Professional Documents
Culture Documents
Blood type
From Wikipedia, the free encyclopedia
Contents
1 Blood group systems
1.1 ABO blood group system
1.2 Rh blood group system
1.3 ABO and Rh distribution by country
1.4 Other blood group systems
2 Clinical significance
2.1 Blood transfusion
2.2 Hemolytic disease of the newborn (HDN)
2.3 Blood products
2.4 Red blood cell compatibility
2.5 Plasma compatibility
2.6 Universal donors and universal recipients
3 Blood group genotyping
4 Conversion
5 History
6 Cultural beliefs and other claims
7 References
8 Further reading
9 External links
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A complete blood type would describe a full set of 30 substances on the surface of RBCs, and an individual's blood
type is one of the many possible combinations of blood-group antigens.[2] Across the 30 blood groups, over 600
different blood-group antigens have been found,[4] but many of these are very rare or are mainly found in certain ethnic
groups.
Almost always, an individual has the same blood group for life, but very rarely an individual's blood type changes
through addition or suppression of an antigen in infection, malignancy, or autoimmune disease.[5][6][7][8] An example of
this rare phenomenon is the case of Demi-Lee Brennan, an Australian citizen, whose blood group changed after a liver
transplant.[9][10] Another more common cause in blood-type change is a bone marrow transplant. Bone-marrow
transplants are performed for many leukemias and lymphomas, among other diseases. If a person receives bone marrow
from someone who is a different ABO type (e.g., a type A patient receives a type O bone marrow), the patient's blood
type will eventually convert to the donor's type.
Some blood types are associated with inheritance of other diseases; for example, the Kell antigen is sometimes
associated with McLeod syndrome.[11] Certain blood types may affect susceptibility to infections, an example being the
resistance to specific malaria species seen in individuals lacking the Duffy antigen.[12] The Duffy antigen, presumably as a
result of natural selection, is less common in ethnic groups from areas with a high incidence of malaria.[13]
Phenotype Genotype
A AA or AO
B BB or BO
ABO blood group system: diagram showing the
AB AB carbohydrate chains that determine the ABO blood group
O OO
The Rh system is the second most significant blood-group system in human-blood transfusion with currently 50 antigens.
The most significant Rh antigen is the D antigen because it is the most likely to provoke an immune system response of
the five main Rh antigens. It is common for D-negative individuals not to have any anti-D IgG or IgM antibodies,
because anti-D antibodies are not usually produced by sensitization against environmental substances. However, D-
negative individuals can produce IgG anti-D antibodies following a sensitizing event: possibly a fetomaternal transfusion
of blood from a fetus in pregnancy or occasionally a blood transfusion with D positive RBCs.[15] Rh disease can
develop in these cases.[16] Rh negative blood types are much less in proportion of Asian populations (0.3%) than they
are in White (15%).[17] In the table below, the presence or absence of the Rh antigens is signified by the + or - sign, so
that for example A- group does not have any of the Rh antigens.
Racial and ethnic distribution of ABO (without Rh) blood types [47]
(This table has more entries than the table above but does not distinguish between Rh types.)
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Aborigines 61 39 0 0
Abyssinians 43 27 25 5
Ainu (Japan) 17 32 32 18
Albanians 38 43 13 6
Grand Andamanese 9 60 23 9
Arabs 34 31 29 6
Armenians 31 50 13 6
Asian (in USA—general) 40 28 27 5
Austrians 36 44 13 6
Bantus 46 30 19 5
Basques 51 44 4 1
Belgians 47 42 8 3
Blackfoot (N. Am. Indian) 17 82 0 1
Bororo (Brazil) 100 0 0 0
Brazilians 47 41 9 3
Bulgarians 32 44 15 8
Burmese 36 24 33 7
Buryats (Siberia) 33 21 38 8
Bushmen 56 34 9 2
Chinese-Canton 46 23 25 6
Chinese-Peking 29 27 32 13
Chuvash 30 29 33 7
Czechs 30 44 18 9
Danes 41 44 11 4
Dutch 45 43 9 3
Egyptians 33 36 24 8
English 47 42 9 3
Eskimos (Alaska) 38 44 13 5
Eskimos (Greenland) 54 36 23 8
Estonians 34 36 23 8
Fijians 44 34 17 6
Finns 34 41 18 7
French 43 47 7 3
Georgians 46 37 12 4
Germans 41 43 11 5
Greeks 40 42 14 5
Gypsies (Hungary) 29 27 35 10
Hawaiians 37 61 2 1
Hindus (Bombay) 32 29 28 11
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Hungarians 36 43 16 5
Icelanders 56 32 10 3
Indians (India—general) 37 22 33 7
Indians (USA—general) 79 16 4 1
Irish 52 35 10 3
Italians (Milan) 46 41 11 3
Japanese 30 38 22 10
Jews (Germany) 42 41 12 5
Jews (Poland) 33 41 18 8
Kalmuks 26 23 41 11
Kikuyu (Kenya) 60 19 20 1
Koreans 28 32 31 10
Lapps 29 63 4 4
Latvians 32 37 24 7
Lithuanians 40 34 20 6
Malaysians 62 18 20 0
Maori 46 54 1 0
Mayas 98 1 1 1
Moros 64 16 20 0
Navajo (N. Am. Indian) 73 27 0 0
Nicobarese (Nicobars) 74 9 15 1
Norwegians 39 50 8 4
Papuas (New Guinea) 41 27 23 9
Persians 38 33 22 7
Peru (Indians) 100 0 0 0
Filipinos 45 22 27 6
Poles 33 39 20 9
Portuguese 35 53 8 4
Romanians 34 41 19 6
