As Chairman and CEO of Unicity International, the Bios Life Company, I am

delighted you are researching our company and our business opportunity. Bios
Life gives you and your patients a safe and natural treatment option for obesity,
diabetes, and cardiovascular disease that you will not find anywhere else. You
can incorporate it into your office practice, or conduct it as a separate home
based business.

At Unicity we are well aware of the importance of having excellent clinical trials
based on sound research protocols for any product recommendations that you
might offer to your patients. I am confident you will find the research that stands
behind our Bios Life products quite compelling.

I look forward to you joining the thousands of medical professionals

recommending our products that are making life better for hundreds of thousands
of people around the world.

Best Regards,

Stewart F. Hughes
Chairman and CEO

www.unicity.net 1201 North 800 East Orem, Utah 84097 P: 801.226.2600 F: 801.714.1100
 BIOS LIFE SLIM Product Information Summary
AMOUNT MECHANISM
INGREDIENTS NUTRIENTS PER SERVING OF ACTION
Guar Gum
Biosphere Gum Arabic
4 grams A patented blend of 5 highly soluble fibers
combined with mineral carbonate that quickly
forms a fiber matrix in the digestive tract.
Fiber™ Locust Bean -Reduces appetite and absorption of fat
-Glucose is moderated by delayed absorption
Citrus Pectin
and decreased glycemic index of
Oat Fiber carbohydrates allowing for fat burning.
Maltodextrin -Bile acid is sequestered and decreases
cholesterol levels.
Beta Glucans -Beta Glucans are a key factor in immune health.
Helps restore the brains sensitivity to Leptin*
Unicity 7X™ Proprietary blend of plant
derived polysaccharides
This decreases appetite and cravings and
increases metabolism which is key to FAT LOSS

Flavor - Orange juice powder *Leptin is a hormone produced by fat cells which
with Citric acid and sucralose helps regulate appetite and metabolism.

Bios Cardio On average lowers LDL 31%, raises HDL 29% and
lowers triglycerides 40%.

Matrix™ Lowering LDL facilitates fat burning.

Soy Bean Extract 1 gram per serving* Blocks food-based cholesterol from being
Phytosterols Sunflower Extract
absorbed into the bloodstream by blocking the
cholesterol transport mechanisms in the
intestinal tract.

*Foods containing at least .65g per dose of

phytosterols (plant sterol esters), taken twice a day
with meals for a total daily intake of 1.3g may reduce
the risk of heart disease associated with high
cholesterol levels and are recommended by the
NCEP guidelines
Sugar Cane Extract 6 mg Lowers LDL by inhibiting HMG-CoA reductase
Policosanol without the unwanted side effects of
statin medications.
Reduces LDL oxidation and platelet aggregation.

Chrysanthemum Chrysanthemum Extract 12.5 mg Activates an enzyme called 7-alpha hydroxylase

that removes LDL cholesterol and converts it

Morifolium into bile acids.

Beta Carotene 750 IU 15% Antioxidants that help prevent Lipid and LDL
Bios Vitamin Vitamin C (ascorbic acid) 45 mg 75%
oxidation and strengthen the immune system

Complex™ Vitamin E (d-alpha-tocopheryl) 20 IU 67%

Chromium polynicotinate 100 mcg 84% Enhances effectiveness of insulin--reduces
blood glucose levels
Calcium Carbonate 60 mg 6% Provides for gel like matrix formation in the
digestive tract which delays absorption of
food, especially carbohydrates.
Vitamin B complex Powerful B complex that helps breakdown
nutrients into energy.
B1 Thiamin 2 mg 134%
B2 Riboflavin 2 mg 118%
B3 Niacin 26 mcg 130%
B6 Pyridoxine 7 mg 350%
B7 Biotin 20 mcg 7% Biotin helps metabolism and use of free
fatty acids for energy
B9 Folate 220 mcg 55%
B12 Cyanocobolamin 25 mcg 417%
Zinc Gluconate 2.33 mg 16% Essential for cellular health
Selenium 3 mcg 5% May inhibit LDL oxidation
 How Bios Life™ Complete Can Lower Your Cholesterol and Add Years to Your Life
The High Cholesterol/Cardiovascular Disease Connection U.S. Leading Causes of Death, 2003

One of the most simple and effective ways to determine the general health 1,500,000
Since the early 20th century,

Alzheimer’s Disease
Cardiovascular Disease
of your cardiovascular system is to have your cholesterol level checked on a 1,200,000 Cardiovascular Disease has been
regular basis. Why is this important? Because health officials estimate that 900,000
the leading cause of death and

Accidents
claims more lives each year than
roughly 50 percent of all adults have unhealthy levels of cholesterol and 42 600,000 the next three leading causes of

Cancer
million adults have dangerously high levels—and you could be one of them death combined.
300,000
without even knowing. Lower your cholesterol level, and you’ll lower your risk 0
of cardiovascular disease. American Heart Association: Heart Disease and Stroke Statistics, 2006 Update.

Bios Life Complete™ Lowers High Cholesterol Levels 4 Different Ways — Naturally!
Bios Life Complete is the only supplement that combines all four of the known approaches to lowering harmful cholesterol. This proprietary comprehensive
approach:

1 Helps to Block Re-absorption of Cholesterol in the Intestinal Tract

As food enters the intestinal tract, bile acids are needed to break down fat. The liver uses the cholesterol that’s already
in the body to produce these bile acids. As Bios Life Complete enters the intestinal tract, the proprietary fiber matrix
forms a gel which traps the bile acids (thus, trapping the cholesterol) making them unavailable for re-absorption into
the body. This reduces the overall amount of cholesterol in the body. With this approach alone, Bios Life2 has helped
millions of people worldwide to lower their cholesterol. 4

2 Helps to Block Absorption of Cholesterol Which Comes Directly From Food

Phytosterols have a chemical structure similar to that of cholesterol. However, unlike cholesterol derived from animal
sources—which absorbs easily and raises the body’s own cholesterol levels—phytosterols are present only at very low 1
3 2

levels in the body because they are difficult to absorb.

In fact, phytosterols so closely resemble cholesterol that they can actually block food-based cholesterol from being
absorbed into the bloodstream by blocking the cholesterol transport mechanisms in the intestinal tract. The result is
that both phytosterols and dietary cholesterol end up excreted in waste matter, which can reduce the overall cholesterol
levels in the body.

Foods containing at least .65g per dose of phytosterols (plant sterol esters), taken twice a day with meals for a total daily intake of 1.3g may reduce
the risk of heart disease associated with high cholesterol levels. A serving of Bios Life Complete contains .67g of phytosterols.

3 Reduces the Cholesterol Produced by the Liver

The liver manufactures cholesterol and secretes it into the blood. An important enzyme in this production process is HMG-CoA reductase. This
enzyme can be blocked by certain chemicals—such as those found in statin drugs. Unlike synthetic statins, Unicity utilizes the most effective natural
component called policosanol, which has the same effect.

4
Enhances Enzymatic Breakdown and Removal of LDL Cholesterol
Chrysanthemum morifolium has been used for centuries by Chinese medicine and has just recently been proven to stimulate the enzymes associated
with cholesterol breakdown. In fact, it was Unicity’s research network that uncovered and developed this proprietary discovery!

