Professional Documents
Culture Documents
Gentamicin
Dose according to age, weight
and renal function as per
Therapeutic Guidelines
IF VASCULAR ACCESS LINE Antibiotic. Monitor levels.
Age <30years - 6mg/kg
OR PORT SEPSIS is Age 30 to 60 years - 5mg/kg
suspected Age >60years - 4mg/kg
Add Vancomycin (to the above
regimen) 1g IV every 12 hours Vancomycin
(modify dose in renal impairment) Infuse slowly at 10mg/minute,
monitor blood levels and adjust
dose accordingly, see
Therapeutic Guidelines
Antibiotic-Monitoring and
dosing of vancomycin
IF CLINICAL OROPHARYNGEAL
CANDIDIASIS OR RECENT HIGH DOSE
STEROIDS
Add Fluconazole 400mg IV
or orally every 24 hours
NOTE:
1. Antibiotics should be modified on the basis of culture results.
2. Management of unresolving fever in the context of neutropenia should not be a matter of routine
following of an antibiotic protocol, but should be based on daily clinical assessment, daily assessment of
the full blood count, regular review of culture results, with repeated cultures and other investigations as
required.
3. High resolution CT of the chest is often helpful if there is ongoing fever.
4. The choice of antibiotics should always be modified according to clinical circumstances, e.g. if chest
infection is strongly suspected at the outset, consideration should be given to pathogens such as
Legionella and to the possibility of pneumocystis pneumonia.
Reference: Therapeutic Guidelines-Antibiotic 2006. Severe sepsis – febrile neutropenic patients. Pages 257-258