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DOI: 10.1111/tog.

12228 2015;17:281–7
The Obstetrician & Gynaecologist
Review
http://onlinetog.org

Exercise in pregnancy
a b c,
Katy Kuhrt BSc, Natasha L Hezelgrave MBBS BSc, Andrew H Shennan MD FRCOG *
a
Foundation Year 1 Trainee, Division of Women’s Health, King’s College London, 10th Floor North Wing, St Thomas’ Hospital, Westminster Bridge
Road, London SE1 7EH, UK
b
NIHR Research Fellow, Division of Women’s Health, King’s College London, 10th Floor North Wing, St Thomas’ Hospital, Westminster Bridge Road,
London, SE1 7EH UK
c
Professor of Obstetrics, Division of Women’s Health, King’s College London, 10th Floor North Wing, St Thomas’ Hospital, Westminster Bridge Road,
London, SE1 7EH UK
*Correspondence: Andrew Shennan. Email: Andrew.shennan@kcl.ac.uk

Accepted on 1 June 2015

Key content  To recognise longer term benefits of exercise on maternal and


 The physiology of pregnancy and responses to exercise. fetal health.
 The benefits of exercise in pregnancy.
Ethical issues
 The potential harms related to exercise in pregnancy.
 Consider the variable national recommendations and their impact
 Guidelines and recommendations for exercise in pregnancy.
on pregnant women.
Learning objectives  Acknowledge the lack of specific research on intensity and nature
 To understand the interaction between the physiology of exercise of exercise.
and pregnancy.
Keywords: birthweight / exercise / gestational age / physiology of
 To be able to counsel women regarding the benefits and harms of
pregnancy / pregnancy
exercise in pregnancy.

Please cite this paper as: Kuhrt K, Hezelgrave NL, Shennan AH. Exercise in pregnancy. The Obstetrician & Gynaecologist 2015;17:281–7.

theoretical concerns that exercise, particularly at high


Introduction
intensity, could lead to low birthweight, possibly as a result
More than two thirds of pregnant women take part in some of diminished uteroplacental blood flow and reduced
type of recreational physical activity.1 However, only 15% of substrate availability for the growing fetus.9 Other
pregnant women exercise at a recommended level.2 Whilst hypothetical risks of high intensity exercise are preterm
guidelines exist for minimum recommended weekly exercise delivery,10 abnormal fetal heart rate patterns11–13 and exercise
in uncomplicated pregnancies (30 minutes moderate exercise generated heat stress with teratogenic effects14, although
on most, if not all, days of the week),3 there is a paucity of there is a lack of substantial evidence to prove these effects.
advice for women who want to exercise more intensely, and Pregnancy is a unique window of opportunity to optimise
for those at risk of pregnancy-associated complications such women’s health behaviour. It is therefore important that the
as gestational diabetes mellitus (GDM), pre-eclampsia and risks and benefits of exercise are well understood so that
gestational weight gain (GWG). programs of physical activity can be tailored to individual
Evidence in the literature suggests that exercise may reduce pregnant women. Some pregnant women want to exercise to
GWG4 and GDM,5 both of which are associated with large- maintain fitness levels. However, exercise could act as a
for-gestational-age (LGA) infants,6 birth trauma, neonatal crucial intervention to improve health outcomes for mother
hypoglycaemia and other perinatal complications, as well as and baby in the short and the long term, particularly for
compromised longer term health, as per the fetal origins those at risk of complications.
hypothesis.7 Exposure to GDM and maternal obesity is
thought to program a fetus for adult adiposity, type II
Physiology of pregnancy and responses to
diabetes mellitus and cardiometabolic risk factors. Therefore
exercise in pregnancy
prevention of weight gain and diabetes through exercise
during pregnancy may improve both short- and long-term Cardiovascular adaptations
infant outcomes. However, there is ‘trouble at both ends of Maternal haemodynamics alter during pregnancy to
the birthweight spectrum’ as low birthweight is associated adequately provide nutrients and oxygen to the mother and
with a period of catch-up growth in childhood, and later fetus. Blood volume increases by 40% and stroke volume by
obesity and increased cardiovascular disease risk.8 There are 10%15 by the end of the first trimester. Heart rate and cardiac