Russians 33 36 23 8
Sardinians 50 26 19 5
Scots 51 34 12 3
Serbians 38 42 16 5
Shompen (Nicobars) 100 0 0 0
Slovaks 42 37 16 5
South Africans 45 40 11 4
Spanish 38 47 10 5
Sudanese 62 16 21 0
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Swedes 38 47 10 5
Swiss 40 50 7 3
Tartars 28 30 29 13
Thais 37 22 33 8
Turks 43 34 18 6
Ukrainians 37 40 18 6
USA (US blacks) 49 27 20 4
USA (US whites) 45 40 11 4
Vietnamese 42 22 30 5
Blood group B has its highest frequency in Northern India and neighboring Central Asia, and its incidence diminishes
both towards the west and the east, falling to single digit percentages in Spain.[48][49] It is believed to have been entirely
absent from Native American and Australian Aboriginal populations prior to the arrival of Europeans in those
areas.[49][50]
Blood group A is associated with high frequencies in Europe, especially in Scandinavia and Central Europe, although its
highest frequencies occur in some Australian Aborigine populations and the Blackfoot Indians of Montana.[51][52]
The International Society of Blood Transfusion currently recognizes 30 blood-group systems (including the ABO and
Rh systems).[2] Thus, in addition to the ABO antigens and Rh antigens, many other antigens are expressed on the RBC
surface membrane. For example, an individual can be AB, D positive, and at the same time M and N positive (MNS
system), K positive (Kell system), Lea or Leb negative (Lewis system), and so on, being positive or negative for each
blood group system antigen. Many of the blood group systems were named after the patients in whom the
corresponding antibodies were initially encountered.
Clinical significance
Blood transfusion
Transfusion medicine is a specialized branch of hematology that is concerned with the study of blood groups, along with
the work of a blood bank to provide a transfusion service for blood and other blood products. Across the world, blood
products must be prescribed by a medical doctor (licensed physician or surgeon) in a similar way as medicines.
Much of the routine work of a blood bank involves testing blood from both donors and recipients to ensure that every
individual recipient is given blood that is compatible and is as safe as possible. If a unit of incompatible blood is
transfused between a donor and recipient, a severe acute hemolytic reaction with hemolysis (RBC destruction), renal
failure and shock is likely to occur, and death is a possibility. Antibodies can be highly active and can attack RBCs and
bind components of the complement system to cause massive hemolysis of the transfused blood.
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Patients should ideally receive their own blood or type-specific blood products to minimize the chance of a transfusion
reaction. Risks can be further reduced by cross-matching blood, but this may
be skipped when blood is required for an emergency. Cross-matching
involves mixing a sample of the recipient's serum with a sample of the donor's
red blood cells and checking if the mixture agglutinates, or forms clumps. If
agglutination is not obvious by direct vision, blood bank technicians usually
check for agglutination with a microscope. If agglutination occurs, that
particular donor's blood cannot be transfused to that particular recipient. In a
blood bank it is vital that all blood specimens are correctly identified, so
labeling has been standardized using a barcode system known as ISBT 128.
A pregnant woman can make IgG blood group antibodies if her fetus has a blood group antigen that she does not have.
This can happen if some of the fetus' blood cells pass into the mother's blood circulation (e.g. a small fetomaternal
hemorrhage at the time of childbirth or obstetric intervention), or sometimes after a therapeutic blood transfusion. This
can cause Rh disease or other forms of hemolytic disease of the newborn (HDN) in the current pregnancy and/or
subsequent pregnancies. If a pregnant woman is known to have anti-D antibodies, the Rh blood type of a fetus can be
tested by analysis of fetal DNA in maternal plasma to assess the risk to the fetus of Rh disease.[57] One of the major
advances of twentieth century medicine was to prevent this disease by stopping the formation of Anti-D antibodies by D
negative mothers with an injectable medication called Rho(D) immune globulin.[58][59] Antibodies associated with some
blood groups can cause severe HDN, others can only cause mild HDN and others are not known to cause HDN.[3]
Blood products
To provide maximum benefit from each blood donation and to extend shelf-life, blood banks fractionate some whole
blood into several products. The most common of these products are packed RBCs, plasma, platelets, cryoprecipitate,
and fresh frozen plasma (FFP). FFP is quick-frozen to retain the labile clotting factors V and VIII, which are usually
administered to patients who have a potentially fatal clotting problem caused by a condition such as advanced liver
disease, overdose of anticoagulant, or disseminated intravascular coagulation (DIC)
Units of packed red cells are made by removing as much of the plasma as possible from whole blood units.