Choose Bios Life™ Complete. The only clinically proven, patented, natural
alternative to statin drugs to effectively reduce cholesterol.
 Chapter 13
BIOS LIFE PRODUCT TRAINING
Bios Life® is a series of world-class products
developed to attack the world’s number one health
concern — obesity. Obesity is the leading cause
of increased risks for cardiovascular disease (the
world’s number one killer), and diabetes. Becoming
familiar with the benefits of Bios Life, what it is and
how it works, will help you build a strong customer
base and expand your Bios Life Franchise.
Although some of this information may be technical,
please continue your study and supplement this
guide with available resources.
What is Bios Life®?
Bios Life is a vitamin-rich fiber based supplement.
Not all the products in the Bios Life family are
the same. However, they do share common
ingredients, namely the base of a Biosphere Fiber
and a Bios Vitamin Complex. The differences in the
products are the result of the natural progression
of our learning and research of new ingredients
that improve the effectiveness of the products
in combating health issues. We will refer to the
nutrients in Bios Life Slim™ since it represents the
cutting edge of our research and contains all of the
possible nutrients used in the Bios Life family of
products. Bios Life Slim consists of the Biosphere
Fiber, several proprietary ingredients called Unicity
7X, the Bios Cardio matrix and a Bios Vitamin
Complex. We will discuss what each one of these
elements is and what they do.
Biosphere Fiber
A major part of Bios Life is naturally occurring
fiber. Fiber is a normal plant component. It is an
important part of the skin of an apple, for example,
or the bark of a tree. Fibers are carbohydrates
which are not absorbed into the blood stream. They
can’t be digested because the digestive system
lacks the enzymes to break them down. As a result
fiber moves through the digestive system without
influencing what’s going on inside the body.
©2009 Bios Life Franchise Owners Manual 02/09 13.1
The Role of Fiber
There are two kinds of fiber - soluble and insoluble.
Referring again to the apple, the skin contains
mostly insoluble fiber, whereas the flesh of the
apple contains pectin, a soluble fiber. Whether fiber
is soluble or insoluble determines its biological
effect.
Insoluble fiber is known for its digestive benefits.
It helps to bulk the feces and can serve as food
for friendly bacteria, thereby improving the
immune system. It also “scrubs” out the inside of
the intestinal tract, resulting in a cleansing of the
digestive tract.
Soluble fiber, on the other hand, dissolves in the
stomach and becomes a thick, gel-like substance. It
is the same thing that happens if Bios Life is left to
stand in a glass of water for a period of time, only
much more quickly.
Fiber’s Role In Cholesterol Management
One of the roles that the Biosphere Fiber plays is to
reduce cholesterol through a mechanism called Bile
Acid Sequestration. The function of this mechanism
is to trap and eliminate cholesterol in bile acid. This,
in fact, means that Bios Life is able to trap (sequester)
bile acids in the gastrointestinal tract.
How Does It Work?
Bile acids are molecules that the body produces to
digest fat from the diet. They are made by the liver
using cholesterol as a building block. Once the bile
acids are formed, they are transported to the gall
bladder, where the mixture of acids, cholesterol, and
other molecules are concentrated into bile.
Fat entering the gut triggers the gall bladder to excrete
bile into the GI tract, where it aids in the digestion
of fat. Once the fat is digested, the body efficiently
recycles the bile acids. The bile acids are reabsorbed
into the blood stream and broken down into their
various components so that they can be reused. The
cholesterol that is used for this process originates
from the total amount of cholesterol in the body,
and after re-absorption, the total concentration of
cholesterol in the body stays the same. That explains
why bile-mediated normal fat digestion does not
alter the cholesterol concentration in the system.
When Bios Life Slim™ is consumed prior to a meal,
the fiber from the Biosphere Fiber has time to form
the gel in the GI tract before the food arrives. Once
the fat in the food arrives, the normal digestive
signaling occurs and bile is released into the gut. The
bile acids help to digest the fat. However, instead of
being reabsorbed in the blood stream for breakdown
and later use, the fiber gel traps the bile acids along
with the cholesterol, blocking its re-absorption. The
bile acids no longer return to the blood stream but
are excreted in the feces. The recycling mechanism
is thus interrupted. In order for new bile acid to
be synthesized, cholesterol from the body’s stored
supply will need to be used, thus reducing the total
amount of cholesterol in the body.
Another positive benefit from use of the Biosphere
Fiber is to inhibit the synthesis of new cholesterol.
Fiber is fermented in the colon by bacteria to yield
short-chain fatty acids such as acetates, propionates,
and butyrates. Overall these fatty acids inhibit the
synthesis of cholesterol by the liver.
The cholesterol-lowering effect of fiber is so well
established that the Food and Drug Administration
allows the use of a health claim in relation to the
reduction of the risk of heart disease by a product
if the product contains a meaningful amount of
soluble fiber. This is unique, since the FDA only
allows these kinds of health claims for a limited
number of dietary ingredients.
Fiber has been researched in many clinical trials all
over the world. Unicity performed a clinical trial
with Bios Life® at the prestigious Cleveland Clinic.
This study was published in the journal Metabolism.
The results from the Cleveland Clinic study showed
that the Bios Life fiber matrix was able to reduce
LDL (low-density lipoprotein) or bad cholesterol,
and increase HDL (high-density lipoprotein) or
good cholesterol, by significant amounts. The study
also showed that Bios Life improved two other risk
factors for heart disease: APOB (Apolipoprotein B)
and Homocysteine levels. (Refer to chapter 15 for
more information).
13.2
Fiber’s Role In The Management of Blood Glucose;
Good News for Diabetics and Pre-diabetics
Fiber moderates blood sugar levels. Consuming
fiber will lower blood sugar levels and increase the
amount of time it takes for glucose to be absorbed
in the digestive tract. Glucose is the main source
of energy for the body. When food, comprised of
carbohydrates, is consumed, it is broken down
into glucose, after which the body converts it into
adenosine triphosphate, commonly known as ATP
or energy for the body.
All good things should be consumed in
moderation, and carbohydrates are no exception.
The body has an elaborate signaling system to
ensure that blood sugar levels don’t get too high
or too low. If the blood sugar level rises in the
body, the pancreas, sensing this rise, releases the
hormone insulin. Insulin’s role is to help facilitate
the cells in the body to absorb glucose from the
bloodstream. If the blood sugar levels drop too
low, then the body sends a hunger signal to eat.
Unfortunately the main staples of the traditional
American Diet are processed foods, refined sugar
and flour. A negative result of excess consumption
is that blood sugar levels in the body rise much
faster than if a diet consists of whole grains, fruits,
and vegetables. If repeated frequently enough, a
sudden spike of sugar in the blood will cause the
pancreas to work overtime to produce insulin. An
unintended consequence of the hard work of the
pancreas is overshooting the amount of insulin the
body actually needs. An excess of insulin in the
bloodstream causes the body’s blood sugar levels
to drop rapidly. At that point the body signals to
the brain that it is hungry and needs to eat. This
cycle repeats until the body no longer recognizes
the signaling network and becomes insensitive
to insulin. The pancreas, which is overworked to
begin with, quits producing insulin, and the result
is the disease called diabetes.
The Biosphere Fiber in Bios Life Slim moderates
blood glucose levels through two mechanisms.
The first involves the gel-like matrix the fiber
creates in the gut. This matrix interacts with the
food, delaying its absorption. The matrix drags
the food along, and every so often a bit of the food
escapes and is absorbed in the digestive tract. This
is particularly true for carbohydrates.
©2009 Bios Life Franchise Owners Manual 02/09
By delaying the breakdown of carbohydrates, What is Biosphere Fiber?
blood glucose levels do not reach extreme levels,
Biosphere Fiber contains five different highly
relieving stress on the pancreas and allowing it
soluble fibers: pectin, guar gum, gum acacia, locust
to more accurately produce the correct amount of
bean gum, and oat fiber. Gum is a scientific term
insulin needed to facilitate glucose absorption. In
for soluble fiber. These fiber sources have been
general, the same amount of glucose is absorbed.
specifically selected for their cholesterol lowering
What has changed is the time it takes to absorb it.
potential. What is also singular is that calcium
The second mechanism in which Biosphere Fiber carbonate is added to this fiber mixture. The
moderates blood glucose levels is by changing the calcium carbonate is not there for its nutritional
glycemic index of food. This is tied into the first value but for the gel formation. Upon contact with
mechanism. Some foods generate a high level of the acidic environment of the stomach, the calcium
blood glucose while others elicit a lower level carbonate starts to release carbon dioxide, and this
of blood glucose in the body. The difference is bubbling disperses the fiber quickly through the
generally based on the amount of carbohydrates gastric fluid. The fiber matrix is therefore formed
that a specific food contains and how available quickly and efficiently. The manufacturing process
those carbohydrates are to the body. This effect is and blend of ingredients are trade secrets of Unicity
measured by what is called the glycemic index of International and therefore, proprietary.
foods. The glycemic index describes the glucose
The American Heart Association advises people to
effect a food has within the body. The higher the
consume 25 – 30 grams of fiber per day for proper
glycemic index of a food, the greater the impact
nutrition and to promote heart health. The average
that food will have on glucose values and the rise
person only consumes about 12 grams per day, so
of glucose in the blood.
there is a large gap. A single serving of Bios Life
Remember that the soluble fibers in Biosphere Fiber Slim™ provides 4 grams of fiber. Consuming Bios
will create a gel-like matrix in the gut. When food Life Slim can help fill this gap.
enters the digestive tract, this matrix will begin to
interact with it and will create a coating around
the food. This protects the food from digestive
Unicity 7X
enzymes and will delay the breakdown of the One of the research discoveries found in Bios Life
food into glucose. As with the first mechanism, the Slim is the combination of ingredients in our Unicity
interaction of the gel-matrix with food reduces the 7X. This patent-pending, proprietary blend of
overall level of blood glucose levels and spreads ingredients contains plant-derived polysaccharides,
out glucose absorption over a longer period of citric acid, calcium carbonate, and a pinch of
time. orange flavoring. Unicity 7X represents Unicity’s
most cutting edge research added to the Bios
Past research confirms the results of fiber
Life® family of products. The primary constituent
supplementation on blood glucose levels. The
of Unicity 7X is the proprietary blend of plant-
Unicity Science team has presented multiple
derived polysaccharides. It’s this constituent that
abstracts at scientific conferences with data they have
helps facilitate slimming or fat burning. This blend
collected. This includes conferences conducted by
of plant-derived polysaccharides helps restore the
the American Heart Association and the American
body’s hormonal signaling involved in energy
Diabetes Association. The results show decreases
metabolism. Recent studies have shown that by
in fasting glucose levels but primarily in the post-
consuming these plant-derived polysaccharides,
prandial (after a meal) glucose levels. This resulted
the body is able to restore the brain’s sensitivity to
in an average reduction in A1c values of 0.9%. This
a signal (in this case the hormone leptin) that was
is very similar to the improvement seen by adding
previously turned off or ignored.
a prescription diabetes oral medication. Another
result of the studies was a decrease in triglyceride
levels, a result that is crucial to converting bodies
into fat-burning machines as we will discuss later
in this chapter.

