Professional Documents
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EXO
Shiga Toxin Protein Syn Inhibitor (PsI) @ 60S
Diptheria, Psudomona EF2 is ADP-r -> PsI
Vibrio c. (A-B toxin), V.p and V.v cAMP by ADP-r
ENDO
N. meningitides PLS-> CD14-> macrophage, NO-> shock
Sq Sm CC Central
Adenocarcinoma Peripheral
a) 69XXY
b) partial mole
c) Echinococcosis
d) DIC
e) 46XY
f) placenta previa
2) 12 yr old girl presents to clinic with stage 4 Tanner development of the breast. Increased levels of Inhibin are seen on BT, if
untreated it is expected to progress to Endometrial Hyperplasia. Estrogen secretion is elevated, as well as pathogenic Eosinophilic
secretions.
a) 21 –hydroxylase deficiency
b) pituitary tumor
c) hyperprolactinemia
d) granulose cell tumor
e) adrenal adenoma
HEMATOLOGY/ONCOLOGY
3) Chronic Alcoholic Pt comes to ER complaining of sudden onset of dyspnea, chest pain and is coughing large amounts of dark
blood after a lengthy car trip. Osculation reveals a friction rub. Blood tests will reveal?
a) increased AST
b) increased bleeding time
c) d-dimers
d) increased erythropoietin
4) A diabetic pt complaining of sever and reoccurring abdominal pain is presented to the psychiatric ward with paranoia,
anxiety and family confirmed depression and occasional seizures. Past medical history is consistent for Phenobarbital, Clozapine,
Metforman, Acarbose. What drug is contributing to the psychiatric symptoms and abdominal pain and why?
50 An elderly pt presents with swollen gums, easy bruising. It is found that her diet consists mainly of toast and sugar filled
juice. What would the blood hemostasis show?
6) 35 yr old Male complains of erectile dysfunction and gynocomastia. Alcohol consumption is extremely high. Examination
shows no dysfunction to seminiferous tubules. Identify the correct hormone levels?
7) 54 year old woman presents to ER with amenorrhea, hot flushes and night sweats. Physical exam reveals clitoromegaly and
excess pubic hair. Lab findings show increased Testosterone and Estrogen. What is the dx.
a) Menopause
b) Exogenous Estrogen from OCP
c) Poly Ovarian Syndrome, LH:FSH ratio >2
d) Secondary Amenorrhea
8) 13 year old pt comes to ER presenting chronic weakness and hypotention and hyperpigmentation. Lab results revile
increased ACTH, eosinophilia, lymphocytosis and neutropenia. Physical exam reveals enlarged liver. What is the cause of the
disorder?
a) Neisseria Meningitidis
b) M. pneumonia
c) S. Areus
d) Miliary TB
9) Pt presents to ER with painful rash in mouth and on skin. Tests reveal immunoflorescence throughout epidermis. What is
the explination?
10) Pt is presented to the ER after a car crash. Xray shows hemisection of the spinal cord at L2. What will the pt present with?
a) Ipsilateral UMN signs L2 and below, Ipsilateral loss of tactile stimulation and proprioception L2 and below, Ipsilateral loss of
sensation at L2, Contralateral pain and temp loss at L2 and below.
b) Hornors Syndrome
c) Ipsilateral UMN signs L3 and below, Ipsilateral loss of tactile stimulation and proprioception L3 and below, Ipsilateral loss of
sensation at L2, Contralateral pain and temp loss at L3 and below.
d) Ipsilateral UMN signs L3 and below, Ipsilateral loss of tactile stimulation and proprioception L3 and below, Ipsilateral loss of
sensation at L2, ipsilateral pain and temp loss at L3 and below.
11) Pt presents with increased weight gain, moon face, hyperinsulinemia. What additional findings will be present?
a) pheochromocytoma
b) hypophsphate
c) osteoporosis
d) legg-calve-perthes disease
e) osteomylitis
12) Pregnant woman with hypertention. What is the MOA given the most appropriate aanti-hypertensive?
13) Pt is being examined for visual function. The Dr shines a light in the right eye of the pt and sees constriction of the pupil he
notices that the left pupil does not respond at the same time. What nerve and nucleolus is damaged.
14) Pt is being examined for Corneal Reflex with a cotton swab. The Dr touches the left eye of the pt and the pt blinks. Given
that the right eye should also blink through efferent stimulation what could the pt also be suffering from?
a) Sjögren's syndrome
b) mastication
c) lock jaw
d) hperacusis
e) tinnitus
15) Predict the phenotype of a lacZ mutant, which has a mutation in the gene for β-galactosidase.