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Exercise in pregnancy

output are increased by 20%16 and 30–50%17 respectively peripheral and evaporative cooling through sweating), which is
from the second trimester. There is a corresponding decrease more likely in hot, humid conditions or during very strenuous
in systemic vascular resistance to allow sufficient perfusion of prolonged exercise, the core temperature will continue rising.
the placenta.18,19 Mean arterial pressure decreases by mid-
second trimester by 5–10 mmHg because of the development Musculoskeletal adaptations
of the uteroplacental circulation and reduced vascular Weight gain in pregnancy may considerably increase forces
resistance of the skin and kidney, before returning to across the hip and knee joints during weight bearing exercises
prepregnancy levels.15 like running, potentially resulting in discomfort and even
Sustained bouts of maternal exercise may cause acutely damage in previously unstable joints.
reduced oxygen and nutrient delivery to the placenta as blood The growing uterus causes a shift in the centre of gravity
is diverted to skin and exercising muscles, and as a result of leading to lumbar lordosis and lower back pain in 40–50% of
the relatively poor autoregulation of the placental circulation. pregnant women.25 Balance problems may result from these
The magnitude of the decrease varies with type and intensity anatomical changes, predisposing a woman to injury or even
of exercise, maternal fitness and the stage of pregnancy. falls. Increased estrogen and relaxin levels cause ligamentous
However, in general it is thought that regular exercise, laxity – the pubic symphysis widens 10 mm from 10–12
especially weight-bearing, optimises maternal cardiovascular weeks of gestation – and some women will experience
adaptations and improves placental size and function to symptoms as a result of this.26 There is little evidence to
maintain sufficient oxygen and nutrient supply to the fetus.20 substantiate the risks of musculoskeletal damage during
exercise in pregnancy but, depending on the intensity of
Respiratory adaptations exercise, they may cause issues for some women.
During pregnancy there is a 50% increase in minute
ventilation, mostly due to increased tidal volume21 and
Benefits of exercise in pregnancy
oxygen tension (the partial pressure of oxygen in the blood).
Due to a rise in baseline oxygen consumption of 10–20% and Pre-eclampsia
increased work of breathing secondary to the pressure of the Hypertensive disorders of pregnancy, including gestational
growing fetus on the diaphragm, less oxygen is available hypertension (new onset hypertension during pregnancy
during aerobic exercise. Maximum exercise performance is after 20 weeks of gestation) and pre-eclampsia (gestational
therefore decreased although in some fit women there is no hypertension with proteinuria) are amongst the leading
evidence of reduced aerobic power. causes of maternal mortality worldwide.27 Pre-eclampsia is
associated with increased risk of preterm birth, neonatal
Nutritional requirements intensive care unit admissions and fetal death.28 Given that
Around 300 kcal extra maternal intake is needed by the end the only effective treatment is delivery, a simple intervention
of the first trimester and this increases with greater energy like exercise training for women at risk could have a
expenditure as a result of exercise.22 Pregnant women have substantial impact as a prophylactic and adjunctive
lower fasting blood glucose and use carbohydrates at a greater treatment, if proven to be effective.
rate at rest and during exercise. Physical activity during Case–control studies in the USA have suggested a possible
pregnancy also lowers insulin levels. Pregnancy induces a associated protective effect of physical activity in early
state of relative insulin resistance to increase glucose pregnancy against pre-eclampsia with reduced odds between
availability to the fetus. Decreasing insulin resistance, 30% and 80%.29–31 However, prospective cohort studies and
through exercise, is thought to possibly leave the fetus small randomised controlled trials (RCTs) have largely failed
competing with its mother for glucose.23 to demonstrate significant results after adjusting for
Pregnancy is associated with tissue storage of fat. Conversely confounding factors32 and some studies have even found a
exercise induces substrate mobilisation which could, in theory, deleterious effect. The Danish National Birth Cohort study, of
limit fetal substrate availability,24 particularly if the woman 83 139 women, showed that physical activity for 4–7 hours or
does not regularly maintain adequate complex carbohydrate more than 4 hours a week significantly increased odds of
intake to meet her additional requirements and ensure developing severe subtypes of pre-eclampsia (OR 1.6, 95% CI
adequate supply of nutrients to the growing fetus. 1.1–2.4 and OR 1.8, 95% CI 1.1–3.0, respectively)33 suggesting
that there may be an upper limit beyond which increased
Thermoregulatory control physical activity may be damaging. Despite inconclusive
During pregnancy, heat production is increased secondary to evidence, several mechanisms have been suggested to explain
increased basal metabolic rate. Body temperature increases in potential protective effects of exercise against pre-eclampsia.
relation to the intensity of exercise. If heat production exceeds A double-blinded RCT of 64 primigravid women between 16
heat dissipation capacity (increased conductance of heat to the and 20 weeks of gestation, where women were randomised to