©2009 Bios Life Franchise Owners Manual 02/09 13.3

Bios Cardio Matrix
Another constituent of Bios Life Slim™ is the
Bios Cardio Matrix. This matrix is comprised
of the following ingredients: phytosterols,
policosanol from sugar cane, and an extract from
Chrysathemum morifolium, an herb. This group
of ingredients derives its name from the function
it performs, namely to improve cholesterol levels
thereby reducing the risk of cardiovascular disease.
These ingredients are unique and have different
modes of action, yet they work synergistically to
accomplish their task.
Lowering Cholesterol Through Phytosterols
The Bios Cardio Matrix uses three mechanisms to
improve cholesterol levels. The first mechanism is
to utilize plant phytosterols to prevent the body
from absorbing cholesterol from food. A phytosterol
is a naturally occurring chemical found in plants.
Technically speaking, phytosterols are cholesterol
analogs, which mean they have similar functions
but different origins.
Scientists estimate that 25 percent of the total
cholesterol present in the body is derived from food.
Cholesterol is present in many foods—particularly
fatty foods. Therefore, it makes sense that in
order to lower the total cholesterol, the amount of
cholesterol ingested from food should be reduced.
Meet the Cholesterol Transportation Department
After eating, food eventually arrives in the small
intestine,which is the place in the body where most
food components are absorbed into the blood stream.
The body has special transport systems embedded in
the inner layers of the intestinal tissue that look for
various and specific ingredients found in food. One of
the ingredients this system looks for is cholesterol—
after all, cholesterol is necessary to build new cells,
insulate nerves, and produce hormones.
Channel Proteins—All Brawn, No Brains
This cholesterol transport function is performed
by proteins called channel proteins. Once channel
proteins recognize cholesterol in the gut, the
cholesterol is transported by the channel proteins
across the intestinal barrier where the cholesterol
can be absorbed into the bloodstream. Even though
channel proteins are efficient workers, they can be
fooled into spending their time transporting what
13.4
they “think” is real cholesterol. Meanwhile, the real
cholesterol they should be transporting is passed
through the intestines and out of the body, fooling
these proteins is the job of the phytosterols in the
Bios Cardio Matrix.
How Do Phytosterols Work?
Cholesterol is an important molecule serving as a
vital constituent of cell membranes and a precursor
to various bio-molecules. Phytosterols serve similar
functions in plants.
Cholesterol and phytosterols are so similar that they
only differ in one way on the chemical structure—a
small difference that has large consequences. The
body will not absorb phytosterols as it would
absorb cholesterol.
In fact, phytosterols are so similar to cholesterol that
if they’re present in the gut along with cholesterol,
channel proteins can’t tell the difference between
the two. As a result, some of the phytosterols
are picked up by the channel proteins instead of
cholesterol, which allows the cholesterol to be
passed out of the body and not absorbed into the
bloodstream.
In order to position the phytosterols in the small
intestine before the cholesterol from the food
arrives, we recommend Bios Life Slim be consumed
immediately before or with your meals.
There have been many studies done in relation to
the cholesterol-lowering potential of phytosterols.
Many of these studies were performed by
manufacturers of phytosterol-enriched margarine
spread. Typically the studies show a reduction of
LDL (bad cholesterol) in the 5 to 20 percent range
over periods of eight weeks to one year.
Decrease Cholesterol Manufactured by the Liver
The second mechanism of the Bios Cardio Matrix
utilizes policosanol derived from sugar cane to
naturally decrease the amount of cholesterol
manufactured by the liver.
Cholesterol can be brought to its proper levels using
several different approaches because cholesterol has
many functions in the body. Every function involves
its own biochemical reactions, and each one of those
is, in principle, a target for intervention.
The most common approach used to lower
©2009 Bios Life Franchise Owners Manual 02/09
cholesterol is called HMG-CoA reductase inhibition,
or, in other words, decreasing the amount of
cholesterol manufactured by the liver. This is the
approach that prescription statin medications use.
Cholesterol is synthesized from small building
blocks in the body using a long chain of biochemical
reactions. In total, more than 20 steps are used to
construct the cholesterol molecule. Glucose (sugar)
or palmitate (a fatty acid) can be used as the source
molecule that is used to generate cholesterol. Every
individual building step of the molecule is mediated
by enzymes. These are large protein molecules that
serve to facilitate the biochemical steps.
If the cholesterol synthesis process is compared to
an automobile factory line, the workers and robots
are the enzymes that bring the different building
blocks together. Since the construction line is a linear
process, if only one worker is not working or working
slowly, the whole line decreases in speed. This is the
idea behind HMG-CoA reductase inhibition.
Inhibiting the HMG-CoA Reductase Enzyme
HMG-CoA reductase is one of the enzymes
involved in cholesterol synthesis. This abbreviation
stands for 3-hydroxy-3-methylglutaryl CoEnzyme
A reductase. This enzyme converts HMG-CoA
to mevalonate, which is one of the steps in the
production chain. This enzyme can be inhibited
(slowed down) by many components. The most
well-known of these are the statin molecules.
Statin molecules can slow down HMG-CoA by
binding to it. This binding results in a structural
change of the enzyme so that it is no longer active
in the production chain. Disabling enough of this
enzyme throughout the body will reduce the total
amount of cholesterol produced.
Policosanol Inhibits HMG-CoA Reductase
Naturally
Similar to statin molecules, a specific phytonutrient
called policosanol has been shown to inhibit HMG-
CoA. Scientists have spent years establishing the
cholesterol lowering properties of the policosanol
molecule. This molecule is actually a mixture of
a couple of different alcohol molecules whose
structure is unique in the sense that it also interferes
with the effectiveness of HMG-CoA reductase. It is,
in fact, a natural statin and like a statin medication,
is also highly effective.
©2009 Bios Life Franchise Owners Manual 02/09 13.5
Many studies have been performed with this
molecule in dosages comparable to statin dosages,
from 5 mg to 40 mg per day. LDL is typically
reduced by 20 - 25% in a 12 week period. However,
unlike statin medications, the use of policosanol is
effective without producing unwanted side effects.
If policosanol works identically to statins, why
doesn’t it cause the same potential side effects?
Side effects are not caused by the positive results
that the statins have on the enzyme but rather from
the aftereffects on other body tissues such as the
liver. Consequently, the liver has to filter the statin
molecules once the molecules have finished their
job. Policosanol does not produce these negative
side effects.
Bios Life Slim™ contains 6 mg per serving of pure
policosanol. The benefits of this mechanism do not
rely on taking the product before meals, as stated
with the other mechanisms. Policosanol works
throughout the day because cholesterol synthesis
occurs continuously. Therefore, if Bios Life Slim is
not taken before a meal, it can still be taken after
or at any time during the day, yielding positive
results.
Policosanol has another beneficial side-effect
for the cardiovascular system. Research has
shown that it also reduces LDL-oxidation and
platelet aggregation. LDL can be oxidized by free
radicals, leading to an even greater build-up of
atherosclerosis. Slowing this down obviously has
an extra benefit in addition to the mere lowering
of LDL. Platelet aggregation is the process that
may lead to blood clots, which in turn can reduce
the blood flow in the body. Policosanol will help
the body naturally keep the blood fluid at healthy
levels and reduce the risk of clotting.
Boost the Enzymatic Breakdown and Removal of
Cholesterol
The third mechanism of Bios Cardio Matrix utilizes
a water extract of Chrysanthemum morifolium to
boost the enzymatic breakdown and removal of
cholesterol from the body.
Cholesterol’s Bad Reputation
Cholesterol has had a lot of bad press over the
years. But, the fact is the body needs cholesterol.
1. Cholesterol is a major building block for
many of the hormones in the body. For
 example, both the estrogen and testosterone making it the only supplement available that
hormones begin with cholesterol as a possesses this cholesterol-lowering mechanism.
starting molecule.
Bios Vitamin Complex
2. Another important function of cholesterol
Over the past few years, clinical studies have
is to build and maintain cell membranes.
removed all doubt—Bios Life is perhaps the most
Cholesterol floats in the fatty phospholipids
effective all-natural supplement for improving
that comprise cell walls and maintains the
cholesterol levels, lowering triglyceride and blood
structural integrity of cells.
sugar levels, in the prevention of cardiovascular
3. Cholesterol is a fundamental building block disease, heart disease, and diabetes. For complete
for bile acids. The body needs cholesterol— details regarding these studies, refer to chapter 15
the problem is that too much cholesterol is of this manual.
a health risk.
The Bios Vitamin Complex found in Bios Life
Manufacturing the Chemicals Needed to Survive consists of the following ingredients: calcium
carbonate, vitamin A (beta-carotene),vitamin C
The body is like a high-tech chemical manufacturing
(ascorbic acid), vitamin E (d-alpha-tocopherols),
facility. It is continually building, tearing down,
vitamin B1 (thiamine), vitamin B2 (riboflavin),
eliminating or storing the chemicals it needs in
vitamin B3 (niacin), vitamin B6 (pyridoxine HCl),
order to survive. Bile acid is one of these chemicals
vitamin B12 (cyanocobalamin), biotin, folate,
that the body continually manufactures and then
chromium , selenium, and zinc. Bios Life Slim’s
tears down. Bile acids are biological molecules
primary function isn’t to be a vitamin supplement
used to digest fat from the diet. They are made by
but to help burn fat.
the liver using cholesterol as a building block.
With fat burning as the ultimate goal, we have
One of the bile acids is called cholic acid. The
selected vitamins and minerals that will help
first step the body takes to make cholic acid
achieve this goal. For example Niacin, Riboflavin,
is to convert cholesterol into what’s called
Biotin, Cyanocobalamin, Folic Acid, and Thiamine
7-alpha-hydroxycholesterol. What facilitates
HCl provide a powerful vitamin B complex. These
this transformation is an enzyme called 7-alpha
vitamins are essential for:
hydroxylase.
• The breakdown of carbohydrates into glucose
Now imagine being able to give those
(this provides energy for the body)
7-alphahydroxylase enzymes an energy drink that
makes them work twice as hard. As a result, more • The breakdown of fats and proteins (which aids
cholesterol is taken from the body’s storage and the normal functioning of the nervous system)
converted into cholic acid—thus reducing the total
Another example is the addition of the mineral
amount of cholesterol in the body. That’s exactly
chromium. Chromium is believed to enhance the
what the extract from Chrysanthemum does.
effectiveness of insulin. Supplemental chromium
Meet the Proprietary Discovery reduces blood glucose levels. Many researchers
believe that supplementary chromium could be
The Unicity Research and Development Team
very useful for diabetics, especially those with
discovered that a water extract of Chrysanthemum
Type 2 Diabetes.
morifolium energizes the enzyme 7-alpha
hydroxylase. Chrysanthemum morifolium is not a The vitamins and minerals selected to be part of the
new herbal extract. It has been known for centuries Bios Vitamin Complex all play a synergistic role in
that this flower has healthy benefits when it is helping the body produce energy more efficiently,
consumed as a tea. Particularly in parts of Asia, this protecting the cardiovascular system from
flower tea is consumed for the benefits to the eyes oxidative damage and aids in the management of
and the immune system. In fact, this discovery is blood glucose levels.
the foundation of one of the patents on Bios Life®—

