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INTRODUCTION:
Abstract:
Nanotechnology is being applied to cancer in two broad
In this new era , technology is playing important role in
areas: the development of nanovectors, such as nanoparticles,
overall development of human being .One such
which can be loaded with drugs or imaging agents and then
technology is nano technology which has its own impact
targeted to tumours, and high-throughput nanosensor devices
in treating dreadful diseases such as cancer. Our paper
for detecting the biological signatures of cancer. Combined,
shows how nano technology could form the basis of an
such technologies could lead to earlier diagnosis and better
inexpensive and non-invasive diagnostic tool for cancer. It
treatment for patients with cancer.
is here that nanotechnology can play a pivotal role,
providing the technological power and tools that will
Nanotechnology has been used to create new and improved
enable those developing new diagnostics, therapeutics,
imaging techniques to find small tumors. Researchers have
and preventives to keep pace with today’s explosion in
shown that incredibly small iron oxide particles
knowledge. The concept of nanoscale devices has led to
(nanoparticulates) can be used with magnetic resonance
the development of biodegradable self-assembled
imaging (MRI) to accurately detect cancers that have spread
nanoparticles, which are being engineered for the
to lymph nodes, without requiring surgery. Through the
targeted delivery of anticancer drugs and imaging
concerted development of nanoscale devices or devices with
contrast agents.
nanoscale materials and components, the NCI Alliance for
Nanotechnology in Cancer will facilitate their integration
Nanotechnology provides the sized materials that can be
within the existing cancer research infrastructure. The
synthesized and function in the same general size range
Alliance will bring enabling technologies for:
and Biologic structures. Attempts are made to develop
forms of anticancer therapeutics based on nanomaterials. Novel methods to manage the symptoms of cancer
Dendritic polymer nanodevices serves as a means for the that adversely impact quality of life .
detection of cancer cells, the identification of cancer
signatures, and the targeted delivery of anti-cancer Research tools that will enable rapid identification
therapeutics (cis-platin, taxol) and contrast agents to of new targets for clinical development and predict
The body is made up of many types of cells. These cells grow treatment for cancer, and patients often receive a combination
and divide in a controlled way to produce more cells as they of therapies and palliative care. Treatments usually fall into
are needed to keep the body healthy. When cells become old one of the following categories: surgery, radiation,
or damaged, they die and are replaced with new cells. chemotherapy, immunotherapy, hormone therapy, or gene
therapy.
However, sometimes this orderly process goes wrong. The
genetic material (DNA) of a cell can become damaged or Surgery
changed, producing mutations that affect normal cell growth
and division. When this happens, cells do not die when they Surgery is the oldest known treatment for cancer. If a cancer
should and new cells form when the body does not need has not metastasized, it is possible to completely cure a
them. The extra cells may form a mass of tissue called a patient by surgically removing the cancer from the body.
effects because the energy beams would damage normal, thousand times smaller than human cells. They are similar in
healthy tissue, but technologies have improved so that beams size to large biological molecules ("biomolecules") such as
can be more accurately targeted. Radiotherapy is used as a enzymes and receptors. As an example, hemoglobin, the
standalone treatment to shrink a tumor or destroy cancer cells molecule that carries oxygen in red blood cells, is
(including those associated with leukemia and lymphoma), approximately 5 nanometers in diameter. Nanoscale devices
and it is also used in combination with other cancer smaller than 50 nanometers can easily enter most cells, while
The goal of gene therapy is to replace damaged genes with interact with biomolecules on both the surface of cells and
ones that work to address a root cause of cancer: damage to inside of cells. By gaining access to so many areas of the
DNA. For example, researchers are trying to replace the body, biological they have the potential to detect disease and
damaged gene that signals cells to stop dividing with a copy deliver treatment in ways unimagined before now. And since
of a working gene. Other gene-based therapies focus on processes, including events that lead to cancer, occur at the
further damaging cancer cell DNA to the point where the cell nanoscale at and inside cells, nanotechnology offers a wealth
commits suicide. Gene therapy is a very young field and has of tools that are providing cancer researchers with new and
not yet resulted in any successful treatments. innovative ways to diagnose and treat cancer.
Nanodevices Are Small Enough to Enter Cells :
Recent Researches:
Where do they go?
In their latest paper the researchers have gone a step further, Nanotechnology has already demonstrated promising results
using a clever technique to investigate how the nanoparticles in cancer research and treatment. A release from NCI notes
target their deadly payload to cancers that have spread around some recent advances in cancer treatment involving
To do this, the scientists injected nanoparticles carrying a so- Recent researches neatly prove that – in principle at least – it
called “reporter” gene into mice with cancer that had spread, is possible to deliver gene therapy to tumours throughout the
allowing them to track where the particles ended up. body, and ‘see’ it at work. Future treatments based on this
Specifically, they used a gene carrying instructions for a technology would ideally use nanoparticles that combined a
protein that pumps the chemical iodine into cells. tumour-killing gene with the iodine reporter gene.
The idea is that the cancer cells take up the nanoparticles, and The latest research is the result of ongoing
start producing the iodine-pumping protein. Then the collaborative work between the Prostate Cancer
scientists give tiny, harmless doses of radioactive iodine to Research and Educational Foundation (PC-REF)
the mice, which get taken up by only those cancer cells and Baltimore-based MedInsight Research Institute.
where the iodine-shuttling gene has been activated. Finally, Their previous work has shown that noscapine has
using CT scanning (which detects radioactive molecules), it’s properties that limit the growth of prostate cancer.
possible to build up an impressively detailed picture of the The latest study was based on the theory that
location of the tumours throughout the bodies of the mice. prostate cancer could be a suitable target for a risk-
reduction approach because of its high prevalence
and significant morbidity and mortality.
Noscapine has been used worldwide since the 1950s
as an ingredient in over-the-counter cough
medicines and was originally suggested as an anti-
cancer agent in the early
1960s. But major studies of its anti-cancer properties
have only taken place in recent years.
Nanoscale drug delivery devices are being
developed to deliver anticancer therapeutics
specifically to tumors. Liposomes are one such "first
generation" nanoscale device. Liposomal
doxorubicin is used to treat specific forms of cancer,
while liposomal amphotericin B treats fungal Today drug delivery technologies are patent protected
infections often associated with aggressive formulation technologies that modify drug release profile,
anticancer treatment. Recently, a nanoparticulate absorption, distribution and elimination for the benefit of
formulation of the well-known anticancer compound improving product efficacy and safety, as well as patient
taxol was submitted as a new treatment for advanced convenience and compliance.
stage breast cancer. Many medications such as peptide and protein, antibody,
vaccine and gene based drugs, in general may not be
Nanomedical capsule in cancer treatment: delivered using these routes because they might be
susceptible to enzymatic degradation or can not be absorbed
Nanobotmodels Company creates model of à drug into the systemic circulation efficiently due to molecular size
delivery nanocapsule, which can be used to cancer and charge issues to be therapeutically effective. For this
treatment. Nanotechnology and nanorobotics reason many protein and peptide drugs have to be delivered
development can boost and radically change modern by injection. For example, many immunizations are based on
drug delivery methods. This is our vision of cancer- the delivery of protein drugs and are often done by injection.
treatment in the next decade.
Targeted drug delivery is a method of delivering medication
to a patient in a manner that increases the concentration of
the medication in some parts of the body relative to others.
Conclusion
www.cancer .gov
[3] www.howstuffworks.com.
[4].www.thinkdigit.com.