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Kuhrt et al.

either 60 minute sessions of moderate exercise three times Observational evidence suggests that physical activity
weekly or ‘usual physical activity’, showed significantly greater during pregnancy can play a significant role in preventing or
flow-mediated endothelial dilatation in the exercise group.34 reducing excessive GWG. Mild walking programs are
Since endothelial dysfunction is linked to pre-eclampsia, associated with reduced excessive GWG.42 Beneficial effects
improving flow mediated dilation might reduce the risk of may extend into the long term; Rooney et al.43 showed that
developing the disorder. women who began and continued aerobic exercise postpartum
Other possible mechanisms are promotion of placental had gained 4.5 kg on average at 10-year follow-up compared
growth by the short-lived hypoxic environment during with 6.7 kg for women who didn’t exercise; these women were
exercise as blood is diverted to skin and muscle,20 also significantly less likely to have become obese
combating oxidative stress induced by free radicals A 2011 systematic review and meta-analysis of 12 RCTs
generated by remodelling of uterine and placental arteries designed to reduce GWG also showed positive associations; a
in pre-eclampsia,35 and improving deranged immune significant reduction in GWG of –0.61 (95% CI –1.17, –0.06)
function through reducing pro-inflammatory mediators was demonstrated when comparing physical activity with a
and increasing anti-inflammatory cytokines. control group.41 However, sample sizes were small in the
More work is needed to determine effects of exercise on included studies and definitions of GWG varied.
the pathophysiology and clinical presentation of pre- In general, robust evidence is scarce and further
eclampsia. Larger randomised trials of varying intensity of investigation is needed to quantify the amount of exercise
physical activity initiated at different pregnancy gestations that is beneficial to women of different body mass indices and
would provide firmer evidence on the true effect of physical which types of physical activity are most effective to
activity on pre-eclampsia risk. Beyond exercise limiting reduce GWG.
weight gain prepregnancy, it cannot be recommended as a
preventative strategy for pre-eclampsia. Gestational diabetes mellitus
GDM is glucose intolerance or hyperglycaemia with onset or
Gestational weight gain first diagnosis during pregnancy. It affects 1–4% of
Overweight women who gain more than 10% of their pregnancies, depending partly on the variable definitions
prepregnancy mass are at a higher risk of complications such worldwide, and is associated with short- and long-term risks
as GDM, hypertensive disorders of pregnancy, caesarean for mother and baby.39
section and medically indicated preterm delivery.36,37 Women with GDM have higher rates of labour induction,
Women who gain excessive weight during pregnancy are caesarean section, and pre-eclampsia. Uterine rupture and
more likely to give birth to LGA (OR 1.38, 95% CI 1.32–1.44) perineal lacerations are commoner because GDM women are
and macrosomic babies (OR 1.43, 95% CI 1.24–1.64), at more likely to have an LGA or macrosomic (>4000 g) baby.
increased risk of neonatal hypoglycaemia, perinatal trauma Babies born to mothers with GDM are more likely to suffer
and death, and obesity, diabetes and metabolic syndromes in perinatal trauma, including shoulder dystocia and nerve
later life.38,39 A recent cohort study of 4145 mother/child palsies, because of their large size, and other neonatal
pairs showed that children of mothers who had gained weight complications such as respiratory distress syndrome
in excess of current Institute of Medicine recommendations and hypoglycaemia.39
had a 46% increased odds of being obese or overweight at In the long term, women with GDM are 7–8 times more
2–5 years of age (OR 1.46; 95% CI 1.17–1.83). The effect of likely to develop type II diabetes in later life. Treatment in
GWG was increased for offspring of women who were pregnancy has not been shown to modify this risk as it may
normal weight before pregnancy compared with those who just unmask an underlying potential for insulin resistance.
were overweight. This suggests that the effect is independent There are also long-term risks for the infant; exposure to
of genetic predictors of obesity40 and, instead, is potentially diabetes in utero is associated with a higher prevalence of
related to GWG and subsequent changes in maternal insulin diabetes in infants, impaired glucose tolerance in adolescence
resistance, which permanently alter fetal systems for and with an excess of obesity especially in the first 20 years of
programming body weight. The effects should therefore life. Potential mechanisms include long-term changes in fat
continue into adolescence and early adulthood and this has and lean body mass, altered appetite regulation and deranged
been shown.41 Maternal GWG is also directly associated with pancreatic structure and function.8
postpartum weight retention. Thus, GWG is detrimental to Recent observational studies have found physical activity
the mother and infant and leads to a vicious cycle of excessive during pregnancy reduces insulin resistance and so might
GWG and adiposity, which is passed to the offspring and to help lower risk of GDM. Mild walking programs, compared
their offspring in turn. An intervention to reduce GWG could with standard care, achieved lower glucose concentrations
break this cycle and positively impact the health of current and required fewer units of insulin per day (walking,
and future generations. 0.16U/kg; standard care, 0.50U/ kg; P<0.05).5

