ADVANCED RESEARCH METHOD 1 LABORATORY

EXERCISE 4
August 30, 2018

Instruction: You can work in groups of 3. Submit your answers in 8.5”x13” .doc/x format at
april.mergelle.lapuz@adamson.edu.ph on or before 5:00PM today.
Perform the appropriate statistical analysis for the studies below using the steps in hypothesis
testing:
a. State the null and alternative hypothesis (2 points)
b. Level of significance (1 point)
c. Test statistics (1 point)
d. Critical Region (2 points)
e. Stata Output for Variable Selection (6 points)
f. Statistical Decision (4 points)
g. Conclusion (6 points)
h. Linear regression model and interpretation (if applicable) (8 points)

1. The purpose of a study by Krantz et al. was to investigate dose-related effects of methadone
in subjects with torsades de pointes, a polymorphic ventricular tachycardia. In the study of
17 subjects, 10 were men (sex = 0) and seven were women (sex = 1). The outcome variable, is
the QTc interval, a measure of arrhythmia risk. The other independent variable, in addition to sex,
was methadone dose (mg/day). Measurements on these variables for the 17 subjects were as
follows. Perform backward selection with the data and report your final model, p-values, and
conclusions.
Sex Dose (mg/day) QTc (msec)
0 1000 600
0 550 625
0 97 560
1 90 585
1 85 590
1 126 500
0 300 700
0 110 570
1 65 540
1 650 785
1 600 765
1 660 611
1 270 600
1 680 625
0 540 650
0 600 625
1 330 522
Source: Data provided courtesy of Mori J. Krantz, M.D.

2. Use lmbd.dta. Perform forward selection with the data and report your final model, p-values, and
conclusions.
3. One purpose of a study by Connor et al. (A-8) was to examine reactive aggression among
children and adolescents referred to a residential treatment center. The researchers used the
Proactive/Reactive Rating Scale, obtained by presenting three statements to clinicians who
examined the subjects. The respondents answered, using a scale from 1 to 5, with 5 indicating
that the statement almost always applied to the child. An example of a reactive aggression
statement is, “When this child has been teased or threatened, he or she gets angry easily and
strikes back.” The reactive score was the average response to three statements of this type. With
this variable as the outcome variable, researchers also examined the following: AGE (years),
VERBALIQ (verbal IQ), STIM (stimulant use), AGEABUSE (age when first abused), CTQ
(a measure of hyperactivity in which higher scores indicate higher hyperactivity), TOTALHOS
(total hostility as measured by an evaluator, with higher numbers indicating higher hostility).
Perform forward selection regression to find the variables most useful in predicting reactive
aggression in the following sample of 68 subjects.
Use reactive.dta.