1) Why do drugs such as Penicillin, Rifampin, Sulfas, NSAIDs and Diuretics -> Interstitial Nephritis
a) hypersensitivity
b) allergic
c) drug concentration toxicity
d) urine retention
a) decreased protein
b) osmotic change
c) low urine outflow
d) blocked tubules
a) increased metabolism
b) increased T-cell proliferation
c) increased gluconeogenisis
d) increased bone formation
e) decreased urine
4) Individual flies to the alps from sea level. What is the physiological body compensation?
a) Mitochondrial toxin to the outer matrix decreasing protons inside the matrix
b) Coupling of Oxidative phosphorylation
c) Mitochondrial toxin to the inner matrix increasing protons inside the matrix
d) Vasoconstriction of peripheral artieries
9) A 12 yr old boy presents with fever, malaise, hypertension and smoky urine. He did have an upper throat infection about 2
days ago. On physical exam, his vitals are normal.
DDx:
a) Berger, hematuria, URI, children more common
c) Goodpastures, age 20-40 more common, pulmonary hemoptysis
d) BUN, brown urine casts (ischemic, dehydration, shock)
e) drug induced (penicillin, cephalexin, NSAID, anti-freeze)
f) HCV, GI, Palpable Purpura, Raynauds
g) joint pain, child, PP of bum and lower extremities
10) Pt becomes sick after being out for a sushi dinner, lab shows No bacteria in culture.
What is the mechanism of action?
11) From Q 10 above, What is the bacteria that caused the sickness?
a) V. cholerae
b) V. parahemolyticus
c) V. vulnificus
d) C. diphtheria
a) CMV
b) VZV
c) H esophagitis
d) oral thrush
13) See a AD pedigree with skip generations. What is the reason for the skiped den?
a) non disjuction
b) random
c) somatic mosaicism
d) gonadal mosaicism
14) Child presents with diarrhea and convulsions. On physical exam it is noted that his nails have transverse lines or bands of
blood across. What would the ingested substance affect.
a) RAA
b) liver parenchyma
c) Cytochrome IV ofETC
d) OOA in gluconeogenisis
30) Child w/ numerous bacterial infections, chronic diarrhea and ear infections is brought in for testing. Blood test reveals pro-T
cells however no mature T or B cells. What is the deficient enzyme?
a) adinosine deaminase
b) IL2
c) MHC II
d) IgM
31) Pt returns home after an MI with warfarin, asparin to take. INR is within normal range for the first week and then proceeds
to increase. What could have the pt been adding to his diet in excess to account for the problem?
a) Vitamin A
b) Vitamin C
c) Vitamin K
d) Vitamin E
a) Klinfelters Syndrome
b) Kallman Syndrome
c) Noonans Syndrome
d) Turners Syndrome
33) Pt taking a mesna to counter the actions of a drug she is on for sever rheumatoid arthritis is at risk of developing which of the
following?
34) Pt presents with Magenta tongue (blue red), neovascularization of cornea, angular stomatitis (chilitis). What is the Vitamin
deficiency?
a) pyridoxine B6
b) riboflavin B2
c) pantothenic acid B5
d) V-A
e) biotin B7
35) Person on a camping trip drinks the stream water and becomes tired, dizzy and bluish in color. What is happening
metabolically ?
a) pyridoxine B6
b) pantothenic acid B5
c) methyl blue
d) V-C
e) d & e
37) A company has done a drug survey and they are interested in increasing the probability of a Normal (disease free) test. What
factors need to be in place?
a) glomerulosa
b) facicularis
c) reticularis
d) b, c
a) endotoxins
b) C5a
c) LTB4
d) IL-1
e) TNF
f) lithium
a) skeletal mm cell
b) smooth mm cell
c) cardiac mm cell
d) stem cells
e) intestinal cell
a) prostate cancer
b) potts syndrome
c) batson venous plexus
d) transitional carcinoma of the bladder
44) Pt with CMV has used gancyclovir with minimal results. Given the next drug req. what is the MOA?
45) pt is sensitive to sunlight, with wine-red urine upon voiding what is the defect?
46) pt has intermittent nuerological dysfunction, psychosis, and abdominal pain. What is the defective enzyme?
47) 35yr old male with chronic lower back pain radiating to other spinal areas as well as fatigue. The pt also complains of
floaters in the eye along with an aversion to bright light. What is the diagnosis?
a) anemia
b) osteoporosis
c) ankylosing spondylitis
d) SLE
48) Given the above pt, what is a common cause of the disease?
a) klebsiella
b) E.coli
c) S. pneumonia
d) N. meningititis
a) short QT interval
b) long QT interval
c) T wave
d) U wave
50) Pt has neck vein distention when breathing in (Kussmauls sign), radial pulse is decreased (pulsus paradoxus). On
auscultation there is MUFFLED heart sounds. What is the problem with the heart?
a) Congestive Cardiomyopathy
b) Hypertrophic cardiomyopathy
c) Constrictive Pericarditis
d) Tuberous sclerosis
51) In above question, what is the dx if the pt has a diastolic KNOCK on auscultation?
a) Congestive Cardiomyopathy
b) Hypertrophic cardiomyopathy
c) Constrictive Pericarditis
d) Tuberous sclerosis