Professional Documents
Culture Documents
Sónia Velho
Instituto Português de Oncologia
Francisco Gentil, Lisboa, Portugal
Arno Mank
Academic Medical Centre
Amsterdam, Netherlands
PROGRAM
z Sónia
{ Nutrition before HSCT
z Nutritional Screening and assessment
{ Nutrition during HSCT
z Dietary counselling
z Artificial nutrition
z Specialized nutrition
{ Nutrition after HSCT
z Arno
{ Bacterial translocation
{ Low bacterial diet
{ Gastrointestinal complications
{ GVHD
{ Social and psychological aspects
{ Education
z Workshop
BEFORE
HEMATOPOIETIC STEM CELL TRANSPLANT
Malnutrition Universal
Screening Tool- MUST Nutritional Assessment
•Unintentional weight loss?
•Body Mass Index?
•Dietary intake? Nutritional Intervention
z Nutrition support
{Tailored for each patient
z Strategies:
{ Dietary counseling
{ Artificial nutrition
{ Specialized nutrition
DIETARY COUNSELING
z Low bacterial diet (discussed later in this
presentation)
z Modification of foods:
{Food preferences
{Eating ability
{Symptoms
Our experience...
First days in the Unit:
•Duration
Monitor
•Nutritional status
Consistenly low
•Disease severity ?
Artificial Nutrition
Planas M and col, Clinic Nutr (2002) 21(4):355-61
TIMING OF ARTIFICIAL NUTRITION
Risk factores Early < 3 days Delay <7-10 days
Age Children Adult
Sex Male Female
Diagnosis Chronic Acute
Disease High Low
severity index
Nutritional Malnutrition/obesity Adequate
Status
Weight loss Acute Slow
Previous 50% 50-75%
nutrient intake
Planas M and col, Clinic Nutr (2002) 21(4):355-61
ARTIFICIAL NUTRITION SUPPORT (ANS)
Timing of ANS
and
Enteral/Parenteral nutrition Nasogastric tube
TPN PPN
z Indications:
{ ↓ Oral intake
{ Nutrient repletion
{ Support during transition phase after parenteral nutrition
z Contraindications:
{ Intestinal obstruction
{ High risk of aspiration
{ Severe uncontrolled diarrhea
{ Vomiting Frequent in HSCT pts
ENTERAL NUTRITION COMPLICATIONS
z Mechanical z Metabolic
{ Nasopharyngeal mucosa { Dehydration
erosion { Glucose intolerance
{ Tube misplacement { Hipo/hiperkalemia
{ Aspiration pneumonia
{ Hipo/hipernatremia
{ Obstruction
{ Hipophosphatemia
z Gastrointestinal
{ Nausea
{ Vomiting
{ Diarrhea
{ Abdominal pain
{ Abdominal distention
PARENTERAL NUTRITION
z Integrity and functional GI status?
{ Not OK
z Indications:
{ Perioperative support
{ Short bowel syndrome
{ Severe pancreatitis
{ Mechanical intestinal obstruction
{ Severe malabsorption
{ Hyperemesis Frequent in HSCT pts
z Contraindications:
{ Prognosis not consistent with agressive nutrition
{ Risks overweigh benefits
PARENTERAL NUTRITION COMPLICATIONS
z Metabolic z Septic
{ Abnormalities in liver { Catheter (contaminated by
function tests, namely a remote source or primary
SGOT, SGPT, bilirubin, source of infection)
alkaline phosphatase
{ Hepatic steatosis z Technical
{ Cholestasis { Associated with catheter
{ Bacterial translocation insertion
{ Hyperglicemia { Phlebitis
{ Refeeding syndrome
{ Hyperlipidemia
{ Dehydratation/fluid
overload
ARTIFICIAL NUTRITION SUPPORT
z PN is associated to:
{ Better nutritional status compared with oral diet with
simultaneous IV hydration
{ Higher rate of infection, costs and hospital stay
Arends J et al, Clinic Nutr (2006) 25:245-259;Lipkin A and col, Nutr Clinc Prac (2005), 20:423-39
Parenteral vs Enteral Nutrition
z Glutamine
z Effect on:
Blood count recovery?
Mucositis?
Contradictory data
Ziegler T, BJ Nut (2002),87, Suppl. 1 S9-S15;Anderson PM e col, BMT (1998), 22, 339-44
ANTIOXIDANTS
• Anti-inflammatory
16 Consecutive HSCT patients: 1,8g/day of EPA; 3 weeks before till Day + 180
↓ leucotriene B4, tromboxane A2, prostaglandin I2 (p<0,01)
↓ TNFα, IFN, IL10 (p<0,05)
↑ Survival rate (p<0,01)
Muscaritoli M and col Am J Clin Nutr (2002), 75:183-90;Takatsuka H et al BMT (2001) 28, 769-774
POST-TRANSPLANT
(AFTER RECOVERING BLOOD COUNTS)
1. Survival
2. Body Composition
AFTER HSCT
z ↑ Mortality:
{ Day +150; pts with weight < 85% or 85%-95% of their ideal weight
Kyle et al BMT (2005), 35: 1171-7,Nysom K BMT(2001), 27:817-20,Deeg HJ and col BMT (1995) 15, 461-68
CONCLUSION
z Sónia
{ Nutrition before HSCT
z Nutritional Screening and assessment
{ Nutrition during HSCT
z Dietary counselling
z Artificial nutrition
z Specialized nutrition
{ Nutrition after HSCT
z Arno
{ Bacterial translocation
{ Low bacterial diet
{ Gastrointestinal complications
{ GVHD
{ Social and psychological aspects
{ Education
z Workshop
BACTERIAL TRANSLOCATION
z Bacteria in the gastrointestinal tract can travel
through the mucosa to infect the mesenteric lymph
nodes and body organs
(accepted) Mank, A.P., Davies, M. Examining Low Bacterial Dietary Practice: A European
Survey on Low Bacterial Food European Journal of Oncology Nursing. 2008
Are there guidelines during hospitalisation/ After discharge?