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Exercise in pregnancy

Evidence from a recent meta-analysis showed that women activity, respectively. Further work is needed to clarify
who exercised before and during pregnancy reduced their these relationships.
risk of GDM by 55% and 24% respectively (pooled OR 0.76,
95% CI 0.70–0.83; P<0.001).44 However, the confidence Low birthweight
intervals were wide and the authors compared only the Smaller babies have increased rates of perinatal
highest category of exercise to the lowest. In the highest complications, including hypoglycaemia, hypothermia,
category women commonly exercised more intensely than necrotic enterocolitis, chronic lung disease and death. They
current recommendations suggest, so further work is needed also have increased rates of long-term metabolic sequelae and
to establish the minimum dose of physical activity required of later adult diseases, including coronary heart disease and
to have a beneficial effect. type II diabetes mellitus.48
A 2012 Cochrane review examined five intervention trials A 2009 review of GWG and child adiposity highlighted the
of 115 women and their babies and found no difference in possibility of a U-shaped association between maternal
GDM incidence between women either receiving routine care weight and child adiposity with greater overweight risks at
or exercising. No long-term outcomes were reported from low and high GWG. One study showed a significantly greater
any of the studies, which were small and varied widely in obesity risk in 18-year-old daughters born to mothers
their interventions and methodologies.39 who gained less than 10 lb compared with those who
Overall larger randomised trials with standardised gained 15–19 lb (OR 1.54; 95% CI 1.02–2.34).49 It is thought
interventions and long-term outcomes are needed to derive that this effect is due to the development of a ‘survival
sufficient evidence to guide practice. phenotype’ where infants with poor in utero nutrition
experience catch-up growth; this is beneficial in early life
but contributes to worse health outcomes in the long term.
Potential harms related to exercise in
Exercise in pregnancy causes a temporary reduction in
pregnancy
oxygen and nutrient delivery to the placenta as blood is
Preterm delivery redirected to working muscles. Maternal blood volume,
A 2006 Cochrane review of 11 trials, including 472 women, cardiac output and placental function have been found to
found insufficient data to determine the effects of exercise on increase in exercising women but it is uncertain whether
preterm delivery.32 Studies focusing on physical exercise these mechanisms provide adequate oxygen and nutrient
found either decreased or no extra risk of preterm birth (not supply to the fetus.47
specified whether spontaneous or iatrogenic).44–46 Other Clapp and colleagues50,51 conducted a series of
studies have shown a 20–50% reduction in preterm birth in prospective studies attempting to establish the effects of
exercising women compared with those who didn’t exercise exercise on birthweight and found that women exercising
during pregnancy.47 A 2012 prospective observational study in pregnancy delivered healthy (including in the long term)
looked specifically at the effects of vigorous physical activity babies weighing 310 g lighter; this was entirely attributed
and found reduced odds of preterm birth.23 Jukic et al.23 to decreased fat mass. Conversely, previously sedentary
suggested a proposed mechanism to explain their analysis women who began exercise in pregnancy gave birth to
where the frequency of vigorous activity sessions was babies who were 260 g heavier and both fat mass and lean
associated with a lower risk of preterm birth. Regular body mass was increased. They also showed that
exercise may result in improved placental function overall; birthweight was affected depending on the pattern of
a physical activity session could be associated with a decrease exercise in pregnancy; women exercising early and stopping
in nutrient delivery to the placenta, followed by an increase as late in pregnancy had heavier babies compared
the woman recovers. The more frequent the exercise sessions, with women exercising moderately throughout pregnancy
the more fluctuation there will be in nutrient delivery to the (460g; P<0.001).50 Women who exercised most in late
placenta. This could stimulate placental growth. However pregnancy had the lightest babies. This variation was
this particular study only investigated the effects of exercise attributed to changes in placental function throughout
in the first trimester. Further investigation is needed to pregnancy and needs further exploration to establish
establish whether there is a minimum threshold for the optimal exercise programs at different points in
protective effect that has been observed and if the protective pregnancy for different groups of women. They also
effect of exercise against preterm birth remains if the woman showed that the smaller babies of exercising mothers
continues to exercise vigorously later in her pregnancy. were not disadvantaged in early life. They remained lighter
Details regarding whether the early birth is iatrogenic or and leaner than controls (18 kg versus 19.5 kg; P = 0.01;
spontaneous are often lacking in the literature, and sum of 5 skinfolds: 37 versus 44 P<0.01) and performed
mechanisms would be very different, that is, mediated better overall in intelligence tests (115 versus 111; P<0.01)
through placental disease or cervical pressure/uterine at 5 years of age.51

