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    The document categorizes indications for plasmapheresis and cytapheresis according to the American Society for Apheresis. Category I includes standard indications with evidence of efficacy. Category II includes indications where plasmapheresis may be an acceptable adjunctive therapy. Category III includes inconclusive evidence of efficacy or uncertain risk-benefit. Category IV includes indications where controlled trials found no efficacy.

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    The document categorizes indications for plasmapheresis and cytapheresis according to the American Society for Apheresis. Category I includes standard indications with evidence of efficacy. Category II includes indications where plasmapheresis may be an acceptable adjunctive therapy. Category III includes inconclusive evidence of efficacy or uncertain risk-benefit. Category IV includes indications where controlled trials found no efficacy.

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    74 views2 pages

    Plasmapheresis

    Uploaded by

    pathoTM
    The document categorizes indications for plasmapheresis and cytapheresis according to the American Society for Apheresis. Category I includes standard indications with evidence of efficacy. Category II includes indications where plasmapheresis may be an acceptable adjunctive therapy. Category III includes inconclusive evidence of efficacy or uncertain risk-benefit. Category IV includes indications where controlled trials found no efficacy.

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    of 2

    THE SECTION Hematology and Oncology

    MERCK MANUALS FOR HEALTHCARE


    SUBJECT Transfusion Medicine
    TOPIC Therapeutic Hemapheresis
    ONLINE MEDICAL LIBRARY PROFESSIONALS

    INDICATIONS FOR PLASMAPHERESIS


    ACCORDING TO THE AMERICAN SOCIETY FOR APHERESIS
    CATEGORY PLASMAPHERESIS CYTAPHERESIS
    I. Standard and Acute inflammatory demyelinating Cutaneous Tcell lymphoma:
    acceptable polyradiculoneuropathy photopheresis
    under certain Antiglomerular basement membrane Erythrocytosis/polycythemia
    circumstances, antibody disease vera
    including pri Chronic inflammatory demyelinating Familial hypercholesterolemia:
    mary therapy polyradiculoneuropathy lipid adsorption
    Demyelinating polyneuropathy with Leukocytosis syndrome:
    IgG/IgA leukodepletion
    Myasthenia gravis Sickle cell diseases: red cell
    Phytanic acid storage disease exchange
    Posttransfusion purpura Thrombocytosis: platelet
    Thrombotic thrombocytopenia purpura depletion
    II. Sufficient evi ABO incompatible marrow transplant Chronic graft vs host disease:
    dence to sug (recipient) photopheresis
    gest efficacy; Acute CNS inflammatory demyelinat Erythrocytosis/polycythemia
    acceptable ing disease vera: RBC depletion
    therapy on an Coagulation factor inhibitors Hyperparasitemia—Malaria/
    adjunctive Cryoglobulinemia babesiosis: RBC exchange
    basis Cryoglobulinemia with polyneurop Idiopathic thrombocytopenic
    athy purpura: immunoadsorption
    Familial hypercholesterolemia RA: immunoadsorption
    LambertEaton syndrome
    Myeloma/acute renal failure
    Myeloma/paraproteins/hyperviscosity
    PANDAS (pediatric autoimmune
    neuropsychiatric disorders associated
    with streptococcal infections)
    Polyneuropathy with IgM
    (± Waldenström’s)
    Rapidly progressive glomerulonephritis
    Sydenham’s chorea
    III. Inconclusive Acute hepatic failure Cutaneous Tcell lymphoma:
    evidence for Aplastic anemia/pure RBC aplasia leukodepletion
    efficacy or Autoimmune hemolytic anemia Demyelinating polyneuropa
    uncertain Heart transplant rejection thy with IgG/IgA: immu
    benefitrisk Hemolytic disease of the newborn noadsorption
    ratio Hemolytic uremic syndrome Heart transplant rejection:
    Inclusionbody myositis photopheresis
    Multiple myeloma with polyneuropathy Multiple sclerosis, progres
    Multiple sclerosis (progressive) sive: lymphocytapheresis
    Multiple sclerosis (relapsing) Paraneoplastic neurologic syn
    Overdose poisoning dromes: immunoadsorption
    Platelet alloimmunization and refrac Platelet alloimmunization and
    toriness refractoriness: immunoad
    Paraneoplastic neurologic syndromes sorption
    POEMS (plasma cell dyscrasia with Polyneuropathy with IgM
    polyneuropathy, organomegaly, (± Waldenström’s): immu
    endocrinopathy, monoclonal protein, noadsorption
    and skin changes) syndrome
    Polymyositis or dermatomyositis
    Rasmussen’s encephalitis
    Raynaud’s phenomenon
    Recurrent focal glomerulosclerosis
    Renal transplantation (presensitization)
    THE SECTION Hematology and Oncology

    MERCK MANUALS FOR HEALTHCARE


    SUBJECT Transfusion Medicine
    TOPIC Therapeutic Hemapheresis
    ONLINE MEDICAL LIBRARY PROFESSIONALS

    INDICATIONS FOR PLASMAPHERESIS


    ACCORDING TO THE AMERICAN SOCIETY FOR APHERESIS—Continued
    CATEGORY PLASMAPHERESIS CYTAPHERESIS
    Scleroderma/progressive systemic
    sclerosis
    SLE
    Stiff-man syndrome
    Vasculitis
    IV. Lack of effi- Renal transplantation rejection Inclusion-body myositis:
    cacy in con- RA leukapheresis
    trolled trials Systemic (AL) amyloidosis Polymyositis or dermatomyo-
    sitis

    Data from McLeod BC. Introduction to the third special issue: Clinical applications of therapeutic
    apheresis. Journal of Clinical Apheresis 15:1–5, 2000.

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