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ABSTRACT

Background: Staphylococcus aureus is one of the main causes of infection that can cause morbidity and mortality.
In the treatment of infectious diseases, resistance is a problem that often arises. This increase in bacterial resistance
to antibiotics provides an opportunity to obtain antibacterial compounds by utilizing bioactive compounds from
biodiversity in Indonesia, one of them is bivalvia. Southeast Sulawesi Province has high biological resources such
as pokea (Batissa violacea celebensis). Pokea clams (Batissa violacea celebensis) contain secondary metabolic
compounds of alkaloids, flavonoids, saponins and steroids which have potential to be antibacterial. This study aims
to analyze pokea clam meat extract (Batissa violacea celebensis) on the growth of Staphylococcus aureus .Research
Purpose: This study aims to analyze pokea clam meat extract (Batissa violacea celebensis) on the growth of
Staphylococcus aureus. Research Methods: This study is a laboratory experimental study with post test only control
design with independent variables, pokea clam meat extract (Batissa violacea celebensis) and the dependent
variable is the inhibition zone on the growth of Staphylococcus aureus. Antibacterial activity testing was carried out
using the pour disk diffusion method with concentrations of 100%, 75%, 50%, 25%, 12.5% and 6.25% with three
repetitions. Cefotaxime was used as a positive control and Aquades as a negative control. Research Result: The
results showed that pokea clam meat extract (Batissa violacea celebensis) with various concentrations could not
inhibit the growth of Staphylococcus aureus. This is known from the absence of clear zones around paper disk.
Conclusion The conclusion of this study is pokea clam meat extract (Batissa violacea celebensis) has no
antibacterial activity against the growth of Staphylococcus aureus and the minimum inhibitory content (MIC) of
pokea clam meat extract (Batissa violacea celebensis) on Staphylococcus aureus growth cannot be determined.
Keywords: Pokea Shellfish (Batissa violacea celebensis), Antibacterial, Staphylococcus aureus.