100
90
80
70
60
Autologous
50
Allogeneic
40
RIST
30
20
10
0
During After
Under which conditions does the guideline suggest that
low bacterial food should be given?
40
35
At admission
30
As chemotherapy
25
is started
20 As certain blood
value is reached
15
As preventive
10 antibiotics starts
5 Others
0
Autologous Allogeneic
Start and Stop
Conditions LBD should be started Admission Start chemo Dependant on blood value Start AB others
(Autologous SCT)
37/34.3 25/23.1 27/25.0 9/8.3 5/4.6
Conditions LBD should be started Admission Start chemo Dependant on blood value Start AB others
(Allogeneic SCT)
33/30.6 23/21.3 20/18.5 9/8.3 5/4.6
Conditions LBD should be stopped Discharge Dependant on blood value Stop AB others
(Autologous SCT)
Conditions LBD should be stopped Discharge Dependant on blood value Stop AB others
(Allogeneic SCT)
19
no
12
forbidden
77
58 product restrictions
6 process restrictions
Peeled
Soft Fruit
Guidelines (N=108)
{BMI: 5
{Weight: 52 (10% loss)
{Nutritional intake: 15
{TPN: 9
{Nutritional supplements: 7
{Calories: 6
Cochrane Review 1.
Cochrane
Central
Medline to Embase to Cinahl to
Register of
December December December
Controlled Trials
2006 2006 2006
to December
2006
58
potential titles
identified 3 reviewers
independently
read the
abstracts and
Inclusion criteria
applied the
- RCTs
inclusion criteria
- quasi-RCTs
- cohort studies
- case control studies
- both adults and children
(> age 1 year) with
compromized immune
systems who
receive chemotherapy
causing neutropenia
3 studies identified
for systematic
review
Cochrane review 2. (preliminary results)
zVariety in implementation
zCytoreductive therapy.
zMedications (anti infectious and/or
immunosuppressive agents) may cause
anorexia, nausea, vomiting and diarrhoea.
zInfections.
zGraft Versus Host Disease.
zVenooclusive disease of the liver
Infection
zCommon complication
zFever-loss of appetite
zVRE& C Diff- diarrhoea
zIncreased cytokine release
zIncreased metabolism
zTissue damage
Frequently occurring nutritional problems in
HSCT patients
z Sore throat and mouth
z Decreased salivation and dry mouth
z Lack of appetite (anorexia)
z Nausea, vomiting and food aversion
z Early satiety
z Alteration in smell and taste
z Loss of taste
z Mucositis / oesophagitis
z diarrhea
z Malabsorption
Taste changes
z Frequent complication
60-100%
z Ulceration, pain,
thickened saliva,
bleeding
z Often require opiates
z Main indication for
artificial nutrition
Mucosal barrier injury
(MBA)
zDepression
zIsolation Loss of
appetite
zFear
zLearned behaviour
Environmental-Isolation
z Repetitive menus
z Limited choice
z Start from products which the patient likes and which are
easy to eat and drink.
z Use small meals and take snacks frequently.
z Encourage the patient to eat something every day.
z Offer the patient the possibility to choose from a broad
selection of foods.
z Of course a pleasant presentation of the food is
important.
Coffee break
Workshop on Nutrition and
Hematopoietic Stem Cell
Transplantation
Program
Sonia
z Nutritional risk assessment
z Oral nutritional supplements
{ Indication
{ Supplements vs regular food stuffs
z Artificial Nutrition
{ When to start?
{ Type of Artificial Nutrition?
Arno
z Low bacterial Diet
z Nutritional Therapy for GI complications associated with HSCT
z Nutrition Guidelines
NUTRITIONAL RISK SCREENING?
1 Medium Risk-Observe
Document dietary intake for 3 days,
If no improvement – clinical concern → follow local policy
Repeat screening weekly
Conditions LBD should be started Admission Start chemo Dependant on blood value Start AB others
(Allogeneic SCT)
33/30.6 23/21.3 20/18.5 9/8.3 5/4.6
Conditions LBD should be stopped Discharge Dependant on blood value Stop AB others
(Autologous SCT)
Conditions LBD should be stopped Discharge Dependant on blood value Stop AB others
(Allogeneic SCT)
{ BMI: 5
{ Weight: 52 (10% loss)
{ Nutritional intake: 15
{ TPN: 9
{ Nutritional supplements: 7
{ Calories: 6