Professional Documents
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Isma’eel
Mohammad
7/11/2010Matalqa
Abu
Lec#3
1525
Taleb
بسم الله الرحمن الرحيم
Patho lec #15
As you can see there are two sorts of repair as we said previously
it can be either repaired by regeneration ; which means
replacing the injured tissue by the same type of the original
tissue cells , and also you remember that we have dividing cells
like the labile cells and the stable cells which have the ability
( the doctor was interrupted by some 1 who asked about the
exam the doctor said that he will discuss the exam @ the end of
the lecture ) , so we have the labile and stable cells which both
have the capability to regenerate some of them are continuously
dividing during the cycle, some of them upon activation they can
get back to the cycle and regenerate themselves , so in order to
have proper regeneration we have to have two tissue
components :
{slide #1}
Proliferation of fibroblasts
{slide #2}
{slide #3}
{slide #4}
{slide #5}
{Slide #6}
{Slide #7}
{slide #8}
and this is a summary of the degradation of the basement
membrane and then migration , proliferation , organization and
formation of these small blood vessels , and after such
maturation there will be increased permeability through the gabs
and transcytosis which also will facilitate reaching the blood ,
blood components and blood cells to the outside area .
{slide #9}
{slide #10}
interstitial collagenases
gelatinases
stromelysins
{slide #11}
{slide #12}
{slide #13+14}
{slide #15}
{slide #16}
{slide #17}
And that here will summarize the factors which affect healing , as
you can see here there are systemic and local factors.
Corticosteroid treatment
type of tissue ; there are some tissue types which are known
to have weak capability of regeneration than the others
_ excessive movement
_ hematoma
_ in appropriate apposition
{slide #18}
{slide #21}
So in summary what are the repair out come after injury, if you
have any injury in the proper context and proper sittings we have
cellular and vascular response. This just summarizes the whole
process , and if the stimulus is removed in acute injury we can
have parenchyma cell death where intact tissue framework and
this will lead to superficial wounds and some inflammatory
response and this will lead to regeneration . if there is damage to
the (ECM) or framework and the wound were deep this will lead to
healing by scar formation or organization of exudates, and these
are some examples for this (referring to the slide), and if there
were a persistent tissue damage this will be repaired and healed
by fibrosis and tissue scar, and examples for that are like chronic
inflammatory diseases like cirrhosis, chronic pancreatitis and
pulmonary fibrosis.
Good luck :D