Clotting factors synthesized by modern recombinant methods are now in routine clinical use for hemophilia, as the risks
of infection transmission that occur with pooled blood products are avoided.
Blood group AB individuals have both A and B antigens on the surface of their RBCs, and their blood serum
does not contain any antibodies against either A or B antigen. Therefore, an individual with type AB blood can
receive blood from any group (with AB being preferable), but can donate blood only to another type AB
individual.
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Blood group A individuals have the A antigen on the surface of their RBCs, and blood serum containing IgM
antibodies against the B antigen. Therefore, a group A individual can receive blood only from individuals of
groups A or O (with A being preferable), and can donate blood to individuals with type A or AB.
Blood group B individuals have the B antigen on the surface of their RBCs, and blood serum containing IgM
antibodies against the A antigen. Therefore, a group B individual can receive blood only from individuals of
groups B or O (with B being preferable), and can donate blood to individuals with type B or AB.
Blood group O (or blood group zero in some countries) individuals do not have either A or B antigens on the
surface of their RBCs, but their blood serum contains IgM anti-A antibodies and anti-B antibodies against the A
and B blood group antigens. Therefore, a group O individual can receive blood only from a group O individual,
but can donate blood to individuals of any ABO blood group (i.e. A, B, O or AB). If anyone needs a blood
transfusion in an emergency, and if the time taken to process the recipient's blood would cause a detrimental
delay, O Negative blood can be issued.
Table note
1. Assumes absence of atypical antibodies that would cause an incompatibility between donor and recipient blood, as is usual for
blood selected by cross matching.
An Rh D-negative patient who does not have any anti-D antibodies (never being previously sensitized to D-positive
RBCs) can receive a transfusion of D-positive blood once, but this would cause sensitization to the D antigen, and a
female patient would become at risk for hemolytic disease of the newborn. If a D-negative patient has developed anti-D
antibodies, a subsequent exposure to D-positive blood would lead to a potentially dangerous transfusion reaction. Rh
D-positive blood should never be given to D-negative women of child bearing age or to patients with D antibodies, so
blood banks must conserve Rh-negative blood for these patients. In extreme circumstances, such as for a major bleed
when stocks of D-negative blood units are very low at the blood bank, D-positive blood might be given to D-negative
females above child-bearing age or to Rh-negative males, providing that they did not have anti-D antibodies, to
conserve D-negative blood stock in the blood bank. The converse is not true; Rh D-positive patients do not react to D
negative blood. This same matching is done for other antigens of the Rh system as C, c, E and e and for other blood
group systems with a known risk for immunization such as the Kell system in particular for females of child-bearing age
or patients with known need for many transfusions.
Plasma compatibility
Recipients can receive plasma of the same blood group, but otherwise the donor-recipient compatibility for blood
plasma is the converse of that of RBCs: plasma extracted from type AB blood can be transfused to individuals of any
blood group; individuals of blood group O can receive plasma from any blood group; and type O plasma can be used
only by type O recipients.
Table note
1. Assumes absence of strong atypical antibodies in donor plasma
By way of example: considering the transfusion of O Rh D negative blood (universal donor blood) into a recipient of
blood group A Rh D positive, an immune reaction between the recipient's anti-B antibodies and the transfused RBCs is
not anticipated. However, the relatively small amount of plasma in the transfused blood contains anti-A antibodies,
which could react with the A antigens on the surface of the recipients RBCs, but a significant reaction is unlikely because
of the dilution factors. Rh D sensitization is not anticipated.
Additionally, red blood cell surface antigens other than A, B and Rh D, might cause adverse reactions and sensitization,
if they can bind to the corresponding antibodies to generate an immune response. Transfusions are further complicated
because platelets and white blood cells (WBCs) have their own systems of surface antigens, and sensitization to platelet
or WBC antigens can occur as a result of transfusion.
With regard to transfusions of plasma, this situation is reversed. Type O plasma, containing both anti-A and anti-B
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antibodies, can only be given to O recipients. The antibodies will attack the antigens on any other blood type.
Conversely, AB plasma can be given to patients of any ABO blood group due to not containing any anti-A or anti-B
antibodies.
Conversion
In April 2007, a method was discovered to convert blood types A, B, and AB to O, using enzymes. This method is still
experimental and the resulting blood has yet to undergo human trials.[66][67] The method specifically removes or
converts antigens on the red blood cells, so other antigens and antibodies would remain. This does not help plasma
compatibility, but that is a lesser concern since plasma has much more limited clinical utility in transfusion and is much
easier to preserve.
