Nội dung seminar của các Giáo sư trường Tokyo Institute of Technology

Nội dung seminar gồm 2 phần:

1. Giới thiệu về nghiên cứu và các hướng nghiên cứu gần đây của 2 GS (như trong abstract
kèm theo bên dưới)
2. Giới thiệu về các chương trình sau đại học tại Tokyo Institute of Technology

Thông tin về các GS và Research Presentation

1. GS. Toshiyuki Ikoma - Dept. of Materials Science and Engineering, Tokyo Institute of
Technology
Main research topics: Biomaterials, Artificial bones, Catalysis for Air Purification.
Research presentation title: “Hydroxyapatite Nanocrystals for Medical Applications”

ABSTRACT
In increasing deaths from cancer, early detection of tumors has been demanded for early
therapy. Fluorescent bioimaging technology for cancer diagnoses has been investigated; this
technology is based on nanoparticles which can emit light by irradiation of an exciting light. The
nanoparticles should be specifically incorporated into tumor cells via endocytosis. This
technology will realize the early detection of tumor tissues before hypertrophy. There are still
issues about nano-toxicology and phototoxicity. Hydroxyapatite (Ca10(PO4)6(OH)2; HAp) is one
of important bio-minerals and composed of hard tissues. HAp with plate-like morphology has
approximately 40 nm in length and 5nm in width in which phosphate groups in the lattice is
substituted by carbonate ions. Thus, the sintered porous body has been applied as artificial bone
materials for the last several decades. These facts strongly indicate that the HAp nanoparticles
show excellent biocompatibility and low cytotoxicity. Luminescent HAp nanocrystals have been
prepared by different methods; for example, lanthanide-doped HAp nanorods have been focused
in cell imaging by precipitation, hydrothermal, or microemulsion method. The europium(III)-
doped HAp (Eu:HAp) nanorods show lower phototoxicity since the wavelength of exciting light
could be higher than 400 nm. To improve the incorporation of nanorods into cells, surface
functionalization should be desired. In this study, Eu:HAp nanorods were synthesized by a
hydrothermal method to decrease the carbonate contents in the HAp lattice, and the surface of
nanorods were functionalized with silane coupling agents and folic acid (FA) to enhance
endocytosis of cancer cells. The Eu:HAp nanorods were synthesized by the hydrothermal
method; the hydrothermal treatment was at 150C for 24 hours in which the molar ratio of Ca
and Eu(III) was fixed at 9 to 1. The surface of nanorods was initially covered with 3-
aminopropultriethoxysilane (APTES) to cover whole surface area of the nanorods. Then, FA was
covalently crosslinked at amino groups of APTES; the molar contents of FA against that of
APTES covered on the nanorods were controlled at 1.0 (FA1), 0.5 (FA0.5), 0.3 (FA0.3), and
(FA0.1). The photoluminescent properties of FA-functionalized nanorods were measured at
397nm of the exciting light, and the incorporation of the nanorods into cancerous cells (HeLA
and A549) were conducted at 1 day incubation. The Eu:HAp nanorods showed a single phase of
HAp from the X-ray diffraction pattern, and had a low carbonate content from the Infrared
spectrum. Fluorescence spectra of the FA-functionalized Eu:HAp nanorods were measured;
although the intensity of the nanorods with ATEPS were not changed, those of the FA-
functionalized Eu:HAp nanorods were apparently decreased with the increase of FA. This was
caused by the absorption of exciting light at 397nm for FA. Functionalization of FA on Eu:HAp
nanorods apparently exhibited larger incorporation number at 4.7 than the Eu:HAp nanorods;
however, less FA amount caused larger incorporation number of the nanorods. These results
suggested that the optimum amount of FA was of great important for photoluminescent property
and caused specific incorporation of Eu:HAp nanorods into cells.

2. GS. Nobuhiro Matsushita - Dept. of Materials Science and Engineering, Tokyo Institute of
Technology
Main research topics: Solution-based processes for functional ceramic materials for
Environmental/Energy, Bio-medical and Electronics applications
Research presentation title: “Solution-processed Ferrite Films and ZnO Films - High
Frequency Applications and Transparent Conductive Oxides –“

ABSTRACT
Spin-spray process enables to deposit the crystallized ferrite films and ZnO films on glass
and polyimide substrate by only spraying source solutions including source metal ions and
reaction solutions including pH adjuster at temperature below 100˚C without post-deposition
heat treatments.
The fabricated ferrite films exhibited both of a high real part of magnetic permeability μ’
up to hundreds MHz and a strong magnetic loss μ” (imaginary part of magnetic permeability) in
GHz ranges. The Zn composition x = 0 - 0.56 of ZnxFe3-xO4 film was controlled by Zn ion
concentrations in reaction solution. Although the film without Zn substitution had low resistivity
in 10-1 Ω･cm order, Zn0.36Fe2.64O4 film had the resistivity in 102 Ω･cm order enough high for the
application in MHz range. The films had large saturation magnetization of 570-600 emu/cm3.
They exhibited relatively high μ’ of 80 and high resonance frequency of 500 MHz. The planar
power inductor, 850 x 850 μm in area and 49 μm in height, was fabricated by sandwiching two-
turn cupper coil using Zn-substituted ferrite layerrs. This planar inductor exhibited high L of 10
nH and Q of 20 at 100 MHz which is enough for the practical application as planar inductor.
Ni0.2Zn0.3Fe2.5O4 films deposited on polyimide sheets (25 μm thick) and their transmission loss
ΔPloss and the reflection coefficient S11 in GHz range were evaluated by pressing the ferrite films
onto 50 ohm microstrip line. The film 5 μm in thickness exhibited transmission loss ΔPloss of 40
%, which was superior to 20 % of commercialized noise suppression sheet 25 μm in thickness.
The reflections coefficient S11 < -10 dB in GHz range was enough small to be used as the
conducted noise suppressors.
Functional transparent conductive oxide (TCO) films have been used for various
applications. Among the TCO materials, zinc oxide (ZnO) is one of superior candidates as
alternative materials for ITO due to their several merits such as low cost of raw material and
wide band gap energy (~ 3.7 eV). We succeed in fabricating transparent zinc oxide (ZnO) film
by spin-spray method, a kind of solution process, at low temperature below 100ºC adding tri-
sodium citrate in the solutions. The films irradiated by UV black light exhibited the low
resistivity below -10-2 Ω･cm due to hydrogen doping.