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Abstract
Purpose: Nasopharyngeal cancer (NPC) is a rare malignancy also seen in 10 patients. Twenty-two patients (68.8%) were
in Newfoundland and Labrador (NL), and little is known disease-free 12 months after diagnosis, half of these pre-
about risk factors and preferred treatment in this unique senting with Stage IV at diagnosis. As of September 2010,
patient population. The purpose of this study is to review 20 patients (62.5%) were alive.
outcomes of NPC patients in NL and determine if these Median disease-free survival (DFS) and overall survival
outcomes are associated with stage at diagnosis and/or (OS) were greatest in Stage II patients, at a median of 39
treatment given. and 50 months, respectively. Finally, when comparing OS
by treatment, patients who had chemoradiation did better
Methods: This retrospective chart review includes all patients than those with radiation alone (42 vs 21 months).
seen at the Dr. H. Bliss Murphy Cancer Centre from 2002
to 2009 who were diagnosed with Stage I–IV NPC. Conclusion: Our findings show that the majority of patients
Patients received either radiation alone or concurrent with NPC in NL present at an advanced stage, and as expected,
chemoradiation. Information collected included patient outcomes are worse for more advanced stages at presentation.
demographics, treatment received, recurrence and survival In our cohort, no significant difference in OS was seen
outcomes. Outcomes were then compared based on stage between patients treated with radiation only vs those treated
and treatment (concurrent chemoradiation vs radiation alone). with chemoradiation. However, Stage III and IV patients
had longer OS with the addition of chemotherapy to radiation
Results: Out of 37 patients identified using the provincial treatment. Future studies should target differences in sub-
tumour registry, 32 cases met our criteria. Sixteen patients populations based on World Health Organization (WHO)
(50.0%) presented as Stage IV. Local recurrence was docu- type, ethnicity, Epstein-Barr virus (EBV) status and other
mented in 10 patients (31.3%), and metastatic disease was risk factors for NPC.
keywords
Nasopharyngeal cancer, Newfoundland and Labrador
Introduction
Nasopharyngeal cancer (NPC) is a rare and understudied
form of cancer. In Canada, there were only 228 new
reported cases in 2005, making it a mere 0.3% of total new
cancer cases.1 Similarly, in the US2 and UK,3 NPC accounts
Dawn Armstrong, MD is an Internal Medicine Resident at for only about 1 out of every 1000 diagnosed cancers.
Memorial University, Newfoundland. Email: dawn.armstrong@mun.ca; Interestingly, in Asia, rates of NPC are estimated as high
Erin Powell, MD, FRCPC is a Clinical Assistant Professor in as 21 in 1000 men, pointing to an undetermined interplay
Medical Oncology at Memorial University; Melanie Seal, MD, of both environmental and genetic factors.4,5 Because of its
FRCPC is an Assistant Professor of Medical Oncology at Memorial low incidence, little is known about the risk factors for
University; Stewart Rorke, MD, FRCPC is a Clinical Assistant developing NPC in North America.6
Professor in Medical Oncology at Memorial University; Kara Laing, NPC is also characterized by its poor prognosis. Like many
MD, FRCPC is an Associate Professor of Medical Oncology at other cancers, prognosis is related to stage at diagnosis,
Memorial University; Pradip Ganguly, MD, FFRCSI is a Clinical with worse prognosis at higher stages.7 NPC is divided into
Associate Professor of Radiation Oncology at Memorial University; 4 stages using the American Joint Committee on Cancer
Craig Pochini, MD, FRCPC is a Clinical Assistant Professor of (AJCC) designated staging by TNM classification. Because of
Radiation Oncology at Memorial University; Farah McCrate, its anatomic location and often vague presenting symptoms,
MSc, PhD candidate at Memorial University, contributed to the most NPC cases are diagnosed at Stages III and IV.
statistical analysis for this article; Joy McCarthy, MD, FRCPC is a Standard treatment for NPC includes high-dose external
Clinical Assistant Professor in Medical Oncology at Memorial University. beam radiation therapy, with the addition of cisplatin-based