History
The two most significant blood group systems were discovered by Karl Landsteiner during early experiments with blood
transfusion: the ABO group in 1901[68] and in co-operation with Alexander S. Wiener the Rhesus group in 1937.[69]
Development of the Coombs test in 1945,[70] the advent of transfusion medicine, and the understanding of hemolytic
disease of the newborn led to discovery of more blood groups, and now 30 human blood group systems are recognized
by the International Society of Blood Transfusion (ISBT),[2] and across the 30 blood groups, over 600 different blood
group antigens have been found,[4] many of these are very rare or are mainly found in certain ethnic groups. Blood types
have been used in forensic science and were formerly used to demonstrate impossibility of paternity (e.g., a type AB
father cannot be the father of a type O infant), but both of these uses are being replaced by genetic fingerprinting, which
provides greater certainty.[71]
References
1. ^ Maton, Anthea; Jean Hopkins, Charles William McLaughlin, Susan Johnson, Maryanna Quon Warner, David LaHart,
Jill D. Wright (1993). Human Biology and Health. Englewood Cliffs, New Jersey, USA: Prentice Hall. ISBN 0-13-
981176-1.
2. ^ a b c d "Table of blood group systems"
(http://ibgrl.blood.co.uk/isbt%20pages/isbt%20terminology%20pages/table%20of%20blood%20group%20systems.htm)
. International Society of Blood Transfusion. October 2008.
http://ibgrl.blood.co.uk/isbt%20pages/isbt%20terminology%20pages/table%20of%20blood%20group%20systems.htm.
Retrieved 2008-09-12.
3. ^ a b E.A. Letsky; I. Leck, J.M. Bowman (2000). "Chapter 12: Rhesus and other haemolytic diseases". Antenatal &
http://en.wikipedia.org/wiki/Blood_type 10/15
09/12/2010 Blood type - Wikipedia, the free encyc…
neonatal screening (Second ed.). Oxford University Press. ISBN 0-19-262827-7.
4. ^ a b "American Red Cross Blood Services, New England Region, Maine, Massachusetts, New Hampshire, Vermont"
(http://web.archive.org/web/20080621091025/http://www.newenglandblood.org/medical/rare.htm) . American Red
Cross Blood Services - New England Region. 2001. Archived from the original
(http://www.newenglandblood.org/medical/rare.htm) on June 21, 2008.
http://web.archive.org/web/20080621091025/http://www.newenglandblood.org/medical/rare.htm. Retrieved 2008-07-
15. "there are more than 600 known antigens besides A and B that characterize the proteins found on a person's red
cells"
5. ^ Dean, Laura. "The ABO blood group" (http://www.ncbi.nlm.nih.gov/bookshelf/br.fcgi?
book=rbcantigen&part=ch05ABO) . Blood Groups and Red Cell Antigens
(http://www.ncbi.nlm.nih.gov/bookshelf/br.fcgi?book=rbcantigen) . online: NCBI.
http://www.ncbi.nlm.nih.gov/bookshelf/br.fcgi?book=rbcantigen&part=ch05ABO. "A number of illnesses may alter a
person's ABO phenotype"
6. ^ Stayboldt C, Rearden A, Lane TA (1987). "B antigen acquired by normal A1 red cells exposed to a patient's serum".
Transfusion 27 (1): 41–4. doi:10.1046/j.1537-2995.1987.27187121471.x (http://dx.doi.org/10.1046%2Fj.1537-
2995.1987.27187121471.x) . PMID 3810822 (http://www.ncbi.nlm.nih.gov/pubmed/3810822) .
7. ^ Matsushita S, Imamura T, Mizuta T, Hanada M (November 1983). "Acquired B antigen and polyagglutination in a
patient with gastric cancer". The Japanese Journal of Surgery 13 (6): 540–2. doi:10.1007/BF02469500
(http://dx.doi.org/10.1007%2FBF02469500) . PMID 6672386 (http://www.ncbi.nlm.nih.gov/pubmed/6672386) .
8. ^ Kremer Hovinga I, Koopmans M, de Heer E, Bruijn J, Bajema I (2007). "Change in blood group in systemic lupus
erythematosus". Lancet 369 (9557): 186–7; author reply 187. doi:10.1016/S0140-6736(07)60099-3
(http://dx.doi.org/10.1016%2FS0140-6736%2807%2960099-3) . PMID 17240276
(http://www.ncbi.nlm.nih.gov/pubmed/17240276) .
9. ^ Demi-Lee Brennan has changed blood types and immune system
(http://www.news.com.au/entertainment/story/0,26278,23106284-5007185,00.html) Kate Sikora, The Daily Telegraph,
January 25, 2008
10. ^ Aust doctors hail teen's transplant 'miracle' (http://abc.com.au/news/stories/2008/01/24/2146032.htm) Sean
Rubinsztein-Dunlop, ABC News (Australia), January 24, 2008
11. ^ Chown B., Lewis M., Kaita K. (October 1957). "A new Kell blood-group phenotype". Nature 180 (4588): 711.
doi:10.1038/180711a0 (http://dx.doi.org/10.1038%2F180711a0) . PMID 13477267
(http://www.ncbi.nlm.nih.gov/pubmed/13477267) .