13.6 ©2009 Bios Life Franchise Owners Manual 02/09

How Does Bios Life Slim™ Work?
Now that we have discussed what is in Bios Life
Slim, let’s talk about how these nutrients come
together and work to convert the body from a fat-
storing machine to a fat-burning machine. Bios
Life Slim helps the body burn fat in the following
six processes:
1. Reduces Appetite. Bios Life Slim curbs the
appetite by creating a feeling of satiety or
fullness. Scientists have known for years that
fiber increases satiety or, in other words, fiber
makes you feel fuller quicker. As we have
previously mentioned, the Biosphere Fiber
creates a gel-like matrix in the gut. This gel-
like matrix takes up physical space that would
normally be occupied by food.
2. Blocks the Absorption of Fat. Bios Life Slim
absorbs fat by binding to fatty molecules,
prohibiting the absorption of cholesterol into the
blood stream. This is one of the ways in which
Bios Life Slim is able to lower cholesterol to
healthy levels. By removing fat from our bodies,
we reduce the amount of fat our bodies need to
break down or store.
3. Creates “Fat Burning Zones”. Bios Life Slim
utilizes its fat stores for energy production.
We have dubbed these periods as “fat-burning
zones.” The main reason this occurs is because
Bios Life Slim moderates blood glucose levels.
The Biosphere Fiber in Bios Life Slim helps keep
glucose levels from spiking too high as well as
from dropping too low. This in turn requires less
insulin and helps curb the urge to snack. This
will help curb urges to snack. Once the body
has metabolized insulin, it can utilize its own fat
storage for energy production. This is one of the
steps crucial to converting the body into a fat
burning machine.
4. Reduces Leptin Resistance. Bios Life Slim
reduces leptin resistance. Leptin is the signaling
hormone between fat cells and the brain. The
brain stops craving food when it senses an
adequate amount of leptin. This communication
helps the brain control the appetite by helping
to restore proper hormone signaling to the brain
by reducing insulin levels in the body. When
insulin levels are high, this communication
©2009 Bios Life Franchise Owners Manual 02/09 13.7
blocks the release of leptin from the cells, and
as a result, fat accumulates. Maintaining high
levels of insulin in the body results in a lack of
leptin signaling to the brain which can cause
the brain to “stop hearing” the leptin signal.
This situation is called leptin resistance and is
a significant factor in obesity and weight gain.
Bios Life Slim breaks this cycle by moderating
blood glucose levels which in turn moderate
insulin levels. By taking Bios Life Slim regularly
and lowering the level of insulin in the body,
the leptin signaling between the fat cells and
the brain is reestablished. This may help reduce
cravings and appetite leading to fat burn and
weight loss.
5. Lowers Triglycerides. In relation to number two,
Bios Life Slim lowers blood fat levels, known as
triglycerides. Recent studies have shown how
triglycerides inhibit leptin from crossing the
blood brain barrier, preventing the signal from
ever reaching the brain. By reducing triglyceride
levels, we are removing one obstacle from
allowing leptin to get into the brain. The brain
can’t ever react to the message if the message
is blocked at the door way. Regular use of Bios
Life Slim reduces the triglyceride levels, thus
enabling leptin to cross into the brain.
6. Improve Cholesterol Levels. The final benefit of
Bios Life Slim is its ability to manage lipid profiles
and help bring cholesterol levels to a healthy
range. We have already discussed how efficient
Bios Life Slim is in reducing total cholesterol and
LDL-cholesterol levels. However, we are just
discovering how this is important not only for
cardiovascular health but in fat burning. A recent
study has shown how LDL-cholesterol acts as
a signal from the liver to fat cells, inhibiting
lipolysis (the process of breaking down fats).
By reducing LDL-cholesterol, Bios Life Slim
removes an important obstacle in converting
the body into a fat-burning machine. Regular
consumption of Bios Life Slim will reduce total
cholesterol levels but more importantly, will
reduce LDL-cholesterol levels.
Through the combination and synergy of these six
processes, Bios Life Slim helps the body become a
fat-burning machine. There simply isn’t another
supplement on the market like it.
Accelerate the Fat Loss lunch break. Walking is a great activity that
promotes the use of fat-burning for energy.
A couple of questions undoubtedly asked are, “How
can I accelerate the fat loss process?” or, “What can Bios Life Slim is a singular supplement that is
I do to help Bios Life Slim™, slim me down?” The designed to help burn fat and improve overall
research and development team at Unicity has health. By taking Bios Life Slim with meals, your
done the research for you. By incorporating the body will return to its natural fat-burning mode.
following five steps, you can experience quicker Your next meal and every meal after that will
fat loss for yourself as well as teach others how to be much more enjoyable by knowing that with
accelerate their fat loss: Bios Life Slim you’re improving what may be
the biggest factors in determining how you look,
• Start the day off right by jumpstarting your how you feel, and in determining the quality and
metabolism with a high protein breakfast. length of your life.
Studies have shown that a high protein
breakfast leads to a longer feeling of fullness Unicity is committed to producing high quality
and the consumption of smaller meals products. Time, energy and money are invested to
throughout the day. ensure each and every product is safe, effective and
easy to consume. The Research and Development
• Take Bios Life Slim daily along with three team at Unicity collaborates with various research
healthy, well balanced meals. Research has institutions to insure quality and effectiveness.
shown that people who eat three meals a day The results of these collaborations are available to
are less likely to overeat and keep off long- you and can be accessed in Chapter 15.
term weight.
• Use the 4-4-12 rule to space your meals.
For example, allow (4) four hours between
breakfast and lunch, (4) four hours between
lunch and dinner, and (12) twelve hours
between dinner and breakfast. Give your
body time in between meals to metabolize the
insulin produced as a result of eating. A general
rule of thumb is that on average insulin will
drop to low levels in two hours. Spacing your
meals every four hours ensures that your body
will enter a period where you use fat stores
for energy production previously referred to
as the fat burning zone. The key to entering
the fat-burning zone is to avoid snacking
which will increase glucose levels and insulin
levels to spike. The presence of insulin blocks
the body’s ability to access the fat stores for
energy.
• Decrease the glycemic index of your meals.
Change what you eat by eating more fruits
and vegetables and fewer carbohydrates. If
you are going to eat carbs, eat whole grains
and avoid refined foods.
• Increase your level of activity. Look for ways
to exercise or to simply increase the amount of
walking you do. Use the stairs instead of the
elevator. Walk to work or walk during your

