluxed for 3 h was slowly added to the second and then the resulting mixture was
and then allowed to cool to room temperature and methanol stirred. After 10 min oxalyl chloride (226 mg, 1.78 mmol) was added
(5 mL) was added. After the solvent was removed the residue was slowly. The mixture was stirred at 0 C for 1 h and then allowed to
purified by column chromatography (CH2Cl2 until elution of warm to room temperature. The solution was then poured into a
unchanged aldehyde and then CH2Cl2 with 2% MeOH). saturated solution of NH4Cl. The organic phase was separated and
HAT-Alkene(OHex)2 (1): A yellow-orange solid was isolated the aqueous phase extracted with two portions of ether. The organic
(64 mg, 60%). 1H NMR (400 MHz, CDCl3) δ (ppm) 9.22 (d, 2H, extracts were dried with MgSO4 and filtered and the solvent was
J = 2.1 Hz), 9.21 (d, 2H, J = 2.1 Hz), 8.23 (d, 2H, J = 15.2 Hz), removed.
7.67 (d, 4H, J = 9.0 Hz), 7.59 (d, 2H, J = 15.2 Hz), 6.95 (d, 4H,
J=9.0 Hz), 4.01 (t, 4H, J=7.3 Hz), 1.90-1.70 (m, 4H), 1.57- (53) Faust, R.; Weber, C.; Fiandanese, V.; Marchese, G.; Punzi, A.
1.2 (m, 12H), 0.92 (t, 6H, J = 7.0 Hz). 13C NMR (100 MHz, Tetrahedron 1997, 53, 14655–14670.