ED OLIVER

3403 Vargis Circle Apt. 3A * Windsor Mill, Maryland 21244-5547

(410) 949-5475 * eo80e3d4@westpost.net

MEDICINAL/ORGANIC CHEMISTRY
Research Associate * Research Chemist
Proven medicinal and organic chemistry research associate and chemist with 10 ye
ars of experience in synthesis, purification and characterization of compounds.
Adept developing, implementing and performing organic reactions. Proficient in m
aintaining laboratory notebooks.
* Designed and synthesized peptide antagonists and peptide agonists for the Zonu
lin receptor for the treatment of Celiac's disease.
* Advanced synthesis of deuterated uridine monophosphate and deuterated cytosine
monophosphate as molecular probes to determine mechanism of action in retroviru
s assemble.

AREAS OF EXPERTISE
Multi-Step Organic Synthesis * 1D & 2D 1H/13C NMR Bruker Systems * Waters Quadru
pole UV/MS
Mass Spectroscopy Analysis * Waters LC/MS ZQ * HPLC * Thin Layer Chromatography
Flash Chromatography * Isco CombiFlash Rf & Companion * Acquity UPLC * Distillat
ion
PROFESSIONAL HISTORY
PROSPECT PHARMA, INC., Columbia, Maryland * 2009-Feb 2010
Contractor
Operated safe and effective formulation/synthesis/application lab. Managed proje
cts to ensure and maintain alignment with research objectives to move projects t
o completion. Developed reports and recorded results in lab notebook. Supported
R&D and process development procedure. Created and delivered high-impact present
ations. Maintained inventory of lab supplies, reagents, solvent, dry ice and va
rious gas cylinders.
Major Contributions:
* Advanced synthesis of deuterated uridine monophosphate and deuterated cytosine
monophosphate as molecular probes to determine mechanism of action in retroviru
s assemble.
* Synthesized phosphotriesters and ribofuranose derivatives as key intermediates
.
CUBIST PHARMACEUTICALS, Lexington, Massachusetts * 2009
Contractor
Conducted laboratory research based on structure activity relationship studies u
sing conventional organic chemistry techniques. Maintained vacuum pumps. Segrega
ted and monitored solid and liquid waste levels. Fostered vendor relationships.
Major Contributions:
* Functionalized natural product to inhibit growth of staphylococcus and strepto
coccus via incorporation of various amide bonds and ether linkages.
ALBA THERAPEUTICS INC., Baltimore, Maryland * 2007-2009
Scientist I
Coordinated multi-step solid phase and multi-step solution phase organic chemist
ry to synthesize, purify and characterize peptide/small molecule antagonists and
peptide antagonists. Maintained and operated Waters Prep HPLC and Waters Mass L
ynx LC/MS. Documented organic reaction methods and procedures in lab note book.

ED OLIVER * Page 2 * (410) 949-5475 * eo80e3d4@westpost.net

ALBA THERAPEUTICS INC. (continued)