13.8 ©2009 Bios Life Franchise Owners Manual 02/09

3454/UNICITY
Unicity International
THE MAKE LIFE BETTER COMPANY
1201 NORTH 800 EAST
OREM, UT 84097
Direct Inquiries to:
(801) 226-2600
www.unicity.net
science@unicity.net
Products of Unicity International are distributed through
independent distributors.
BIO-C™ OTC
[bı̄ō sē]
DESCRIPTION
Bio-C™ is a vitamin C nutritional supplement.
Bio-C™ is a yellow, water-soluble, crystalline powder
pressed into a tablet. Each Bio-C™ tablet consists of a pro-
prietary blend of ascorbyl palmitate, calcium ascorbate, as-
corbic acid, magnesium ascorbate and 75 mg of citrus biofla-
vonoids. In addition to the active ingredients, each 803 mg
tablets contains dextrose, microcrystalline cellulose, silicon
dioxide, magnesium stearate, and stearic acid.
BENEFITS AND RESEARCH
Vitamin C (ascorbic acid) is a water-soluble vitamin that is
used in the body to form cartilage, collagen, muscles and
blood vessels. Vitamin C is a potent antioxidant that can
protect small molecules such as proteins, carbohydrates,
nucleic acids and lipids from damage caused by free radicals
that are generated through the course of normal metabo-
lism or through exposure to external toxins and pollutants
(e.g. ultraviolet radiation from the sun or smoking). Vitamin
C can also regenerate other antioxidants like vitamin E. Ad-
ditionally, vitamin C is required for the synthesis of carni-
tine, a molecule involved in the transport of fats across the
mitochondrial membrane, as well as the synthesis of norep-
inephrine, a neurotransmitter.*
USAGE
Take one tablet morning and night with a meal.
SAFETY AND WARNINGS
Bio-C™ is well tolerated. Some gastrointestinal discomfort
may be experienced as with any dietary supplement.
HOW SUPPLIED
Available in tablets.
REFERENCES
Carr, AC and Frei B. (1999), American Journal of Clinical
Nutrition 96: 1086-1107.
Jacob, RA and Sotoudeh G. (2002), Nutrition in Clinical
Care 5: 66-74.
Deruelle F, Baron B. (2008), Journal of Alternative and
Complementary Medicine 14:1291-1298.
Levine M, Rumsey SC, Daruwala R, Park JB, Wang Y.
(1999), The Journal of the American Medical Association
281: 1415-1423.
* THESE STATEMENTS HAVE NOT BEEN EVALUATED
BY THE FOOD AND DRUG ADMINISTRATION. THIS
PRODUCT IS NOT INTENDED TO DIAGNOSE, TREAT,
CURE, OR PREVENT ANY DISEASE.
BIOS LIFE® C OTC
[bı̄-ōs lı̄f sē]
Advanced Fiber and Nutrient Drink
DESCRIPTION
Bios Life® C is a fiber-based, vitamin-rich nutritional sup-
plement. Bios Life® C contains a blend of soluble and insol-
uble fibers, phytosterols, policosanol, an extract of Chrysan-
themum morifolium, vitamins, and minerals that when
combined with a healthy diet and exercise may lower total
serum cholesterol, lower triglyceride levels and reduce the
risk of heart disease.
Bios Life® C is light orange in color. It is a hygroscopic crys-
talline powder that is generally soluble in water. Each serv-
ing of Bios Life® C contains 3 g of fiber, 1 g of phytosterols,
6 mg of policosanol, and 12.5 mg of an extract of Chrysan-
themum morifolium. In addition to these active ingredients,
each serving of Bios Life® C contains maltodextrin, citric
acid, orange juice powder, sucralose and orange flavor.
BENEFITS AND RESEARCH
It’s estimated that Americans consume 10-12 g of total fiber
per day, less than half the amount of the recommended daily
intake. Epidemiological and clinical studies have correlated
Information will be superseded by supplements and subsequent editions
low daily fiber intake with higher incidences of hyperinsu-
linemia, hypercholesterolemia, and elevated risks of cardio-
vascular disease.
Bios Life® C is a nutritional supplement designed to in-
crease daily fiber intake. Each serving of Bios Life® C con-
tains three grams of dietary fiber. When taken three times a
day, this achieves nearly half of the recommended daily
value of fiber. Fiber supplementation has been shown to de-
crease preprandial and postprandial glucose levels and
lower LDL cholesterol and apolipoprotein B levels.
In addition to fiber supplementation, Bios Life® C contains
a patented blend of phytosterols, policosanol, Chrysanthe-
mum morifolium, vitamins and minerals. This blend of in-
gredients optimizes cholesterol levels through a combina-
tion of four mechanisms. First, the soluble fiber matrix
prevents cholesterol reabsorption in the gastrointestinal
tract through bile-acid sequestration. Second, the phytoster-
ols reduce dietary absorption of cholesterol. Third, poli-
cosanol inhibits hepatic synthesis of cholesterol mediated
through HMG-CoA reductase. Fourth, Chrysanthemum
morifolium provides phytonutrients that enhance conver-
sion of cholesterol to 7-␣-hydroxycholesterol. The four
mechanisms provide a synergistic approach to optimizing
cholesterol levels. Research has shown that this product
may serve as a first line treatment option for mild hyper-
cholesterolemia, as well as adjunct therapy for lipid lower-
ing pharmaceutical intervention.
SUGGESTED USAGE
Dissolve the contents of one packet or one scoop into 8 to
10 fl. oz. of liquid (water or juice) and stir vigorously. Drink
immediately. Use 15-20 minutes prior to meals up to three
times daily.
SAFETY AND WARNINGS
Bios Life® C is well tolerated. There may be mild gastroin-
testinal discomfort, such as increased flatulence or loose
stools, during the first month of initial use due to the in-
creased uptake of dietary fiber. This GI disturbance usually
disappears within the first thirty days. If the GI discomfort
persists, reduce the number of servings of Bios Life® C. If
the GI discomfort further persists, stop taking the product
and consult your physician. Taking this product without ad-
equate liquid can result in complications. If you are a dia-
betic, consult a physician for proper use of this product, as
the chromium may reduce the need for medication.
HOW SUPPLIED
Bios Life® C is packaged in single-serving foil packets or in
bulk canisters.
REFERENCES
Sprecher, DL and Pearce GL (2002), Metabolism 51:
1166-70.
Verdegem, PJE; Freed, S and Joffe D (2005), American Di-
abetes Assocation 65th Scientific Sessions, San Diego, CA.
Duenas, V; Duenas, J; Burke, E and Verdegem, PJE (2006),
7th International Conference on Arteriosclerosis, Thrombo-
sis, and Vascular Biology, American Heart Association,
Denver, CO.
Verdegem, PJE (2007), Current Topics in Nutraceutical
Research 5: 1-6
US Patent 6,933,291.
* THESE STATEMENTS HAVE NOT BEEN EVALUATED
BY THE FOOD AND DRUG ADMINISTRATION. THIS
PRODUCT IS NOT INTENDED TO DIAGNOSE, TREAT,
CURE, OR PREVENT ANY DISEASE.
Shown in Product Identification Guide, page 329
BIOS LIFE® SLIM™ OTC
[bı̄-ōs lı̄f slim]
Advanced Fiber and Nutrient Drink
DESCRIPTION
Bios Life® Slim™ is a fiber-based, vitamin-rich nutritional
supplement. Bios Life® Slim™ contains a blend of soluble
and insoluble fibers, Unicity® 7⫻ technology, phytosterols,
policosanol, an extract of Chrysanthemum morifolium, vita-
mins, and minerals that when combined with a healthy diet
and exercise may lower total serum cholesterol, reduce the
risk of heart disease and help achieve and maintain a
healthy body weight.
Bios Life® Slim™ is light orange in color. It is a hygroscopic
crystalline powder that is generally soluble in water. Each
serving of Bios Life® Slim™ contains 4 g of fiber, 1 g of phy-
tosterols, 750 mg of Unicity 7⫻, 6 mg of policosanol and
12.5 mg of an extract of Chrysanthemum morifolium. In ad-
dition to these active ingredients each serving of Bios Life®
Slim™ contains maltodextrin, citric acid, orange juice pow-
der, sucralose and orange flavor.
BENEFITS AND RESEARCH
It’s estimated that Americans consume 10-12 g of total fiber
per day, less than half the amount of the recommended daily
PHYSICIANS’ DESK REFERENCE®
intake. Epidemiological and clinical studies have correlated
low daily fiber intake with higher incidences of obesity, hy-
perinsulinemia, hypercholesterolemia, and elevated risks of
cardiovascular disease.
Bios Life® Slim™ is a nutritional supplement designed to
increase fiber intake. Each serving of Bios Life® Slim™ con-
tains four grams of fiber. When taken three times a day this
achieves half of the recommended daily value of fiber. Fiber
supplementation has been shown to decrease preprandial
and postprandial glucose levels; lower LDL cholesterol and
apolipoprotein B levels; increase satiety and facilitate
weight loss.
In addition to fiber supplementation, Bios Life® Slim™ con-
tains a patented blend of phytosterols, policosanol, Chry-
santhemum morifolium, vitamins and minerals. Bios Life®
