COLLEGE OF PHARMACY

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ADVANCED RESEARCH METHODS I LABORATORY

Finals Activity 1
November 22, 2018

General Instructions: You can work in groups of 3 or 4. Submit your answers in the following format:
 Short bond paper (8.5” x 13”)
 Font: Calibri size 11; STATA Output Lucida Console 9
Submit your answers with the file name SURNAMEOFMEMBERS.doc/x at
april.mergelle.lapuz@adamson.edu.ph on or before 5:00 PM.

1. Perform hypothesis testing for the studies below using the following format:
a. State the null and alternative hypothesis
b. Level of significance
c. Test statistics
d. Critical Region/Decision Rule
e. STATA output
f. Statistical Decision
g. Conclusion
1. Nozawa et al. (A-10) calculated the Japanese Orthopaedic Association score for measuring back
pain (JOA). The results for the 20 subjects along with the duration of follow-up are shown in the
following table. The higher the number, the lesser the degree of pain.

Can we conclude from these data that in general there is a relationship between length of follow-
up and JOA score at the time of the operation?
2. Ten subjects with exercise-induced asthma participated in an experiment to compare the
protective effect of a drug administered in four dose levels. Saline was used as a control. The
variable of interest was change in FEV1 after administration of the drug or saline. The results were
as follows:
3. A study of young children by Flexer et al. (A-9) published in the Hearing Journal examines the
effectiveness of an FM sound field when teaching phonics to children. In the study, children in a
classroom with no phonological or phonemic awareness training (control) were compared to a
class with phonological and phonemic awareness (PPA) and to a class that utilized phonological
and phonemic awareness training and the FM sound field (PPA/FM). A total of 53 students from
three separate preschool classrooms participated in this study. Students were given a measure of
phonemic awareness in preschool and then at the end of the first semester of kindergarten. The
improvement scores are listed in the following table as measured by the Yopp–Singer Test of
Phonemic Segmentation. Test for significance of the three groups.

4. The purpose of a study by researchers at the Cleveland (Ohio) Clinic (A-6) was to determine if the
use of Flomax® reduced the urinary side effects commonly experienced by patients following
brachytherapy (permanent radioactive seed implant) treatment for prostate cancer. The
following table shows the American Urological Association (AUA) symptom index scores for two
groups of subjects after 8 weeks of treatment. The higher the AUA index, the more severe the
urinary obstruction and irritation. May we conclude, on the basis of these data, that the median
AUA index in the Flomax® group differs significantly from the median AUA index of the placebo
group?