Date of lecture: January 25, 2011 Transcriptionist: TransMistress Razeille IV-2
Definition of Outbreak • Probable
• Occurrence of more cases of disease than expected in – Patient older than 5 years with severe a given area among a specific group of people over a dehydration or dying of acute watery particular period of time diarrhea in town “x” between 1 June and • Two or more linked cases of the same illness 20 July 2006 • Confirmed Objectives of Outbreak Investigations – Isolation of Vibrio cholerae from stool of • To determine the cause of the outbreak patient • To control ongoing outbreaks • To prevent future outbreaks Control the Source of Pathogen • To provide statutorily mandated services • Remove source of contamination • To strengthen surveillance at local level • Remove persons from exposure • To advance knowledge about a disease • Inactivate / neutralize the pathogen • To provide training opportunities • Isolate and/or treat infected persons
Specific Demands when Investigating Outbreaks Interrupt Transmission
• Unexpected event • Interrupt environmental sources • Need to act quickly • Control vector transmission • Need for rapid control • Improve personal hygiene • Work carried out in the field Modify Host Response Steps of an Outbreak Investigation • Immunize susceptibles • Confirm outbreak and diagnosis • Use prophylactic chemotherapy Case definition and identification Descriptive data collection and analysis At the End Develop hypothesis • Prepare written report Analytical studies to test hypotheses • Communicate public health messages • Special studies • Influence public health policy • Implementation of control measures • Evaluate performance Communication, including outbreak report Cessation of an outbreak occurs when there is: Case Definition • Standard set of criteria for deciding if a person should - elimination of source of contamination be classified as suffering from the disease under - interruption of transmission investigation. - reduction/exhaustion of susceptibles • Clinical criteria, restrictions of time, place, person - modification of the effect of primary pathogen • Simple, practical, objective • Sensitivity versus specificity An investigator should have knowledge on the following: Ex. • various types of etiologic agents and the resultant Patient older than 5 years with severe dehydration or dying of disease acute watery diarrhea in town “X” between 1 June and 20 July • epidemiological characteristics of outbreaks 2006 associated with different etiologic agents of resultant diseases Examples of Case Definition: • clinical symptoms of resultant diseases • Possible • environmental and food sanitation practices – Patient with severe diarrhea • sources of exposure which are vulnerable to contamination with an infectious or chemical agent • laboratory test available to determine causative agents • read/search for additional data on studies, prevention and control