Slim™ facilitates weight loss through five distinct mecha-
nisms. First, the soluble fiber matrix promotes an increase
in satiety. Second, Bios Life® Slim™ improves cholesterol
levels. Reduction in LDL content removes a potent inhibitor
of lipolysis. Third, Bios Life® Slim™ improves blood glucose
levels. Maintaining appropriate serum glucose levels re-
duces hyperinsulinemia and promotes insulin sensitivity.
Reducing insulin levels permits fatty acid oxidation to oc-
cur. Fourth, Bios Life® Slim™ restores appropriate leptin
signaling. Lastly, Bios Life® Slim™, reduces triglyceride
levels allowing for leptin to cross the blood-brain barrier
and effect its mechanism of action. Research has shown that
this product may serve as a first line treatment option for
mild hypercholesterolemia, as well as adjunct therapy for
lipid lowering pharmaceutical intervention.
SUGGESTED USAGE
Dissolve the contents of one packet or one scoop into 8 to
10 fl. oz. of liquid (water or juice) and stir vigorously. Drink
immediately. Use 15-20 minutes before meals up to three
times daily.
SAFETY AND WARNINGS
Bios Life® Slim™ is well tolerated. There may be mild gas-
trointestinal discomfort, such as increased flatulence or
loose stools, during the first month of initial use due to the
increased uptake of dietary fiber. This GI disturbance usu-
ally disappears within the first thirty days. If the GI
discomfort persists, reduce the number of servings of Bios
Life® Slim™. If the GI discomfort further persists, stop tak-
ing the product and consult your physician. Taking this
product without adequate liquid can result in complications.
If you are a diabetic, consult a physician for proper use of
this product, as the chromium may reduce the need for med-
ication.
HOW SUPPLIED
Bios Life® Slim™ is packaged in single-serving foil packets
or in bulk canisters.
REFERENCES
Sprecher, DL and Pearce GL (2002), Metabolism 51:
1166-70.
Verdegem, PJE; Freed, S and Joffe D (2005), American Di-
abetes Assocation 65th Scientific Sessions, San Diego, CA.
Slavin, JL, (2005) Nutrition 21: 411-418.
Delzenne NM, Cani PD, (2005) Current Opinion Clincal
Nutrition & Metabolic Care 8: 636-640
Duenas, V; Duenas, J; Burke, E and Verdegem, PJE (2006),
7th International Conference on Arteriosclerosis, Thrombo-
sis, and Vascular Biology, American Heart Association,
Denver, CO.
Verdegem, PJE (2007), Current Topics in Nutraceutical
Research 5: 1-6
US Patent 6,933,291.
* THESE STATEMENTS HAVE NOT BEEN EVALUATED
BY THE FOOD AND DRUG ADMINISTRATION. THIS
PRODUCT IS NOT INTENDED TO DIAGNOSE, TREAT,
CURE, OR PREVENT ANY DISEASE.
BONEMATE® PLUS OTC
[bōn-māt plŭs]
Advanced Bone Health Formula
DESCRIPTION
BoneMate® Plus is specially formulated to help maintain
optimal bone health.* It contains three forms of calcium and
vitamin D to maximize absorption and aid in the support of
healthy bones, teeth, nerves, heart, and muscle tissue.
BoneMate® Plus is a light gray in color and is soluble in
water. Each serving of BoneMate® Plus contains the follow-
ing active ingredients 600mg of calcium, 300mg of magne-
sium, 30 mg of vitamin C, 2000 IU of vitamin D, 0.5mg of
boron, 5 mg of zinc, 1mg of manganese, 1mg of copper, and
20mg of vitamin K. In addition, it also contains the inactive
ingredients microcrystalline cellulose, croscarmellose so-
dium, and magnesium stearate.
PRODUCT INFORMATION
BENEFITS AND RESEARCH
Calcium is the most common mineral in the body. Almost
99% of the calcium in our body is found in the bones and
teeth. Bone is a dynamic tissue that is constantly being re-
modeled throughout our lives. A chronically low calcium in-
take in growing individuals may prevent the attainment of
optimal peak bone mass. Once peak bone mass has been
achieved, inadequate calcium intake may contribute to ac-
celerated bone loss and eventually to osteoporosis.
Vitamin D, a secosteroid that is produced by the body upon
exposure to the sun, is required for optimal calcium absorp-
tion. To ensure that calcium absorption is not limited by
inadequate vitamin D levels, BoneMate® Plus contains
2000 IU of vitamin D per serving. In addition to facilitating
calcium absorption, Vitamin D has been shown to target
over 2000 different genes in the body. Vitamin D deficiency
has been associated with increased risks for heart disease,
stroke, diabetes, depression, osteoarthritis, chronic pain,
and osteoporosis.
USAGE
Take two tablets twice daily with a meal.
SAFETY AND WARNINGS
BoneMate® Plus is well tolerated. Some gastrointestinal
discomfort may be experienced as with any dietary supple-
ment. The Food and Nutrition Board of the Institute of
Medicine has set the tolerable upper level (UL) of intake for
calcium in adults at 2,500 milligrams (mg) of calcium/day.
HOW SUPPLIED
Available as tablets or as a powder.
REFERENCES
Weaver CM, Heaney RP. Calcium. In: Shils M, Olson JA,
Shike M, Ross AC, eds. Modern Nutrition in Health and
Disease. 9th ed. Baltimore: Williams & Wilkins; 1999:
141-155.
Heaney RP. Calcium, dairy products and osteoporosis. J Am
Coll Nutr. 2000;19(2 Suppl):83S-99S.
Food and Nutrition Board, Institute of Medicine. Calcium.
Dietary Reference Intakes: Calcium, Phosphorus,
Magnesium, Vitamin D, and Fluoride. Washington, D.C.:
National Academy Press; 1997:71-145.
Reid IR. Therapy of osteoporosis: calcium, vitamin D, and
exercise. Am J Med Sci 1996;312:278-86. Food and Nutri-
tion Board, Institute of Medicine. Calcium. Dietary Refer-
ence Intakes: Calcium, Phosphorus, Magnesium, Vitamin
D, and Fluoride. Washington, D.C.: National Academy
Press; 1997:71-145.
* THESE STATEMENTS HAVE NOT BEEN EVALUATED
BY THE FOOD AND DRUG ADMINISTRATION. THIS
PRODUCT IS NOT INTENDED TO DIAGNOSE, TREAT,
CURE, OR PREVENT ANY DISEASE.
CARDIO-BASICS™ OTC
Caring for your heart*
DESCRIPTION
Cardio-Basics™ is a nutritional supplement that combines
multivitamins, minerals and antioxidants to support the
cardiovascular system.
Cardio-Basics™ is a light orange, water-soluble powder
pressed into tablets. Each tablet of Cardio-Basics™ con-
tains the following vitamins, minerals, amino acids and an-
tioxidants: beta-carotene (vitamin A), thiamine (vitamin
B1), riboflavin (vitamin B2), niacin (vitamin B3), calcium
d-pantothenate (vitamin B5), pyridoxine hydrochloride (vi-
tamin B6), folate (vitamin B9), cyanocobalamin (vitamin
B12), ascorbic acid and ascorbyl palmitate (vitamin C), cho-
lecalciferol (vitamin D), d-alpha-tocopherol (vitamin E), bi-
otin, calcium, chromium, copper, magnesium, manganese,
molybdenum, phosphorus, potassium, selenium, sodium,
zinc, L-arginine, L-carnitine, L-cysteine, L-lysine, L-proline,
inositol, coenzyme Q10, and maritime pine extract. In addi-
tion to those active ingredients each tablet also contains mi-
crocrystalline cellulose, sucrose, fatty acid esters, silicon di-
oxide, magnesium stearate, and maltodextrin.
BENEFITS AND RESEARCH
According to the Center for Disease Control and Prevention,
one American will die every minute as a result of heart
disease. Narrowing of the arterial walls can lead to blocked
blood flow to the brain. A healthy lifestyle including being
physically active, not smoking, and making good food
choices can lead to a reduction of heart disease.
Cardio-Basics™ provides the vitamins, minerals and anti-
oxidants needed for a healthy heart. In clinical studies, par-
ticipants using Cardio-Basics™ and Bio-C™ saw a signifi-
cant reduction in arterial wall thickness, removal of
calcification deposits and a reduced risk for cardiovascular
disease when compared to the placebo group. Cardio-
Basics™ provides the body with the necessary vitamins and
minerals needed to support a healthy vascular system.*
SUGGESTED USE
Take two tablets daily with food.
SAFETY AND WARNINGS
Cardio-Basics™ is well tolerated. Some gastrointestinal
discomfort may be experienced as with any dietary supple-
ment.
HOW SUPPLIED
Available in tablets
REFERENCES
Niedzwiekcki, A, Rath, M. (1996) Journal of Applied Nutri-
tion, 48: 67-78.
Jeejeebhoy, F, Keith, M, Freeman, M, Barr, A, McCall, M,
Kurian, R, Mazer, D, Errett, L, (2002), American Heart
Journal 143: 1092-1100.
Verdgem, PJE, Lonky, S, Curley, S. (2005) 7th Conference
on Arteriosclerosis, Thrombosis and Vascular Biology.
Lloyd-Jones D, Adams R, Carnethon M, DeSimone G, Fer-
guson TB, Flegal K, Ford E, Furie K, Go A, Greenlund K,
Haase N, Hailpern S, Ho M, Howard V, Kissela B, Kittner S,
Lackland D, Lisabeth L, Marelli A, McDermott M, Meigs J,
Mozaffarian D, Nichol G, O’Donnell C, Roger V, Rosamond
W, Sacco R, Sorlie P, Stafford R, Steinberger J, Hong Y;