12. ^ Miller LH, Mason SJ, Clyde DF, McGinniss MH (August 1976). "The resistance factor to Plasmodium vivax in
blacks. The Duffy-blood-group genotype, FyFy". The New England Journal of Medicine 295 (6): 302–4.
doi:10.1056/NEJM197608052950602 (http://dx.doi.org/10.1056%2FNEJM197608052950602) . PMID 778616
(http://www.ncbi.nlm.nih.gov/pubmed/778616) .
13. ^ Kwiatkowski DP (August 2005). "How malaria has affected the human genome and what human genetics can teach
us about malaria" (http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1224522) . American
Journal of Human Genetics 77 (2): 171–92. doi:10.1086/432519 (http://dx.doi.org/10.1086%2F432519) .
PMID 16001361 (http://www.ncbi.nlm.nih.gov/pubmed/16001361) . "The different geographic distributions of α
thalassemia, G6PD deficiency, ovalocytosis, and the Duffy-negative blood group are further examples of the general
principle that different populations have evolved different genetic variants to protect against malaria".
14. ^ "Your blood – a textbook about blood and blood donation"
(http://web.archive.org/web/20080626184746/http://www.bloddonor.dk/fileadmin/Fil_Arkiv/PDF_filer/Andre/Your_Blo
od__June_2006.pdf) (PDF). p. 63. Archived from the original
(http://www.bloddonor.dk/fileadmin/Fil_Arkiv/PDF_filer/Andre/Your_Blood__June_2006.pdf) on June 26, 2008.
http://web.archive.org/web/20080626184746/http://www.bloddonor.dk/fileadmin/Fil_Arkiv/PDF_filer/Andre/Your_Bloo
d__June_2006.pdf. Retrieved 2008-07-15.
15. ^ Talaro, Kathleen P. (2005). Foundations in microbiology (5th ed.). New York: McGraw-Hill. pp. 510–1. ISBN 0-07-
111203-0.
16. ^ Moise KJ (July 2008). "Management of rhesus alloimmunization in pregnancy". Obstetrics and Gynecology 112 (1):
164–76. doi:10.1097/AOG.0b013e31817d453c (http://dx.doi.org/10.1097%2FAOG.0b013e31817d453c) .
PMID 18591322 (http://www.ncbi.nlm.nih.gov/pubmed/18591322) .
17. ^ "Rh血型的由來" (http://hospital.kingnet.com.tw/activity/blood/html/a.html) . Hospital.kingnet.com.tw.
http://hospital.kingnet.com.tw/activity/blood/html/a.html. Retrieved 2010-08-01.
18. ^ CIA World Factbook (https://www.cia.gov/library/publications/the-world-factbook/fields/2119.html)
19. ^ "Blood Types - What Are They?, Australian Red Cross"
(http://web.archive.org/web/20080719103729/http://giveblood.redcross.org.au/page.aspx?
IDDataTreeMenu=42&parent=30) . Giveblood.redcross.org.au. Archived from the original
(http://www.giveblood.redcross.org.au/page.aspx?IDDataTreeMenu=42&parent=30) on July 19, 2008.
http://web.archive.org/web/20080719103729/http://giveblood.redcross.org.au/page.aspx?
http://en.wikipedia.org/wiki/Blood_type 11/15
09/12/2010 Blood type - Wikipedia, the free encyc…
IDDataTreeMenu=42&parent=30. Retrieved 2010-08-01.
20. ^ "Austrian Red Cross - Blood Donor Information" (http://old.roteskreuz.at/47_body.html#blutgruppen) .
Old.roteskreuz.at. 2006-03-21. http://old.roteskreuz.at/47_body.html#blutgruppen. Retrieved 2010-08-01.
21. ^ "Rode Kruis Wielsbeke - Blood Donor information material" (http://www.rodekruiswielsbeke.be/infobloed.html) .
Rodekruiswielsbeke.be. http://www.rodekruiswielsbeke.be/infobloed.html. Retrieved 2010-08-01.
22. ^ Tipos Sanguíneos (http://www.hemoam.org.br/?secao=sangue_tipos)
23. ^ Canadian Blood Services - Société canadienne du sang. "Types & Rh System, Canadian Blood Services"
(http://www.bloodservices.ca/CentreApps/Internet/UW_V502_MainEngine.nsf/page/Blood%20Types%20and%20Rh%2
0System?OpenDocument) . Bloodservices.ca.
http://www.bloodservices.ca/CentreApps/Internet/UW_V502_MainEngine.nsf/page/Blood%20Types%20and%20Rh%2
0System?OpenDocument. Retrieved 2010-08-01.
