This document summarizes several common analgesic and sedative drugs used in veterinary medicine, including opioids (morphine, oxymorphone, meperidine, fentanyl, butorphanol, buprenorphine), alpha-2 agonists (xylazine, meditomidine), nonsteroidal anti-inflammatory drugs (aspirin, acetaminophen, ibuprofen, flunixin, ketoprofen, carprofen, meloxicam), and local anesthetics (lidocaine). It provides information on indications, administration routes, duration of action, side effects, and cautions for each drug.
This document summarizes several common analgesic and sedative drugs used in veterinary medicine, including opioids (morphine, oxymorphone, meperidine, fentanyl, butorphanol, buprenorphine), alpha-2 agonists (xylazine, meditomidine), nonsteroidal anti-inflammatory drugs (aspirin, acetaminophen, ibuprofen, flunixin, ketoprofen, carprofen, meloxicam), and local anesthetics (lidocaine). It provides information on indications, administration routes, duration of action, side effects, and cautions for each drug.
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This document summarizes several common analgesic and sedative drugs used in veterinary medicine, including opioids (morphine, oxymorphone, meperidine, fentanyl, butorphanol, buprenorphine), alpha-2 agonists (xylazine, meditomidine), nonsteroidal anti-inflammatory drugs (aspirin, acetaminophen, ibuprofen, flunixin, ketoprofen, carprofen, meloxicam), and local anesthetics (lidocaine). It provides information on indications, administration routes, duration of action, side effects, and cautions for each drug.
Copyright:
Attribution Non-Commercial (BY-NC)
Available Formats
Download as DOCX, PDF, TXT or read online from Scribd
Acts on pain Morphine Stimulates vomiting and vagal receptors in both CNS centers; Can cause spinal cord and excitement in cats, horses and brain; May be used food animals; 4-6 hours duration; with tranquilizers to May be given SC or IM to help induce a state of prevent hypotension; For potent sedation moderate to severe pain (neuroleptanalgesia) Oxymorphone Greater analgesic and sedative effects than morphine; Does not cause hypotension; May cause excitement in cats; May be given IV, SC, IM, or epidurally; Approximate 4 hour duration; For moderate to severe pain Meperidine Rapid IV injection may cause (Demerol) severe hypotension, excitement and seizures; Painful if given IM; Preferred administration is SC; Used in dogs, cats, and rodents; A synthetic opioid; not as potent as above drugs; Often used with NSAIDs or as a preanesthetic; For mild to moderate pain Fentanyl One of the most potent analgesics; Rapid onset-short duration (IV injection = 30 minutes); Usually administered by continuous IV drip or transdermal patch; Can cause panting and increased sensitivity to sound; For severe to moderate pain Butorphanol Synthetic opioid- has both agonist (Torbutrol) and antagonist properties; Effective and safe post-op analgesic for mild to moderate pain, especially cranial visceral; Extensively used in dogs, cats, and horses; May be used to help reverse effects of other opioids (respiratory depression and sedation), while still maintaining some analgesia; Do not give epidurally±potentially toxic to the spinal cord Buprenorphine A partial agonist; Has a bell shaped response curve (may be less effective at higher doses than at moderate doses); Delayed onset, but gives 6-12 hours analgesia(IM) and 18-24 hours when given epidurally; Not adequate for severe pain (i.e. orthopedic pain), but is useful for mild to moderate pain; Commonly used for rodents and other species in research; Has been known to cause pica in rats c Profound sedative Xylazine May be used alone or in effect; Rapid onset; combination with other agents Reliable, reversible; (i.e. Ketamine, opioids) IM or IV; !! Good muscle Will allow greatly reduced doses relaxation; May of other agents including cause cardiovascular inhalants; May cause vomiting side effects; Use and bloat (in ruminants); Can be only in healthy reversed with Yohimbine (IV) animals; Not for very young or very old; Use caution when handling-may be absorbed through skin abrasions; Causes transient hypoglycemia Meditomidine Commonly used in combination (Domitor) with other agents (dose of general anesthetic should be reduced); Less likely to cause vomiting; May be reversed with Atipamesole (Antesedan) which will not reverse the effects of other drugs given concurrently with Meditomidine; *High doses of Atipamesole can cause panting, excitement, muscle tremors, hypotension, and tachycardia-especially if given IV c Analgesic, Aspirin May cause gastric irritation and " # antipyretic, and anti- prolonged bleeding time; inflammatory; Prolonged half life in cats, # Effective for geriatrics and neonates $% musculoskeletal
& pain; Requires 30-60 minutes for full analgesic properties to take effect; Metabolized in the liver; Negligible effect on cardiovascular and respiratory systems Acetaminophen Toxic to cats and hepatotoxic to dogs; Less gastric irritation than Aspirin Ibuprofen Renal, gastric effects; Narrow safety margin in cats Flunixin Significant renal toxicity is (Banamine) possible in hypotensive patients; Do not use with Methoxyflurane Ketoprofen Potent analgesic, especially for orthopedic patients; Gastric irritation and ulceration may occur at therapeutic doses Carprofen Less potential for gastric (Rimadyl) ulceration than some NSAID¶s; Renal toxicity seen in dogs with prolonged use (especially Labrador Retrievers) Meloxicam Can cause vomiting and diarrhea; Less potential for gastric ulceration than some NSAID¶s; 5-day limit for treatment of cats Can be sprayed, Lidocaine Immediate onset; Lasts about 1-2 c injected at surgical (Xylocaine) hours (with epinephrine) or 1 site, or infiltrated hour without around a nerve supplying the affected area; May be used to desensitize an entire area by using an epidural injection Bupivicaine Onset 20 min; Duration 4-6 hours Mepivicaine Immediate onset; Duration 90- 180 minutes Novocaine Topical (mucous membranes) and injectable forms; Immediate onset; Duration 1 hour Ophthane For ophthalmic use
* Must be handled in accordance with the Control Drug Act