(2009) Circulation, 119: 480-486.
* THESE STATEMENTS HAVE NOT BEEN EVALUATED
BY THE FOOD AND DRUG ADMINISTRATION. THIS
PRODUCT IS NOT INTENDED TO DIAGNOSE, TREAT,
CURE, OR PREVENT ANY DISEASE.
CARDIO-ESSENTIALS OTC
Caring for your heart*
DESCRIPTION
Cardio-Essentials is a nutritional supplement for the heart.
Cardio-Essentials contains Coenzyme Q-10, L-carnitine,
L-taurine and Hawthorn berry.
Cardio-Essentials is a light tan, water-soluble powder. Each
capsule of Cardio-Essentials contains 100 mg of Coenzyme
Q-10 and 3.5 g of a blend of L-carnitine, L-taurine, and
Hawthorn berry. In addition to those active ingredients,
each capsule also contains silicon dioxide, stearic acid and
calcium silicate.
BENEFITS AND RESEARCH
One of the leading causes of congestive heart failure (CHF),
left ventricular dysfunction, affects approximately 1.5% of
the population in the United States. CHF patients with left
ventricular dysfunction have reduced levels of Coenzyme
Q-10, L-carnitine and L-taurine and have an enlarged left
ventricle. In a clinical study, the combination of L-carnitine,
L-taurine, and Coenzyme Q10 was shown to benefit conges-
tive heart failure patients by reducing left ventricular size.
These ingredients are known to be important in providing
adequate energy for heart muscle. Cardio-Essentials pro-
vides adequate amounts of these ingredients, i.e. 100 mg of
CoQ10. Hawthorn extract is traditionally used in support-
ing the heart function.
SUGGESTED USE
Take three capsules twice a day with food.
SAFETY AND WARNINGS
Cardio-Essentials is well tolerated. Some gastrointestinal
discomfort may be experienced as with any dietary supple-
ment.
HOW SUPPLIED
Available in capsules
REFERENCES
Jeejeebhoy, F et al (2002), American Heart Journal 143
1092–1100.
* THESE STATEMENTS HAVE NOT BEEN EVALUATED
BY THE FOOD AND DRUG ADMINISTRATION. THIS
PRODUCT IS NOT INTENDED TO DIAGNOSE, TREAT,
CURE, OR PREVENT ANY DISEASE.
CM PLEX™ AND CM PLEX™ CREAM OTC
[CM plĕks]
Proprietary fatty acid blend to help alleviate symptoms
of osteoarthritis*
DESCRIPTION
CM Plex and CM Plex Cream are a softgel and topical
cream, respectively, that contain a proprietary blend of cety-
lated fatty acids, soy and fish oil.
CM Plex is an opaque powder that is insoluble in water. One
softgel capsule of CM Plex contains 350 mg of cetylated
For labeling updates or more information, please visit www.PDR.net or consult mobile PDR姞
UNICITY/3455
fatty acids, 160 mg of soy oil and 25 mg of salmon oil. In
addition to these active ingredients, each softgel capsule
contains glycerin and St. John’s Bread.
CM Plex Cream is an off-white powder that is insoluble in
water. One gram of CM Plex Cream contains 7.7 mg of cety-
lated fatty acids and olive oil. In addition to these active
ingredients CM Plex Cream also contains glyceryl stearate,
glycerin, lecithin, tocopheryl acetate, benzyl alcohol,
phenoxyethanol, carbomer, PEG-100 stearate, sodium hy-
droxide, methylparaben, propylparaben, butylparaben, eth-
ylparaben, isobutylparaben and citrus aurantium bergamia
(Bergamot) fruit oil.
BENEFITS AND RESEARCH
Cetyl myristoleate and related fatty acids have been proven
to improve joint health through their anti- inflammatory ef-
fects. A clinical study indicated that subjects exhibited im-
provements in knee flexion compared to placebo. A second
study indicated the cream is effective for improving knee
range of motion, ability to climb stairs, rise from a chair and
walk, balance, strength, and endurance.*
SUGGESTED USE
Softgels: Take one to two softgels three times daily with
meals.
Cream: Apply generously onto clean skin and gently mas-
sage until the cream disappears. Repeat 3 to 4 times daily
as necessary. For maximum results combine both products.
SAFETY AND WARNINGS
CM Plex Softgels and Cream are well tolerated. Some gas-
trointestinal discomfort may be experienced with CM Plex
Softgels as with any dietary supplement.
HOW SUPPLIED
CM Plex is available in soft gels and as a topical cream.
REFERENCES
Hesslink, R et al (2002), Journal of Rheumatology 29, 1708–
1712.
Kraemer, WJ et al (2004), Journal of Rheumatology 31,
767–774.
* THESE STATEMENTS HAVE NOT BEEN EVALUATED
BY THE FOOD AND DRUG ADMINISTRATION. THIS
PRODUCT IS NOT INTENDED TO DIAGNOSE, TREAT
CURE, OR PREVENT ANY DISEASE.
Shown in Product Identification Guide, page 329
IMMUNIZEN® OTC
[ı̆m mōō nı̆ zĕn]
DESCRIPTION
Immunizen® is a nutritional supplement for boosting the
immune system.
Immunizen® is a modestly water soluble, white crystalline
powder. Immunizen® consists of a proprietary ingredient
blend of colostrum, arabinogalactan, 1,3, 1,6 yeast beta-
glucans and lactoferrin. In addition to the active ingredi-
ents, each 835 mg capsule of Immunizen® contains natural
gelatin, stearic acid and silicon dioxide.
BENEFITS AND RESEARCH
Immunizen® combines the positive immune modulating ef-
fects of colostrum, arabinogalactans, yeast beta-glucans and
lactoferrin to boost your body’s natural defenses to foreign
antigens. Colostrum is composed of immunoglobulins that
bolster the body’s immune system by providing immunity
against various pathogens.
Beta-glucans are generally derived from the cell walls of the
yeast species Saccharomyces cerevisiae. Beta-glucans are
potent immuno-modulating agents that prime both the in-
nate and adaptive immune systems.
USAGE
Take six capsules with water one to two hours before a meal
for 10 days as needed.
SAFETY AND WARNINGS
Immunizen® is well tolerated. Some gastrointestinal dis-
comfort may be experienced as with any dietary supple-
ment.
HOW SUPPLIED
Available in capsules.
REFERENCES
Lilius EM, Marnila P. (2001), Current Opinion in Infectious
Diseases 14:295-300.
Hammarström L, Weiner CK. (2008), Advances in Experi-
mental Medicine and Biology 606: 321-343.
Chan GC, Chan WK, Sze DM. (2009), The Journal of Hem-
atology and Oncology, 2: 25-
Continued on next page
3456/UNICITY
Immunizen—Cont.
* THESE STATEMENTS HAVE NOT BEEN EVALUATED
BY THE FOOD AND DRUG ADMINISTRATION. THIS
PRODUCT IS NOT INTENDED TO DIAGNOSE, TREAT,
CURE, OR PREVENT ANY DISEASE.
OMEGALIFE-3™ OTC
[ōmĕgā-lı̄f 3]
Omega-3 Fatty Acid Supplementation
DESCRIPTION
OmegaLife-3™ is a blend of omega-3 fatty acids designed to
help maintain healthy cardiovascular and cerebral function
as well as aiding in the prevention of age-related macular
degeneration.
OmegaLife-3™ is an amber-colored, semi-viscous, fat-
soluble liquid. Each serving of OmegaLife-3™ contains the
following active ingredients 800 mg eicosapentaenoic acid
(EPA), 400 mg docosahexaenoic acid (DHA), and vitamin E.
In addition, it also contains the inactive ingredients gelatin,
glycerin, purified water, and orange oil. OmegaLife-3™ has
been molecularly distilled to ensure exceptionally pure oil
and includes orange oil to prevent a fishy after taste.
BENEFITS AND RESEARCH
Clinical research suggests that fish oil can help support
proper brain and visual function. In 2002 the FDA approved
supplementation of DHA in infant formula. DHA is poten-
tially important in fetal and infant neural development, in
that DHA and arachidonic acid have been shown to be in-
corporated into brain and retinal cell membranes—particu-
larly during the third trimester and early infant life.
DHA is the predominant structural fatty acid in the central
nervous system and in the retina of the eyes.
EPA supports the synthesis of important compounds in the
body. EPA is the precursor of thromboxane and leukotriene,
compounds involved in supporting healthy circulation. They
also promote healthy blood vessels.*
Evidence is accumulating that increasing intakes of EPA
and DHA can decrease the risk of cardiovascular disease by
preventing arrhythmias, decreasing the risk of thrombosis,
decreasing triglyceride levels, slowing the growth of ather-
osclerotic plaque, and decreasing inflammation.*
The U.S. Food and Drug Administration (FDA) has stated
that, “Supportive but not conclusive research shows that
consumption of EPA and DHA omega-3 fatty acids may re-
duce the risk of coronary heart disease.”
USAGE
Take two softgels per day with a meal.
SAFETY AND WARNINGS
OmegaLife-3™ is well tolerated. Some gastrointestinal
discomfort may be experienced as with any dietary sup-
plement. Common side effects include a “fishy” taste upon
eructation.
HOW SUPPLIED
Available in softgels.
REFERENCES
Barter P, Ginsberg HN. Effectiveness of combined statin
plus omega-3 fatty acid therapy for mixed dyslipidemia. Am
J Cardiol. 2008 Oct 15:102(8):1040-5
Lee JH, Harris WS, et al. Omega-3 fatty acids for cardiopro-