24. ^ Frequency of major blood groups in the Danish population. (http://www.bloddonor.dk/index.php?id=513)
25. ^ "Veregruppide esinemissagedus Eestis" (http://www.kliinikum.ee/verekeskus/index.php?menu=9&mod=page&id=5) .
Kliinikum.ee. http://www.kliinikum.ee/verekeskus/index.php?menu=9&mod=page&id=5. Retrieved 2010-08-01.
26. ^ "Suomalaisten veriryhmäjakauma" (http://www.veripalvelu.fi/asp/system/empty.asp?
P=1275&VID=default&SID=908029945449597&S=1&C=24395) . Veripalvelu.fi. 2009-08-21.
http://www.veripalvelu.fi/asp/system/empty.asp?P=1275&VID=default&SID=908029945449597&S=1&C=24395.
Retrieved 2010-08-01.
27. ^ "Les groupes sanguins (système ABO)" (http://www.chpg.mc/go/article.php3?id_article=111) (in French). Le Centre
Hospitalier Princesse Grace - Monaco. C.H.P.G. MONACO. 2005. http://www.chpg.mc/go/article.php3?id_article=111.
Retrieved 2008-07-15.
28. ^ Häufigkeit der Blutgruppen
http://en.wikipedia.org/wiki/Blood_type 12/15
09/12/2010 Blood type - Wikipedia, the free encyc…
http://www.blood.co.uk/pages/all_about.html. Retrieved 2010-08-01.
46. ^ "Blood Types in the U.S" (http://bloodcenter.stanford.edu/about_blood/blood_types.html) . Bloodcenter.stanford.edu.
2008-06-20. http://bloodcenter.stanford.edu/about_blood/blood_types.html. Retrieved 2010-08-01.
47. ^ "Racial and ethnic distribution of ABO blood types" (http://www.bloodbook.com/world-abo.html) . Bloodbook.com.
http://www.bloodbook.com/world-abo.html. Retrieved 2010-08-01.
48. ^ Blood Transfusion Division, United States Army Medical Research Laboratory (1971). Selected contributions to the
literature of blood groups and immunology. 1971 v. 4 (http://books.google.com/?id=ALilcA7Acd0C) . United States
Army Medical Research Laboratory, Fort Knox, Kentucky. http://books.google.com/?id=ALilcA7Acd0C. "... In
northern India, in Southern and Central China and in the neighboring Central Asiatic areas, we find the highest known
frequencies of B. If we leave this center, the frequency of the B gene decreases almost everywhere ... "
49. ^ a b Encyclopaedia Britannica (2002). The New Encyclopaedia Britannica (http://books.google.com/?
id=fpdUAAAAMAAJ) . Encyclopaedia Britannica, Inc.. ISBN 0852297874. http://books.google.com/?
id=fpdUAAAAMAAJ. "... The maximum frequency of the B gene occurs in Central Asia and northern India. The B gene
was probably absent from American Indians and Australian Aborigines before racial admixture occurred with the
coming of the white man ... "
50. ^ Carol R. Ember, Melvin Ember (1973). Anthropology (http://books.google.com/?id=fvpFAAAAMAAJ) . Appleton-
Century-Crofts. http://books.google.com/?id=fvpFAAAAMAAJ. "... Blood type B is completely absent in most North
and South American Indians ... "
51. Laura Dean, MD (2005). Blood Groups an Red Cell Antigens (http://www.ncbi.nlm.nih.gov/bookshelf/br.fcgi?
^
book=rbcantigen) . National Center for Biotechnology Information, United States Government. ISBN 1932811052.
http://www.ncbi.nlm.nih.gov/bookshelf/br.fcgi?book=rbcantigen. "... Type A is common in Central and Eastern
Europe. In countries such as Austria, Denmark, Norway, and Switzerland, about 45-50% of the population have this
blood type, whereas about 40% of Poles and Ukrainians do so. The highest frequencies are found in small, unrelated
populations. For example, about 80% of the Blackfoot Indians of Montana have blood type A ... "
52. ^ (PDF) Technical Monograph No. 2: The ABO Blood Group System and ABO Subgroups
(http://www.biotec.com/pdf/Technical%20Monograph%20No.%202%20-
%20ABO%20system%20and%20subgroups.pdf) . Biotec. March 2005.
http://www.biotec.com/pdf/Technical%20Monograph%20No.%202%20-
%20ABO%20system%20and%20subgroups.pdf. "... The frequency of blood group A is quite high (25-55%) in Europe,
especially in Scandinavia and parts of central Europe. High group A frequency is also found in the Aborigines of South
Australia (up to 45%) and in certain American Indian tribes where the frequency reaches 35% ..."