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Conversely, a more recent population based observational CI 1.61–2.29)14 but there is no evidence that exercise can
study of 79 692 pregnancies showed that exercising mothers induce this level of heat stress.
had a decreased risk of SGA (hazard ratio 0.87; 95% CI
0.83–0.92) and LGA (hazard ratio 0.93; 95% CI 0.89–0.98)
Guidelines and recommendations
babies. The effect on LGA increased with more regular
exercise; five times weekly exercise was associated with a There are few specific recommendations for exercising in
27% reduction in risk (hazard ratio = 0.72; 95% CI pregnancy as robust RCTs are difficult to perform and are
0.57–0.91). The Norwegian Mother and Child Cohort lacking. Likewise observational studies are often not
Study found a similar effect where risk of LGA was sufficiently powered to derive firm conclusions about the
reduced by 23% with regular exercise (OR 0.77; 95% CI
0.61–0.96).47,52 Proposed mechanisms to explain these Table 1. A comparison of the American College of Obstetricians and
potential benefits include normalisation of maternal blood Gynecologists (ACOG)3 and National Institute for Health and Care
Excellence (NICE)56 recommendations for exercise during pregnancy.
glucose, reduced maternal insulin resistance and increased
placental surface area and volume which improves its ACOG guidelines NICE guidelines
functional capacity and nutrient delivery.20,53
More work is needed to systematically explore the effects Duration and  30 minutes or more of  At least 30 minutes of
of exercise in different women at various stages of pregnancy, intensity moderate intensity moderate exercise
exercise on most, if not per day.
including different types of exercise. Trials should be large all, days of the week,  Women who exercised
with consistent methodologies and outcomes so that their provided no medical/ regularly before
findings can be more easily compared before confident obstetric complications. pregnancy should be
 Recreational and able to continue with
recommendations can be made.
competitive athletes no adverse effects.
can remain active  Women who haven’t
Fetal Distress during pregnancy and exercised routinely
Fetal bradycardic episodes have been associated with fetal should modify their should begin with 15
exercise routines as minutes of continuous
hypoxia. Studies using Doppler monitors to estimate fetal
medically indicated. exercise three times
heart rate have previously reported prolonged fetal  Women should be weekly, increasing to
bradycardia during low-intensity maternal exercise.22 evaluated before daily 30-minute
Speculative mechanisms include a vagal reflex, cord recommendations for sessions.
physical activity are
compression or fetal head compression possibly related to made if previously
malposition.22 However, a 1988 study measuring fetal heart inactive or medical/
rate in 45 pregnant women in response to repetitive obstetric complications.
submaximal and maximal cycle tests concluded that brief Type of  Most physical activity  Most recreational
exercise bouts up to 70% of maximal aerobic power, where exercise is safe. exercise including
maternal heart rate was less than 148 beats per minute, had  Ice-hockey, soccer, swimming or brisk
basketball or walking and strength
no effect on fetal heart rate.54 A more recent investigation
gymnastics, horse conditioning exercise is
showed that fetal bradycardia occurred when women riding and downhill safe and beneficial.
exercised more than 90% of maximal maternal heart rate skiing, where the risk of  Sports that may cause
and the mean uterine artery blood flow was less than 50% of impact or falling is abdominal trauma, falls
higher, should or excessive joint stress,
the initial value.55 However, there were only six study be avoided. and scuba diving,
participants and all were Olympic level athletes. The study  Scuba diving should should be avoided.
did not examine birth outcomes due to the small sample size be avoided.
and so it is difficult to ascertain whether there were adverse Postpartum  Prepregnancy exercise  Mild exercise
consequences to the fetus as a result of the bradycardic exercise regimens can be programmes with
episodes.55 Taken together it seems that submaximal exercise resumed gradually as walking, pelvic floor
soon as physically and exercises and stretching
does not adversely affect fetal heart rate and more work is
medically safe, which can begin immediately
needed to establish the effect of more vigorous exercise on a will vary from one  High impact exercise
wider group of women. individual to another. should not begin
too soon.
 A clinician should
Heat stress and teratogenicity advise at 6–8 weeks in
Another potential fetal risk of exercise in pregnancy is the case of more
exercise-generated heat stress. A systematic review of 15 complicated deliveries.
studies found maternal hyperthermia in the first trimester
increased overall risk of neural tube defects (OR 1.92;

