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>    Is readily absorbed from the GIT and peak plasma >Treatment of >Rifampicin: Patients >careful
Brand Name: concentrations of about 7-10 mcg/mL have been reported 2-4 hrs after pulmonary & w/ jaundice. monitoring of
FIXCOM a dose of 600 mg, although there may be considerable interindividual extra-pulmonary >Pyrazinamide: Liver hepatic function.
Generic Name: variation. Food may reduce and delay absorption. Rifampicin is TB. damage, acute gout or
Rifampicin approximately 80% bound to plasma proteins. It is widely distributed hyperuricemia. >check hepatic
150mg in body tissues and fluids and diffusion into the CSF is increased when >Ethambutol: Optic function before
the meninges are inflamed. neuritis. and during
Isoniazid treatment.
75mg >   Is readily absorbed from the GIT. Peak concentrations of
about 3-8 mcg/mL appear in blood 1-2 hrs after a fasting dose of 300 >monitor liver
mg by mouth. The rate and extent of absorption of isoniazid is reduced function and
Pyrazinamide by food. Isoniazid is not considered to be bound appreciably to plasma serum uric acid
400mg proteins and diffuses into all body tissues and fluids, including the regularly.
CSF. The plasma half-life for isoniazid ranges from about 1-6 hrs,
Ethambutol those who are fast acetylators having shorter half-lives. >caution when
275mg assessing visual
>     Is readily absorbed from the GIT. Peak serum acuity in patients
concentrations occur about 2 hrs after a dose by mouth and have been with cataracts to
reported to be about 35 mcg/mL after 1.5 g and 66 mcg/mL after 3 g. make sure that
Pyrazinamide is widely distributed in the body fluids and tissues and changes are not
diffuses into the CSF. The half-life has been reported to be about 9-10 due to the
hrs. It is metabolized primarily in the liver by hydrolysis to the major underlying causes
active metabolite pyrazinoic acid which is subsequently hydroxylated .
to the major excretory product 5-hydroxypyrazinoic acid.

>    Is distributed to most tissues, including the lungs,


kidneys and erythrocytes. It diffuses into the CSF when the meninges
are inflamed. It has been reported to cross the placenta and is
distributed into breast milk. The elimination half-life following oral
administration is about 3-4 hrs.
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> inhibits synthesis of >it is effective for the >hypersensitivity to >determine history of
Brand Name: bacterial cell wall, treatment of penicillinase. cephalosporins and related hypersensitivity
Ceftin causing cell death. antibiotics, pregnancy reactions to
>effectively treats bone lactation. cephalosporins,
Generic Name: and joint infections, penicillins and history
Cefuroxime bronchitis, meningitis, >can cause diarrhea, of allergies,
gonorrhea, otitis media, nausea, vomiting, particularly to drugs
Classes: pharyngitis, lower headache, migraine and before therapy is
Antibiotic respiratory tract abdominal pain if tolerated. initiated.
infections, skin and soft
250 mg BID tissue infections, urinary >inspect IM and IV
tract infections and is used injection sites
for surgical prophylaxis or frequently for signs of
eliminating infections. phlebitis.

>report onset of loose


stools or diarrhea.

>monitor I&O rates


and pattern; especially
important in severely
ill patients receiving
high doses. Report any
significant changes.


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Brand name: Anti-inflammatory, Relief of mild to moderate Contraindicated with allergy to Administer drug with
Motrin analgesic, and antipyretic pain ibuprofen, salicylates, or other food or after meals if GI
activities largely related to NSAIDs upset occurs.
Generic name: inhibition of prostaglandin >Fever reduction
Ibuprofen synthesis; exact >Use cautiously with CV >Avoid OTC drugs. Many
mechanisms of action are >Prevention and treatment of dysfunction, for impaired renal of these drugs contain
Classes: not known. migraine headache function similar medication, and
serious overdosage can
Inhibits both occur.
5-10mg/kg PO every 6-8 cyclooxygenase(COX) 1
hours; do not exceed 40 and 2. >You may experience
mg/kg/day these side effects:
Constipation, Nausea, GI
upset, dizziness

>Report fever, rash,


itching, weight gain,
swelling in fingers or
ankles, changes in vision,
black or tarry stools

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