53. ^ Possible Risks of Blood Product Transfusions
(http://www.cancer.org/docroot/ETO/content/ETO_1_4x_Possible_Risks_of_Blood_Product_Transfusions.asp) from
American Cancer Society. Last Medical Review: 03/08/2008. Last Revised: 01/13/2009
54. ^ 7 adverse reactions to transfusion (http://www.pathology.med.umich.edu/bloodbank/manual/bbch_7/index.html)
Pathology Department at University of Michigan. Version July 2004, Revised 11/5/08
55. ^ Nickel RG, Willadsen SA, Freidhoff LR, et al. (August 1999). "Determination of Duffy genotypes in three populations
of African descent using PCR and sequence-specific oligonucleotides". Human Immunology 60 (8): 738–42.
doi:10.1016/S0198-8859(99)00039-7 (http://dx.doi.org/10.1016%2FS0198-8859%2899%2900039-7) .
PMID 10439320 (http://www.ncbi.nlm.nih.gov/pubmed/10439320) .
56. ^ Bruce, MG (May 2002). "BCF - Members - Chairman's Annual Report"
(http://www.bloodcare.org.uk/html/resources_chairman_2001.htm) . The Blood Care Foundation.
http://www.bloodcare.org.uk/html/resources_chairman_2001.htm. Retrieved 2008-07-15. "As Rhesus Negative blood is
rare amongst local nationals, this Agreement will be of particular value to Rhesus Negative expatriates and travellers"
57. ^ Daniels G, Finning K, Martin P, Summers J (September 2006). "Fetal blood group genotyping: present and future".
Annals of the New York Academy of Sciences 1075: 88–95. doi:10.1196/annals.1368.011
(http://dx.doi.org/10.1196%2Fannals.1368.011) . PMID 17108196 (http://www.ncbi.nlm.nih.gov/pubmed/17108196) .
58. ^ "Use of Anti-D Immunoglobulin for Rh Prophylaxis" (http://www.rcog.org.uk/index.asp?PageID=1972) . Royal
College of Obstetricians and Gynaecologists. May 2002. http://www.rcog.org.uk/index.asp?PageID=1972.
59. ^ "Pregnancy - routine anti-D prophylaxis for D-negative women" (http://www.nice.org.uk/guidance/TA41/?c=91520) .
NICE. May 2002. http://www.nice.org.uk/guidance/TA41/?c=91520.
60. ^ "RBC compatibility table" (http://chapters.redcross.org/br/northernohio/INFO/bloodtype.html) . American National
Red Cross. December 2006. http://chapters.redcross.org/br/northernohio/INFO/bloodtype.html. Retrieved 2008-07-15.
61. ^ a b Blood types and compatibility (http://www.bloodbook.com/compat.html) bloodbook.com
62. ^ Fauci, Anthony S.; Eugene Braunwald, Kurt J. Isselbacher, Jean D. Wilson, Joseph B. Martin, Dennis L. Kasper,
Stephen L. Hauser, Dan L. Longo (1998). Harrison's Principals of Internal Medicine. New York: McGraw-Hill.
pp. 719.. ISBN 0-07-020291-5.)
63. ^ "Universal acceptor and donor groups" (http://www.webmd.com/a-to-z-guides/blood-type-test) . Webmd.com. 2008-
06-12. http://www.webmd.com/a-to-z-guides/blood-type-test. Retrieved 2010-08-01.
64. ^ Anstee DJ (2009). "Red cell genotyping and the future of pretransfusion testing". Blood 114 (2): 248–56.
http://en.wikipedia.org/wiki/Blood_type 13/15
09/12/2010 Blood type - Wikipedia, the free encyc…
doi:10.1182/blood-2008-11-146860 (http://dx.doi.org/10.1182%2Fblood-2008-11-146860) . PMID 19411635
(http://www.ncbi.nlm.nih.gov/pubmed/19411635) .
65. ^ Avent ND (2009). "Large-scale blood group genotyping: clinical implications". Br J Haematol 144 (1): 3–13.
doi:10.1111/j.1365-2141.2008.07285.x (http://dx.doi.org/10.1111%2Fj.1365-2141.2008.07285.x) . PMID 19016734
(http://www.ncbi.nlm.nih.gov/pubmed/19016734) .
66. ^ "Blood groups 'can be converted'" (http://news.bbc.co.uk/1/hi/health/6517137.stm) . BBC News. 2007-04-02.
http://news.bbc.co.uk/1/hi/health/6517137.stm. Retrieved 2008-07-15.
67. ^ Liu Q, Sulzenbacher G, Yuan H, Bennett E, Pietz G, Saunders K, Spence J, Nudelman E, Levery S, White T, Neveu
J, Lane W, Bourne Y, Olsson M, Henrissat B, Clausen H (2007). "Bacterial glycosidases for the production of universal
red blood cells". Nat Biotechnol 25 (4): 454. doi:10.1038/nbt1298 (http://dx.doi.org/10.1038%2Fnbt1298) .
PMID 17401360 (http://www.ncbi.nlm.nih.gov/pubmed/17401360) .
68. ^ Landsteiner K. Zur Kenntnis der antifermentativen, lytischen und agglutinierenden Wirkungen des Blutserums und der
Lymphe. Zentralblatt Bakteriologie 1900;27:357-62.
