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UKK: Respiratory
Category: ePoster Presentation
Code: P - RES - 031

Clinical characteristic of latent tuberculosis infection

Rizky Arisanti Maharani(1) , Retno Asih Setyoningrum(1)

Department of Child Health, Faculty of Medicine Universitas Airlangga/Dr. Soetomo General Hospital
Surabaya, Indonesia(1)

Background: According to the report of World Health Organization (WHO), there are about 8.6 million
incident cases of tuberculosis (TB) and about 1.3 million deaths from TB annually. Close contacts of active
TB patients are at high risk of both active and latent tuberculosis infection (LTBI). In 2010, the WHO
estimates that nearly 1/3 of the world's population contracted LTBI, and that 10% of these carriers will
develop an active TB infection. The diagnosis and treatment of LTBI have become mandatory to reduce the
burden of TB worldwide.

Objective: To describe the characteristic of Latent Tuberculosis Infection cases.

Method: A retrospective study was performed during January 2006 until December 2015. The definition of
LTBI was classified as TB class 2, a state of persistent immune response to stimulation by Mycobacterium
tuberculosis antigens without evidence of clinically manifested active TB. This group was established as
having close contact active TB and showed positive tuberculin skin test (TST) Data was collected from
medical record of outpatients at respirology clinic at Dr. Soetomo General Hospital.

Result: There were a total of 103 LTBI cases reviewed, which predominantly male (52.4%) and majority
were children under 2 years old (47.6%) with the mean age 18 months (SD 35.43, range 4-180 months).
There were 38 (36.9%) patients who had contact with positive sputum acid fast bacilli (AFB). There were no
LTBI patients who had progression to active TB. It was found that 88 patients completed prophylaxis for
LTBI and 15 patients discontinued medications. In the early of admission, majority cases were referred
from another pediatric clinic at Dr. Soetomo General Hospital (78.6%), community health centre (10.4%),
another hospital (10%) and pediatrician (1%).

Conclusion: Children under 2 years old with close contact of positive AFB are tend to develop LTBI, with no
evidence of progression to active TB.

Keyword : tuberculosis, latent, infection, contact, TST