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Exercise in pregnancy

prescribing exercise during pregnancy could form part of a


Table 2. Absolute and relative contraindications to aerobic exercise in
pregnancy according to the American College of Obstetricians and valuable intervention to benefit many women and their
Gynecologists (ACOG)3 offspring, and improve the health of future generations. In the
Relative contraindications Absolute contraindications to
meantime, moderate or accustomed exercise in pregnancy
to aerobic exercise aerobic exercise should be encouraged.

 Severe anaemia  Haemodynamically significant Contribution to authorship


 Unevaluated maternal heart disease Professor Shennan conceived the idea, wrote the outline,
cardiac arrhythmia  Incompetent cervix/cerclage supervised the writing and edited and approved the final
 Chronic bronchitis  Multiple gestation at risk of
version. KK was principal author, and researched the
 Poorly controlled type 1 preterm labour
diabetes mellitus  Persistent 2nd/3rd findings. NH advised on the outline, and edited and
 Extreme morbid obesity trimester bleeding approved the final version.
 Extremely underweight  Placenta praevia after 26 weeks
(BMI <12) of gestation Disclosure of interests
 Extremely  Premature labour during
sedentary lifestyle current pregnancy Professor Shennan and Dr Hezelgrave are foundation
 Intrauterine growth  Pregnancy members of the parkrun research board, and have no
restriction in induced hypertension pecuniary or other conflicts of interest relevant to this topic.
current pregnancy

Supporting Information
Additional supporting information may be found in the
effect of maternal exercise on important fetal and maternal
online version of this article at http://wileyonlinelibrary.com/
outcomes. The existing generic guidelines can provide useful
journal/tog
baseline information but care must be taken to tailor advice
appropriately to individual pregnant women. Current Infographic S1. Exercise in pregnancy.
recommendations are summarised in Table 1.3
Generally guidelines encourage exercise in pregnancy. The
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