Major Contributions:
* Designed and synthesized peptide antagonists and peptide agonists for the Zonu
lin receptor for the treatment of Celiac's disease.
* Performed research highlighted in Bioorganic Medicinal Chemistry Letters (Vol.
18, Issue 16).
GUILFORD PHARMACEUTICALS/MGI PHARMA, INC., Baltimore, Maryland * 2001-2007
Research Associate II
Assisted in implementation of clinical research projects for inhibitors for Dipe
ptidyl Peptidase IV (DPPIV), Glutamate Carboxypeptidase (GCP II, NAALADase), Ser
ine Racemase, Poly(ADP-ribose)polymerases (PARP), Poly(ADP-ribose) glycohydrolas
e (PARG) Silent Information Regulator 2 (SIR2), D-amino-acid oxidize (DAAO). Co-
developed research protocol and case reports for design and synthesis of nucleos
ides. Filed patent disclosures. Ensured accurate data collection and documentati
on to track project progress. Delivered high-impact presentations on molecules a
ssociated with DPP IV project.
Major Contributions:
* Synthesized new class of small heterocyclic molecules that inhibited (low nM)
DPP IV; performed scale-up for compound series to determine potency in other ass
ays.
* Performed research on series of compounds highlighted Current Topics in Medici
nal Chemistry, 2007, 7(6):597-608.
MARTEK BIOSCIENCES CORP., Columbia, Maryland * 1997-2001
Research Chemist
Conducted exploratory research to produce new knowledge of small molecules that
penetrate the blood-brain barrier. Conceived, organized and executed project to
increase discovery of small molecule deuterated triple back-bone labeled amino a
cids. Performed qualitative and quantitative chemical analysis and recorded org
anic reaction methods and procedures in a laboratory note book. Presented resea
rch results. Maintained Bruker 200 MHz NMR system and performed cryogenic nitrog
en fills. Oversaw waste segregation and disposal.
Major Contributions:
* Advanced understanding of isotopically labeled amino acids and 2-D NMR and the
ir application as tools to determine topography of active sites within enzymes.
* Performed research whose results were published in The Journal of the American
Chemical Society, 1999, 121, 11871-11874.
EDUCATION & TRAINING
Master of Science in Organic Chemistry
University of Maryland, College Park, Maryland
Bachelor of Science in Chemistry
College of Staten Island, City University of New York, New York
NMR Spectroscopy: Methods, Interpretation and Strategies for Problem Solving
ACS Short Course
Heterocyclic Chemistry (course work)
ARKIVE Short Course

ED OLIVER * Page 3 * (410) 949-5475 * eo80e3d4@westpost.net

SELECTED PUBLICATIONS
Li, Min.; Oliver E.; Kitchens, K.M.; Vere, J.; Alkan, S.S; Tamiz A.P.; Structure
Activity Relationship Studies of Permeability Modulating Peptide AT-1002. Bioo
rg. Med. Chem. Lett. Volume 18, Issue 16, 15 August 2008, pages 4584-4586.
Ferraris, D.; Belyakov, S.; Li,W.; Oliver, E.; Ko, Y.S.; Calvin, D.; Lauter, S.;
Thomas B.; Rojas, C.; "Azetidine-based inhibitors of Dipeptidyl Peptidase IV"
Current Topics in Medicinal Chemistry, 2007; 7(6):597-608.
Li, W.; Oliver, E.; Rojas, C.; Lauter, S.; Thomas, B.; Belyakov. S.; Potent and
selective azetidine-based Dipeptidyl Peptidase IV (DPPIV) inhibitors. Abstracts
of Papers, 229th ACS National Meeting, San Diego, Ca, United States, March 13-1
7, 2005. (2005), MEDI-207.
W. Li, E. Oliver, C. Rojas, V. Kalish, S. A. Belyakov, Pat. Appl. WO 071454 (200
4).
Giesen, Alezander W.; Bae, Lennette C.; Barrett, Christa L.; Chyba, Jason A.; Ch
aykovsky, Michael M.; Cheng, Minn-Chang; Murray, Jeny H.; Oliver, E.; Sullivan,
Sarah M.; Brown, Jonathan Miles.; Homans, Steve W. 1H-filtered correlation exp
eriments for assignment and determination of coupling constants in backbone labe
led proteins. J. Biomol. NMR, 2002, 22, 21-26.
Giesen, Alezander W.; Bae, Lennette C.; Barrett, Christa L.; Chyba, Jason A.; Ch
aykovsky, Michael M.; Cheng, Minn-Chang; Murray, Jeny H.; Oliver, E.; Sullivan,
Sarah M.; Brown, Jonathan Miles.;
Dahlquist, Frederick W.; Homans, Steve W. "Measurement of one-bond 1Ha-13Ca cou
plings in backbone-labeled proteins", J. Biomol. NMR 2001, 19, 255-260.

SOFTWARE COMPETENCIES
Microsoft Excel, PowerPoint * ChemDraw * Isis Draw * Discovery Gate
Belstein * SciFinder