NAME- NAMDEO DNYANDEO DONGARE

PRN- 1616

CLASS- M.SC-II (STATISTICS)

ST B2 Analysis of Clinical Trials (Assignment - IV)

Question -1)
#TEST FOR EQUALITY
>
> beta=0.20
> theta=0.50
> alpha=0.05
> c=0
> k=100
> ab=0.9
> while(ab<1)
+{
+ ab=abs(qt(alpha/2,k-1))/(sqrt(k)*theta)
+ k=k-1
+ c=c+1
+}
>k
[1] 16
>c
[1] 84
>
> n=k+2
> error=1
> while(error>0.07){
+ d=pnorm(abs(qnorm(alpha/2))-sqrt(n)*theta)
+ error=abs(beta-d)
+ n=n+1
+}
>n
[1] 28
>
>
> while(error>0.07)
+{
+ a=abs(qt(alpha/2,n-1))/(sqrt(n)*theta)
+ b=qt(a,n-1)
+ error=abs(b-beta)
+ n=n+1
+}
>n
[1] 28

Question -2)

TEST FOR NON_INFERIORITY/SUPERIORITY

> beta=0.20
> theta=1
> alpha=0.05
> c=0
> k=100
> ab=0.9
> while(ab<1)
+{
+ ab=abs(qt(alpha/2,k-1))/(sqrt(k)*theta)
+ k=k-1
+ c=c+1
+}
>k
[1] 5
>c
[1] 95
>
> n=k+2
> error=1
> while(error>0.07){
+ d=pnorm(abs(qnorm(alpha/2))-sqrt(n)*theta)
+ error=abs(beta-d)
+ n=n+1
+}
>n
[1] 8
>
>
> while(error>0.07)
+{
+ a=abs(qt(alpha/2,n-1))/(sqrt(n)*theta)
+ b=qt(a,n-1)
+ error=abs(b-beta)
+ n=n+1
+}
>n
[1] 8

Question -3)

TEST FOR EQUIVALENCE

> beta=0.10
> theta=0.50
> alpha=0.05
> c=0
> k=100
> ab=0.9
> while(ab<1)
+{
+ ab=abs(qt(alpha/2,k-1))/(sqrt(k)*theta)
+ k=k-1
+ c=c+1
+}
>k
[1] 16
>c
[1] 84
>
> n=k+2
> error=1
> while(error>0.07){
+ d=pnorm(abs(qnorm(alpha/2))-sqrt(n)*theta)
+ error=abs(beta-d)
+ n=n+1
+}
>n
[1] 35
>
>
> while(error>0.07)
+{
+ a=abs(qt(alpha/2,n-1))/(sqrt(n)*theta)
+ b=qt(a,n-1)
+ error=abs(b-beta)
+ n=n+1
+}
>n
[1] 35
Question -4)

TEST FOR EQUALITY

>
> beta=0.20
> theta=0.50
> alpha=0.025
> c=0
> k=1
> l=100
> ab=0.9
> while(ab<1)
+{
+ ab=abs(qt(alpha/2,l-1))/((sqrt(l)*theta)/(sqrt(1/(1/k))))
+ l=l-1
+ c=c+1
+}
>l
[1] 22
>c
[1] 78
>
> n2=l+2
> error=1
>
> while(error>0.01)
+{
+ a=abs(qt(alpha/2,n2-1))/((sqrt(n2)*theta)/(sqrt(1/(1/k))))
+ b=qt(a,(1+k)*n2-2)
+ error=abs(b-beta)
+ n2=n2+1
+}
> n2
[1] 64

Question -5)

TEST FOR NON_INFERORITY

> beta=0.20
> theta=0.50
> alpha=0.05
> c=0
> k=1
> l=100
> ab=0.9
> while(ab<1)
+{
+ ab=abs(qt(alpha/2,l-1))/((sqrt(l)*theta)/(sqrt(1/(1/k))))
+ l=l-1
+ c=c+1
+}
>l
[1] 16
>c
[1] 84
>
> n2=l+2
> error=1
>
> while(error>0.01)
+{
+ a=abs(qt(alpha/2,n2-1))/((sqrt(n2)*theta)/(sqrt(1/(1/k))))
+ b=qt(a,(1+k)*n2-2)
+ error=abs(b-beta)
+ n2=n2+1
+}
> n2
[1] 49

Question -6)

TEST FOR EQUIVALENCE

> beta=0.10
> theta=0.40
> alpha=0.05
> c=0
> k=1
> l=100
> ab=0.9
> while(ab<1)
+{
+ ab=abs(qt(alpha/2,l-1))/((sqrt(l)*theta)/(sqrt(1/(1/k))))
+ l=l-1
+ c=c+1
+}
>l
[1] 25
>c
[1] 75
>
> n2=l+2
> error=1
>
> while(error>0.07)
+{
+ a=abs(qt(alpha/2,n2-1))/((sqrt(n2)*theta)/(sqrt(1/(1/k))))
+ b=qt(a,(1+k)*n2-2)
+ error=abs(b-(beta/2))
+ n2=n2+1
+}
> n2
[1] 84
>
The folowing things are also required .
1) TWO SAMPLE CROSSOVER DESIGN
2) TEST FOR EQUALITY
> beta=0.10
> theta=1.50
> alpha=0.05
> c=0
> k=1
> l=100
> ab=0.9
> while(ab<1)
+{
+ ab=abs(qt(alpha/2,2*l-2))/((sqrt(l)*theta))
+ l=l-1
+ c=c+1
+}
>l
[1] 2
>c
[1] 98
>
> n2=l+2
> error=1
>
> while(error>0.07)
+{
+ a=abs(qt(alpha/2,2*n2-1))/((sqrt(n2)*theta))
+ b=qt(a,2*n2-2)
+ error=abs(b-beta)
+ n2=n2+1
+}
> n2
[1] 8

Question -7)

TEST FOR NON INFERORITY

> beta=0.20
> theta=1
> alpha=0.05
> c=0
> k=1
> l=100
> ab=0.9
> while(ab<1)
+{
+ ab=abs(qt(alpha/2,2*l-2))/((sqrt(l)*theta))
+ l=l-1
+ c=c+1
+}
>l
[1] 4
>c
[1] 96
>
> n2=l+2
> error=1
>
> while(error>0.07)
+{
+ a=abs(qt(alpha/2,2*n2-1))/((sqrt(n2)*theta))
+ b=qt(a,2*n2-2)
+ error=abs(b-beta)
+ n2=n2+1
+}
> n2
[1] 13