69. ^ Landsteiner K, Wiener AS. An agglutinable factor in human blood recognized by immune sera for rhesus blood. Proc
Soc Exp Biol Med 1940;43:223-224.
70. ^ Coombs RRA, Mourant AE, Race RR. A new test for the detection of weak and "incomplete" Rh agglutinins. Brit J
Exp Path 1945;26:255-66.
71. ^ Johnson P, Williams R, Martin P (2003). "Genetics and Forensics: Making the National DNA Database"
(http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1351151) . Science Studies 16 (2): 22–
37. PMID 16467921 (http://www.ncbi.nlm.nih.gov/pubmed/16467921) .
72. ^ a b c "Myth about Japan blood types under attack" (http://aol.mediresource.com/channel_health_news_details.asp?
news_id=6661&news_channel_id=11&channel_id=11) . Associated Press. AOL Health. 2005-05-06.
http://aol.mediresource.com/channel_health_news_details.asp?news_id=6661&news_channel_id=11&channel_id=11.
Retrieved 2007-12-29.
Further reading
Dean, Laura. "Blood Groups and Red Cell Antigens, a guide to the differences in our blood types that complicate
blood transfusions and pregnancy." (http://www.ncbi.nlm.nih.gov/bookshelf/br.fcgi?book=rbcantigen) (HTML,
also PDF, Flash and PRC versions). National Center for Biotechnology Information.
http://www.ncbi.nlm.nih.gov/bookshelf/br.fcgi?book=rbcantigen. Retrieved September 15, 2006.
Mollison PL, Engelfriet CP and Contreras M. Blood Transfusion in Clinical Medicine. 1997. 10th edition.
Blackwell Science, Oxford, UK. ISBN 0-86542-881-6.
External links
BGMUT (http://www.ncbi.nlm.nih.gov/gv/mhc/xslcgi.cgi?cmd=bgmut/home) Blood Group Antigen Gene
Mutation Database at NCBI, NIH has details of genes and proteins, and variations thereof, that are responsible
for blood types
Online 'Mendelian Inheritance in Man' (OMIM) 110300 (http://www.ncbi.nlm.nih.gov/omim/110300) (ABO)
Online 'Mendelian Inheritance in Man' (OMIM) 111680 (http://www.ncbi.nlm.nih.gov/omim/111680) (Rhesus
D)
Farr AD (April 1979). "Blood group serology--the first four decades (1900--1939)"
(http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1082436) . Medical History 23 (2):
215–26. PMID 381816 (http://www.ncbi.nlm.nih.gov/pubmed/381816) .
"Blood group test, Gentest.ch" (http://www.gentest.ch/index.php?content=bloodtype&langchange=en) (HTML,
JavaScript). Gentest.ch GmbH. http://www.gentest.ch/index.php?content=bloodtype&langchange=en. Retrieved
2006.
"Blood typing systems other than ABO" (http://www.bloodbook.com/type-sys.html) . BloodBook.com. 2005-
09-10. http://www.bloodbook.com/type-sys.html. Retrieved 2008-07-15.
"Blood Facts - Rare Traits" (http://www.lifeshare.org/facts/raretraits.htm) . LifeShare Blood Centers.
http://www.lifeshare.org/facts/raretraits.htm. Retrieved September 15, 2006.
"Modern Human Variation: Distribution of Blood Types"
(http://web.archive.org/web/*/http://anthro.palomar.edu/vary/vary_3.htmhttp://web.archive.org/web/*/http://anthr
o.palomar.edu/vary/vary_3.htm) . Dr. Dennis O'Neil, Behavioral Sciences Department, Palomar College, San
http://en.wikipedia.org/wiki/Blood_type 14/15
09/12/2010 Blood type - Wikipedia, the free encyc…
Marcos, California. 2001-06-06. Archived from the original (http://anthro.palomar.edu/vary/vary_3.htm) on
2006-02-21.
http://web.archive.org/web/*/http://anthro.palomar.edu/vary/vary_3.htmhttp://web.archive.org/web/*/http://anthro
.palomar.edu/vary/vary_3.htm. Retrieved November 23, 2006.
"Racial and Ethnic Distribution of ABO Blood Types - BloodBook.com, Blood Information for Life"
(http://www.bloodbook.com/world-abo.html) . bloodbook.com. http://www.bloodbook.com/world-abo.html.
Retrieved September 15, 2006.
"Molecular Genetic Basis of ABO" (http://abobloodgroup.googlepages.com/home) .
http://abobloodgroup.googlepages.com/home. Retrieved July 31, 2008.
Blood Type Calculator (http://www.etoolsage.com/Calculator/Blood_Type_Calculator.asp) -The calculator is
used to determine the blood type of child when the blood type of parents are known.
Retrieved from "http://en.wikipedia.org/wiki/Blood_type"
Categories: Blood | Genetics | Hematology | Transfusion medicine
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