Generic Name

Amoxicillin
Brand Name Amoxil, Trimox
Classification Anti-bacterial
Dosage 500mg/cm
Mode of Action Inhibits the cell wall synthesis of bacterial cells.
Indication Treatment of ear, nose, throat, GU, skin and skin structure, lower respiratory tract, and acute

uncomplicated gonorrhea infections caused by susceptible strains of specific organisms. In

combination with clarithromycin and/or lansoprazole for the eradication of H. pylori .

Contraindications Hypersensitivity to penicillins, cephalosporins, or imipenem.

Drug interactions Drug – Drug

• Sulphonamides may impair bactericidal effects of the drug.

• If used with oral contraceptives, amoxicillin may reduce it’s efficacy.

• Tetracyclines may reduce the bactericidal effects of amoxicillin.

Adverse Effects CNS:anxiety, behavioural changes, confusions, and convulsions.
 GI: black and hairy tongue,toothe discoloration, vomiting

Dermatologic: rashes, urticaria

1. Determine previous hypersensitivity reactions to penicillins, cephalosporins, and other allergens

Nursing prior to therapy.

Responsibilites 2. Lab tests: Baseline C&S tests prior to initiation of therapy, start drug pending results; periodic

assessments of renal, hepatic, and hematologic functions should be made during prolonged

therapy.

3. Monitor for S&S of an urticarial rash (usually occurring within a few days after start of drug)

suggestive of a hypersensitivity reaction. If it occurs, look for other signs of hypersensitivity

(fever, wheezing, generalized itching, dyspnea), and report to physician immediately.

4. Report onset of generalized, erythematous, maculopapular rash (ampicillin rash) to physician.

Ampicillin rash is not due to hypersensitivity; however, hypersensitivity should be ruled out.

5. Closely monitor diarrhea to rule out pseudomembranous colitis.

5. Take drug around the clock, do not miss a dose, and continue therapy until all medication is

taken, unless otherwise directed by physician.

6. Report onset of diarrhea and other possible symptoms of superinfection to physician