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COMMUNICABLE DISEASE- an illness due to a specific agent or its toxic products, arising
through transmission of that agent or its products from reservoir to susceptible host, either
directly from an infected person or animal, or indirectly through the agency of an intermediate
plant or animal host, a vector or the inanimate environment.
INFECTION- the entry and development or multiplication of an infectious agent in the body of
man or animal.
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The relation of severity of illness to disease statistics:
INFECTION
DISEASE
(A) (B) (C) (D) (E)
Likely to be seen by a
Doctor; may be recorded
Likely to be
Hospitalized &
recorded
Infectious Disease Process
ID50 – the minimum number of particles or agents required to establish infection in 50% of a
group of hosts of the same species.
Varies with: agent, route of administration of the agent, source of the agent, and host factors,
such as age or race.
Example: High infectivity- measles
Low infectivity-leprosy
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Measure of virulence-CFR
Factors that affect virulence: dose, route of infection, host factors such as age or race.
Pathogenetic Mechanisms:
1. Direct tissue invasion, e.g. parasitic diseases such as amoebiasis, giardiasis, and many
nematodes, trematodes and cestodes, bacterial meningitides, UTI, pharyngitis or otitis,
skin abscesses, and viral infections, such as upper respiratory or gastrointestinal viruses,
and encephalitis (rabies, arbovirus encephalitides)
2. Production of a toxin, e.g. tetanus, diptheria, and infections by enterotoxigenic E. coli.
3. Immunologic enhancement or allergic reaction leading to damage of the host, e.g. TB, post
streptococcal GN, dengue h. fever.
4. Persistent or latent infection
e.g. pharynx- H. influenzae, streptococci;
gallbladder- salmonella typhi;
urinary tract- E. coli, Serratia, pseudomonas;
persistent viral infection- herpes I &II, varicella zoster, CMV, Hep B, measles
5. Enhancement of host susceptibility to drugs or otherwise minimal toxicity, e.g. Reye’s
syndrome.
6. Immune suppression, e.g. AIDS
Reservoir- defined as the living organisms or inanimats e matter ( such as soil) in which an
infectious agent normally lives and multiplies. The reservoir is an essential component of the
cycle by which an infectious agent maintains and perpetuates itself.
a. Simplest Cycle
e.g. most of the viral and bacterial respiratory diseases, most staphylococcal and
streptococcal infections, diptheria, venereal diseases, childhood exanthemata, mumps,
typhoid fever, amoebiasis, etc.
b. human is not an essential part (usual reservoir) of the lifecycle of the agent:
Human
c. Complex cycle- multiple reservoirs and different developmental stages of the agent.
E.g. echinococcosis, tapeworm infestations, schistosomiasis, malaria, and
vectorborne viral infections.
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Kristel, Leiza
Humans as reservoirs: Cases and Carrier
Range of reaction to the occurrence of infection:
1. Colonization- e.g the presence of Staphylococcus aureus on the nasal mucosa.
Contamination- presence on the surface of the body or on inanimate objects (fomites) of
an infectious agent that can serve as a source of infection.
2. Inapparent infection- (covert or subclinical) organisms not only multiply in the host, but
also cause a measurable reaction that, however, is not clinically detectable.
3. Infectious disease- when infection leads to clinical (overt) disease with symptoms, physical
findings, or both.
Carrier- an infected person who does not have apparent clinical disease, but is, nevertheless, a
potential source of infection to others.
2. Indirect transmission
– vehicleborne
– vectorborne
– airborne (droplet nuclei and dust)
Incubation period- time interval between the receipt of infection and the onset of illness.
2. Herd Immunity- resistance of a group to invasion and spread of an infectious agent, based
on the immunity of a high proportion of individual members of the group.
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3. Secondary Attack Rate- no. of cases of a disease developing during a stated period of time
among those members of a closed group who are at risk
1. sporadic
2. endemic
3. epidemic
4. pandemic
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