tection. Mayo Clin Proc. 2008 Mar;83(3):324-32.
SanGiovanni JP, Chew EY, Sperduto RD, et al. The relation-
ship of dietary omega-3 long-chain polyunsaturated fatty
acid intake with incident age-related macular degeneration:
AREDS report no. 23. Arch Ophthalmol. 2008 Sep;126(9):
1274-9.
SanGiovanni JP, Parra-Cabrera S, Colditz GA, Berkey CS,
Dwyer JT. Meta-analysis of dietary essential fatty acids and
long-chain polyunsaturated fatty acids as they relate to vi-
sual resolution acuity in healthy preterm infants. Pediatrics
2000;105:1292-8.
Kris-Etherton PM, Harris WS, Appel LJ. Omega-3 fatty ac-
ids and cardiovascular disease: new recommendations from
the American Heart Association. Arterioscler Thromb Vasc
Biol. 2003;23(2):151-152.
* THESE STATEMENTS HAVE NOT BEEN EVALUATED
BY THE FOOD AND DRUG ADMINISTRATION. THIS
PRODUCT IS NOT INTENDED TO DIAGNOSE, TREAT,
CURE, OR PREVENT ANY DISEASE.
VISUTEIN® OTC
[vı̆ s-u-tēn]
Clinically proven to support healthy eyes and vision.*
DESCRIPTION
VISUtein® is a nutritional supplement for maintaining
healthy eyes. VISUtein® contains lutein, anthocyanidins
Information will be superseded by supplements and subsequent editions
from bilberry, N-acetyl cysteine, zinc, mixed carotenoids
(␤⫺carotene, ␣⫺carotene and zeaxanthin) and riboflavin.
VISUtein® is a purple crystalline powder that is water
soluble. In addition to the active ingredients lutein, antho-
cyanidins, N-acetyl cysteine, zinc, mixed carotenoids and
riboflavin, each 600 mg capsule contains magnesium
stearate.
BENEFITS AND RESEARCH
Antioxidants from the carotenoid chemical family, such as
lutein and zeaxanthin, play an important role in eye health.
Low concentrations of these compounds in the retina are as-
sociated with age-related macular degeneration (AMD).
Supplementation with high levels of lutein can restore the
lutein concentration in the retina. Further supplementation
of vitamins C and E along with zinc, copper and ␤-carotene
delayed the onset of AMD. Low glutathione levels have been
shown to reduce protection of the eye against oxidative
stress. N-acetyl cysteine has been shown to elevate gluta-
thione levels in the retina. A recent clinical study with
VISUtein® has shown that AMD patients experience clear
improvements in visual acuity, contrast sensitivity, and re-
covery from a flash.*
USAGE
Take two capsules per day with a meal.
SAFETY AND WARNINGS
VISUtein® is well tolerated. Some gastrointestinal discom-
fort may be experienced as with any dietary supplement.
HOW SUPPLIED
Available in capsules.
REFERENCES
Newsome, DA and Meyers, L (2004), “A Randomized
Prospective Clinical Trial of Two Commercially Available
Ocular Diet Supplements”, In press.
* THESE STATEMENTS HAVE NOT BEEN EVALUATED
BY THE FOOD AND DRUG ADMINISTRATION. THIS
PRODUCT IS NOT INTENDED TO DIAGNOSE, TREAT,
CURE, OR PREVENT ANY DISEASE.
Shown in Product Identification Guide, page 329
Unimed Pharmaceuticals, Inc.
A Solvay Pharmaceuticals, Inc. Company
901 SAWYER ROAD
MARIETTA, GA 30062
www.solvaypharmaceuticals-us.com
FOR MEDICAL INFORMATION CONTACT:
GENERALLY:
Medical Information Department
(800) 241-1643 #8
SALES AND ORDERING:
Orders may be placed by calling this toll free number:
(800) 241-1643 #1
Fax # 770-578-5901
Mail orders should be sent to:
Solvay Pharmaceuticals
Customer Relations Department
901 Sawyer Road
Marietta, GA 30062
ANDROGEL® "嗱
[ăn drō-jĕl]
(testosterone gel)
1% for topical use
嗱 only
HIGHLIGHTS OF PRESCRIBING INFORMATION
These highlights do not include all the information needed
to use AndroGel safely and effectively. See full prescribing
information for AndroGel.
AndroGel® (testosterone gel) 1% for topical use CIII
Initial U.S. Approval: 1953
WARNING: SECONDARY EXPOSURE TO
TESTOSTERONE
See full prescribing information for complete boxed
warning
• Virilization has been reported in children who were
secondarily exposed to testosterone gel (5.2, 6.2).
• Children should avoid contact with unwashed or un-
clothed application sites in men using testosterone
gel (5.2).
PHYSICIANS’ DESK REFERENCE®
• Healthcare providers should advise patients to
strictly adhere to recommended instructions for use
(5.2).
- - - - - - - - - - - - -RECENT MAJOR CHANGES - - - - - - - - - - - - -
• Boxed Warning 9/2009
• WARNINGS AND PRECAUTIONS (5.2) 9/2009
- - - - - - - - - - - - - -INDICATIONS AND USAGE- - - - - - - - - - - - - -
AndroGel is an androgen indicated for replacement therapy
in males for conditions associated with a deficiency or ab-
sence of endogenous testosterone:
• Primary Hypogonadism (Congenital or Acquired) (1.1)
• Hypogonadotropic Hypogonadism (Congenital or Ac-
quired) (1.1)
- - - - - - - - - -DOSAGE AND ADMINISTRATION - - - - - - - - - -
• Recommended starting dose: 5 g for adult males, applied
topically once daily (2.1).
• Apply to clean, dry, intact skin of shoulders and upper
arms and/or abdomen. Do NOT apply AndroGel to the
genitals (2.1).
• Dose adjustment for adult males: If serum testosterone
level is below the normal range, adjust dose from 5 g to
7.5 g and from 7.5 g to 10 g (2.3).
- - - - - - - - -DOSAGE FORMS AND STRENGTHS - - - - - - - - -
AndroGel (testosterone gel) 1% for topical use is available
as:
• 2 ⫻ 75 g pumps (each pump dispenses 60 metered 1.25 g
doses) (3)
• 2.5 g packet or 5 g packet (3)
- - - - - - - - - - - - - - - -CONTRAINDICATIONS - - - - - - - - - - - - - - - -
• Men with carcinoma of the breast or known or suspected
prostate cancer (4, 5.1).
• Pregnant or breast feeding women. Testosterone may
cause fetal harm (4)
- - - - - - - - - - WARNINGS AND PRECAUTIONS - - - - - - - - - -
• Patients with benign prostatic hyperplasia (BPH) treated
with androgens are at an increased risk for worsening of
signs and symptoms of BPH (5.1).
• Secondary exposure to testosterone in children and
women can occur with use of testosterone gel (5.2). Cases
of secondary exposure resulting in virilization of children
have been reported (6.2).
• Children and women should avoid contact with un-
washed or unclothed application site(s) in men using
testosterone gel.
• To minimize the potential for transfer to others, pa-
tients using AndroGel should apply the product as di-
rected and strictly adhere to the following (5.2):
• Wash hands with soap and water after application.
• Cover the application site with clothing after the gel
has dried.
• Wash the application site thoroughly with soap and
water prior to any situation where skin-to-skin con-
tact of the application site with another person is
anticipated.
• Signs of virilization in children and women and the pos-
sibility of secondary exposure to testosterone gel should
be brought to the attention of the healthcare provider.
Testosterone gel should be promptly discontinued until
the cause of the virilization is identified (5.2).
• Due to lack of controlled evaluations in women and poten-
tial virilizing effects, AndroGel is not indicated for use in
women (5.3).
• Exogenous administration of androgens may lead to azoo-
spermia (5.4).
• Edema may be a complication in patients with preexisting
cardiac, renal, or hepatic disease (5.6, 6.2).
• Gynecomastia, enlargement of breast, may develop (5.7).
• Sleep apnea may occur in those with risk factors (5.8).
• Monitor serum testosterone, prostatic specific antigen, he-
moglobin, hematocrit, liver function test, and lipid levels
periodically (2.3, 5.1, 5.9).
• Alcohol-based gels are flammable until dry (5.10).
- - - - - - - - - - - - - - - -ADVERSE REACTIONS - - - - - - - - - - - - - - - -
Most common adverse reactions (incidence ⱖ 5%) are acne,
application site reaction, abnormal lab tests, and prostatic
disorders (6).
Cases of testosterone secondary exposure resulting in viril-
ization of children have been reported (6.2). Reported signs
and symptoms have included enlargement of the penis or
clitoris, premature development of pubic hair, increased
erections and libido, aggressive behavior, and advanced
bone age. In most cases with a reported outcome, these
signs and symptoms were reported to have regressed with
removal of the exposure to testosterone gel (5.2, 6.2). In a
few cases, however, enlarged genitalia did not fully return
to age-appropriate normal size and bone age remained mod-
estly greater than chronological age.
To report SUSPECTED ADVERSE REACTIONS, contact
Solvay Pharmaceuticals, Inc. at 1-800-241-1643 or FDA at
1-800-FDA-1088 or www.fda.gov/medwatch.
- - - - - - - - - - - - - - - -DRUG INTERACTIONS - - - - - - - - - - - - - - - -
• Androgens may decrease blood glucose, and therefore in-
sulin requirement in diabetic patients (7.1).