Professional Documents
Culture Documents
Final Review
Migration of Endothelial
Cells into Interstitium
Lumen Formation
Generation of New
Basement Membrane
Curative Chemotherapy
– Leukemia, Lymphoma, Germ Cell Cancer
Adjuvant Chemotherapy
– Improve Survival After Surgical Resection
– Improve Survival When Given With Radiation
P lli ti Ch
Palliative Chemotherapy
th
– Relieve Pain, Dyspnea, Performance Status
– Modestly Improve Life Span
Mechanism
M h i off A
Action
ti
Metabolism
Toxicity
CC-Pieters & Liebmann Feb 11 2011
Classes and
Cl d Mechanisms
M h i off
Chemotherapy Drugs
Immune
u e Therapies:
e ap es Interferon,
te e o , IL-2
Antibodies: Trastuzumab, Cetuximab, Rituximab
TK Inhibitors: Erlotinib, Sunitinib, Lapatinib
Platinum Compounds: Cisplatin, Carboplatin,
Oxaliplatin
Hormonal Agents
Agents: Tamo
Tamoxifen,
ifen Aromatase Inhibitors
(Anastrazole), LHRH Agonists
Myelosuppression – Common
– Exceptions:
E ti Vi
Vincristine,
i ti Bleomycin,
Bl i TKI
TKIs,
Antibodies, Cisplatin
Nausea – Cisplatin,
Cisplatin Nitrogen Mustard
Mustard, Doxorubicin,
Doxorubicin
Nitrosureas
Renal – Cisplatin
Neurotoxicity – Vincristine, Taxanes, Cis-/Oxalo-
platin
Cardiac – Doxrubicin,
Doxrubicin Trastuzumab
• Tobacco Cessation
• Diet and Cancer
– No evidence for supplements
• Surgery to Prevent Cancer
– In cancer family syndromes
• Drugs to Prevent Cancer
– Finasteride: Prostate Cancer
– Tamoxifen,
Tamoxifen Raloxifene: Breast Cancer
• Vaccines to Prevent Cancer
– Hepatitis B: Hepatocellular Cancer
– Papilloma
p Viruses: Cervical,, Head and Neck Cancers
• Staging • Grading
– Films, Physical Exam – Histology
– Macroscopic Extent – Microscopic Appearance
– Strong Prognostic Value – Some Prognostic Value
– Strong Therapeutic Value – Little Therapeutic Value
– Uses T, N, M System – Uses Morphologic Guidelines
Different Cancers
– Few Carcinomas, More Leukemias
Prediliction for Cancer at Unique Ages
– Growth
G hS
Spurts
Less Association With Environmental Factors
Stage Much Less Important
Cancer is Less Common
Relax
Get a Good Night’s Sleep
concept ((ˈkɒnsɛpt)
kɒnsɛpt) — n 1.
1 an idea
idea, esp an
abstract idea
– Obsess Less Over Trivia
– Worry More About Understanding the Concepts