Injectables at Glance

Botulinum FDA Approved Purpose Off Label Approx. Duration Side Potential Adverse
Toxin Type A Aproval Date Use Uses Cost* of Results* Effects Outcomes
Botox April 2002 Treating frown Restricts muscle Commonly used on $400 or 3-6 months Bruising, numbness Rarely, immunity if
Cosmetic lines of the glabel- action that result in crow’s feet, forehead more used more frequently
la region (between facial creases or creases, frown lines, (per area) than prescribed
the eyebrows) wrinkles and bands on the neck

Botox 2004 Treatment of Treat overactive Treat overactive sweat- $400 or 3-6 months Bruising, numbness Immunity if used more
Auxiliary sweating of the ing of the palms, scalp, more frequently than pre-
hyperhidrosis underarm forehead, groin and (per area) scribed
soles of the feet

Reloxin Investigational, N/A Restricts muscle N/A N/A 3-6 months Reportedly bruising, Reportedly droopy
pending FDA action that result in numbness eyelid or change in
approval facial creases or facial appearance,
wrinkles immunity if used
more frequently than
prescribed

Hyaluronic FDA Approved Purpose Off Label Approx. Duration Side Potential Adverse
Acid Fillers Aproval Date Use Uses Cost* of Results* Effects Outcomes

Restylane December Treatment of mild Dermal filler, enhances Smoothing facial creases of $600 or 6 months Bruising, swelling, May be visible or
2003 to moderate facial soft tissue volume to the forehead and brow, more or more redness felt if injected
creases smooth wrinkles or plumping the eyebrows or per syringe superficially. In very
add fullness temporal region, smoothing rare cases may
under eye hollows, enhanc- develop nodules
ing the lips and defining a (small bumps
cupid’s bow, enchancing beneath the skin).
volume and defining con-
tours of the cheeks, chin
and jawline, softening the
appearance of scars and
other depressed defects,
softening the appearance
of bony hands

Juvederm June 2006 Treatment of mild Dermal filler, enhances Smoothing facial creases of $600 or 6 months Bruising, swelling, May be visible or felt
(Ultra and to moderate facial soft tissue volume to the forehead and brow, more or more redness if injected superficial-
Ultra Plus) creases smooth wrinkles or plumping the eyebrows or per syringe ly. In very rare cases
add fullness temporal region, smoothing may develop nodules
under eye hollows, enhanc- (small bumps beneath
ing the lips and defining a the skin).
cupid’s bow, enchancing
volume and defining con-
tours of the cheeks, chin
and jawline, softening the
appearance of scars and
other depressed defects,
softening the appearance of
bony hands

Perlane May 2007 Treatment of mild More dense dermal Smoothing facial creases $650 or 6 months Bruising, swelling, May be visible or felt
to moderate facial filler, enhances soft of the forehead and brow, more or more redness if injected superficial-
creases tissue volume to plumping the eyebrows or per syringe ly. In very rare cases
smooth facial creas- temporal region, smooth- may develop nodules
es or add fullness ing under eye hollows, (small bumps
enhancing the lips, beneath the skin).
enchancing volume and
defining contours of the
cheeks, chin and jawline,
softening the appearance
of scars and other
depressed defects, soft-
ening the appearance of
bony hands

Puragen Investigational, N/A Dermal filler with N/A N/A 6 months Bruising, swelling, Reportedly may be
pending FDA added lidocaine or more redness visible or felt if inject-
approval (anesthetic) ed superficially. In
very rare cases may
develop nodules
(small bumps
beneath the skin).

This chart represents U.S. FDA injectables commonly used for cosmetic purposes by plastic surgeons, facial plastic surgeons, ophthalmic plastic surgeons and dermatologists, and those in patient
clinical trials of investigation. Not all U.S. FDA approved injectables, or those in research and development are included.
*Pricing may vary per physician and by treatment location. *Duration of results varies based on the individual patient.
(chart continued on other side)
 Injectables at Glance
Hyaluronic FDA Approved Purpose Off Label Approx. Duration Side Potential Adverse
Acid Fillers Aproval Date Use Uses Cost* of Results* Effects Outcomes
Restylane Investigational, N/A More fluid dermal N/A N/A 6 months Reportedly bruising, Reportedly may be visi-
Touch pending FDA filler for areas with swelling, redness ble or felt if injected
(previously approval thinner skin and superficially. In very
Restylane smaller wrinkles or rare cases may develop
Fine Lines) dermal defects nodules (small bumps
beneath the skin).

