TEST 5 GIT, RESPIRATION, ANTIEMETICS

MPhil. Part 1
Maximum Marks 70, Time 75 Minutes
1.
a) A patients with chronic severe asthma is inadequately controlled by high-dose inhaled
corticosteroid plus long-acting Beta2-agonist combination treatment, suggest the drug to be
used in this situation also give its mechanism of action 3
b) Give the rationale of use of Beta2 stimulants for the treatment of Asthma in detail
4
c) Enumerate the drugs used in allergic rhinitis 3
2.
a) Give the treatment for Apnea of Preterm Infants; write the mechanism of action of any drug
you suggest 3
b) Classify anti-tussive drugs, give the drug interactions and adverse effects of each group
3
c) Cromolyn Sodium and Nedocromil Sodium are used in asthma; outline their mechanism and
usefulness in this condition, what are advantages and limitations of Nedocromil Sodium? 4
3.
a) A patient comes with status asthmaticus, what are the drugs used to treat this condition? 3
b) Antimuscarinics can be used to treat asthma, what is the rationale of this use, what routes
can be adopted for their administration, what other reparatory conditions can be treated by
them? 4
c) Give the advantages of Leukotriene Antagonists used in asthma. 3
4
a) Give the rationale of use of H2 antagonists in hyper-acidity states, give their adverse
effects and drug interactions 4
b) Give the mechanism of action, drug interaction and uses of sucralfate 3
c) Enumerate the gastric mucosal protective agents 3

5.
a) Tabulate the drugs used to relieve constipation giving their brief mechanism and adverse
effects. 4
b) Give the mechanism of action clinical uses and adverse effects of Tegaserod 3
c) Classify anti-diarrheals 3

6.
a) A 28 years old pregnant lady suffers with hyperemesis, she is advised ondansetron, what is
the mechanism of actions, adverse effects and other clinical uses of this drug? 3
b) Dronabinol is a naturally occurring cannabinoid, give its mechanism of action, adverse
effects and possible therapeutic applications. 3
c) A patient is on chemotherapy and is using cisplatin, he has severe vomiting associated with
his medication, which drug is advised in this condition, give its mechanism of action, dose and
drug interactions 4
7.
a) The bowel follow through results of a 28 years old patient are suggestive of mild Crohn’s
disease. Since he is adverse to the idea of taking steroids, you decide to begin the patient on
a medication that is structurally related to aspirin. What medication is that? What is its
mechanism of action and other uses? 3
b) A 34 years women presents with gastroesophageal reflux disease, you explain to her that
there are several treatment options, including an over-the-counter class of drugs that act as
weak bases to reduce acidity in stomach, enumerate the drugs in that class and also tell her
the possible adverse effect of each drug/s 4
c) A 45 years old man complains of long standing epigastric pain and diarrhea. He took proton
pump inhibitors in past but has not found any relief. Labs reveal elevated serum gastrin and
imaging reveals tumor on small intestine. You explain him the treatment being surgical
resection as well as pharmacological treatment with a synthetic analog of naturally occurring
pancreatic hormone. Which drug is in your mind? What is its mechanism and other uses? 3