Professional Documents
Culture Documents
1. The table below refers to the formula and structure of some biological molecules.
Complete the table by writing in the name, the formula or the structure of the molecule where
appropriate in the empty boxes.
Water H2O
NH2RCHCOOH
H H H H H O
H C C C C C C
Fatty acid
H H H H H O H
C H 2O H
C O
H H
H
C C
O H H
H O O H
C C
H O H
(Total 6 marks)
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(c) Describe how the structure of a fibrous protein, such as collagen, differs from the
structure of a globular protein.
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(3)
(Total 8 marks)
3. Urease is an enzyme which catalyses the breakdown of urea to ammonia and carbon dioxide.
An experiment was carried out into the effect of pH on the activity of urease. 10 cm3 of pH 3
buffer solution was mixed with 1 cm3 of urease solution. This mixture was then added to
10 cm3 of urea solution and the concentration of ammonia in the mixture was measured after 60
minutes. This procedure was repeated using buffer solutions of pH 4, 5, 6, 7, 8 and 9.
100
80
60
C o n c e n tra tio n
o f a m m o n ia /
a rb itra ry u n its
40
20
0
3 4 5 6 7 8 9
pH
Tadcaster Grammar School 2
(a) What do these results suggest is the optimum pH for urease activity?
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(1)
(b) Suggest how the experiment could be modified to determine the optimum pH more
accurately.
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(e) Describe how this experiment could be modified to determine the effect of enzyme
concentration on the activity of urease.
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(Total 11 marks)
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B C
A
A ................................................................................................................................
B ................................................................................................................................
C ................................................................................................................................
(3)
(b) Each time the heart beats, the atria contract first and then the ventricles contract. Explain
how this sequence of events is coordinated.
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(Total 7 marks)
1 0 0 0 –
8 0 0 –
N u m 6 b 0 e 0r –
o f
W o m e n
d
e a t h s
p e r
1 0 0 0 0 0 M e n
p o p u 4l a 0 t 0i o n–
2 0 0 –
0 –
–
–
–
–
–
F r a n c e S p R a ui n s s i a E n g l a n d
a n d W a l e s
(a) Describe the differences in the death rates shown in the chart above.
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(3)
(b) One possible reason for the differences in the death rates due to cardiovascular disease
between the different countries is the quantity of fruit and vegetables eaten.
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(Total 8 marks)
Z
X
A d e n i n e
W C y t o s i n e
(a) (i) Name the parts of the molecule represented by each of the following letters.
V ……………………………………………………………………………..
W ......................................................................................................................
X ......................................................................................................................
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(5)
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(1)
(b) The table below shows the amino acids coded by mRNA codons.
S e c o n d b a s e
U C
U U UP h e n y lU a lC a UnS i e n r e i n Ue A UT y r o s i Un eG UC y s t e i nU e
U U U CP h e n y lU a lC a CnS i e n r e i n Ue A CT y r o s i Un eG CC y s t e i nC e
U U AL e u c i nU e C AS e r i n Ue A AS t o p U G AS t o p A
U U GL e u c i nU e C GS e r i n Ue A GS t o p U G GT r y p t o Gp h a n
C U UL e u c i n C e C UP r o l i Cn eA UH i s t i d Ci n G e UA r g i n i nU e
C U CL e u c i n C e C CP r o l i Cn eA CH i s t i d Ci n G e CA r g i n i nC e
C
T h ird b a s e
C U AL e u c i n C e C AP r o l i Cn eA AG l u t a m C iGn eA A r g i n i nA e
F irs t b a s e
C U GL e u c i n C e C GP r o l i Cn eA GG l u t a m C iGn eG A r g i n i nG e
A U UI s o l e u cA i nC e UT h r e Ao n A i n UA e s p a r aA g G i n US e e r i n e U
A A U CI s o l e u cA i nC e CT h r e Ao n A i n CA e s p a r aA g G i n CS e e r i n e C
A U AI s o l e u cA i nC e AT h r e Ao n A i n AL e y s i n eA G AA r g i n i nA e
A U GM e t h i oA n Ci n GT e h r e Ao n A i n GL e y s i n eA G GA r g i n i nG e
G U UV a l i n e G C UA l a n Gi n Ae UA s p a r tG i c G a UG c i l dy c i n Ue
G U CV a l i n e G C CA l a n Gi n Ae CA s p a r tG i c G a CG c i l dy c i n Ce
G G U AV a l i n e G C AA l a n Gi n Ae AG l u t a m G i Gc AGa c l iy d c i n Ae
G U GV a l i n e G C GA l a n Gi n Ae GG l u t a m G i Gc GGa c l iy d c i n Ge
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(1)
(ii) Reading from left to right, what is the sequence of amino acids coded by the
following length of mRNA?
G A U C G U U G U A A G
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(1)
(iii) A mutation occurred so that the base cytosine was replaced by guanine in this
mRNA. Using the information in the table, explain why this mutation could affect
the tertiary structure of the protein formed from this mRNA.
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(3)
THE END (Total 11 marks)