Elevess December 2006 Treatment of mild Dermal filler with Smoothing facial creases of N/A 6 months Bruising, swelling, May be visible or felt
(previously to moderate facial added anesthetic, the forehead and brow, or more redness if injected superficial-
Anika CTA) creases enhances soft tissue plumping the eyebrows or ly. In very rare cases
volume to smooth temporal region, smoothing may develop nodules
wrinkles or add full- under eye hollows, enhanc- (small bumps
ness ing the lips and defining a beneath the skin).
cupid’s bow, enchancing
volume and defining con-
tours of the cheeks, chin
and jawline, softening the
appearance of scars and
other depressed defects,
softening the appearance
of bony hands
Collagen FDA Approved Purpose Off Label Approx. Duration Side Potential Adverse
Fillers Aproval Date Use Uses Cost* of Results* Effects Outcomes

Cosmoplast/ March 2003 Soft tissue aug- Filling and smoothing Any area not on the face $500 or 3 to 4 months Swelling, redness, Small, temporary
Cosmoderm mentation and der- fine lines, defining the more per may alter the hue of bumps beneath the
mal filler lip border and enhanc- syringe skin of color if skin
ing lip volume, soften- injected superficially
ing the appearance of
scars and other
depressed defects

Zyderm/ 1981/1985 Filling fine lines and Filling and smoothing Any area not on the face $500 or 3 to 4 months Potential for allergic Small, temporary
Zyplast wrinkles, defining fine lines, defining the more per reaction, pre-allergy bumps beneath the
the lip border lip border and enhanc- syringe testing required; skin
ing lip volume, soften- bruising, swelling,
ing the appearance of redness
scars and other
depressed defects

Evolence Investigational, N/A Dermal filler, restor- N/A N/A Reportedly 6 Reportedly bruising, Reportedly may be
pending FDA ing volume and col- months or swelling, redness felt or develop small
approval lagen loss more lumps

Synthetic FDA Approved Purpose Off Label Approx. Duration Side Potential Adverse
Fillers Aproval Date Use Uses Cost* of Results* Effects Outcomes
Artefill October 2006 Correction of facial Dermal filler Adding volume and full- $500 or Up to 5 years Potential for allergic May be visible or felt. In
(polymethyl- wrinkles and folds ness to facial features more or more reaction, pre-allergy rare cases may develop
methacrylate and contours per syringe testing required; nodules (small bumps
suspended in bruising, swelling, beneath the skin)
bovine collagen) redness
Radiesse December 2006 Correction of facial Dermal filler Adding volume and full- $850 or 12 months or Bruising, swelling, May be visible or felt. In
(calcium wrinkles and folds ness to facial features more per more redness rare cases may develop
hydroxylapatite) and HIV Facial and contours syringe nodules (small bumps
Wasting beneath the skin)

Sculptra August 2004 Treatment of lipoat- Dermal filler Adding volume and full- $2500 or 12 months or Bruising, swelling, May be visible or felt.
(Poly-L-lactic rophy (loss of facial ness to facial features more per more redness In rare cases may
acid) fat) in HIV positive and contours on non-HIV treatment develop nodules
individuals individuals (small bumps beneath
the skin)

SilSkin Investigational N/A Facial soft tissue N/A N/A Permanent Bruising, swelling, Cannot be removed.
(silicone oil) augmentation redness Reportedly may be felt,
seen or migrate (travel)
in the skin. Reportedly
can result in ulcers of
the skin, intermittent or
permanent redness
and swelling

This chart represents U.S. FDA injectables commonly used for cosmetic purposes by plastic surgeons, facial plastic surgeons, ophthalmic plastic surgeons and dermatologists, and those in patient
clinical trials of investigation. Not all U.S. FDA approved injectables, or those in research and development are included.
*Pricing may vary per physician and by treatment location. *Duration of results varies based on the individual patient.
(chart begins on other side)