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D) Directly Interfere with Purine synthesis
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Correct Answer is C
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EXP : Methotrexate is a antimetabolite that cause inhibition of Dihydrofolate reductase and synthesis of
folic acid that required in the synthesis of thymidylic acid and purine nucleotides and finally DNA
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synthesis.
A) Chlorambucil
B) Cyclophosphamide
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C) Mustine
D) Methotrexate
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Correct Answer is D
EXP : Except methotrexate all are alkylating agents cause alkylation of guanine base of DNA and
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A) Asparaginase
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B) Topoisomerase
C) Adenosine deaminase
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Correct Answer is B
EXP : Doxorubicin acts by inhibiting topoisomerase-II enzyme and interfere with DNA synthesis.
A) Cyclophosphamide
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B) Chlorambucil
C) Fluorouracil
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D) Doxorubicin
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Correct Answer is C
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A) Limiting Cancer cell permeability
6) One of the following drug interfere with cellular metabolism, especially the synthesis of mycolic acid.
IdentifyA) Chloremphenicol
B) Pyrazinamide
.b
D) Nicotinamide
Correct Answer is C
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A) Choline esterase
B) Lipase
C) Amylase
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D) Azoreductase
Correct Answer is D
8) Erythromycin is
A) a cephalosporin
B) a penicillin
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C) a macrolide
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D) a sulphonamide
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Correct Answer is C
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A) Ciprofloxacin
B) Sparfloxacin
C) Moxifloxacin
D) Ofloxacin
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Correct Answer is C
B) Resistant P. falciparum
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C) Resistant P. vivax
D) Relapsing P. vivax
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Correct Answer is B
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drug in its usual concentration. Now the flow property of X comes in the range of 5-15. The excepient Y
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A) A lubricant
B) A glidant
C) A Binder
D) both a and b
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Correct Answer is B
EXP : Glidant is used to enhance flow property. The percentage compressibility in 5-15 is excellent.
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(Table 8.4 Lachman). Glidants are talc-5%,corn starch 5-10 %, colloidal silica such as Cab-o-Sil or
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aerosol 0.25-3 5 concentration. This part is important and to be studied with proper attention.
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A) Ratio of unionized lipophilic and hydrophilic drug concentration
13) A weakly acidic drug A with acid dissociation constant (pKa) 1.2 was administered orally. Calculate
A) 1%
.b
B) 0%
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C) 1%
D) 1.00%
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Correct Answer is B
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constant, the percentage ionized fraction is equal to unionized means both are equal i.e. 50%.
A) Increases
B) Decreases
C) Remains as such
Correct Answer is B
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EXP : When Zeta potential decreases flocculation occurs because of cohelesence of the particles due to
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reduced free energy.
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15) Suspending agents commonly used in suspensions act through following most appropriate
mechanism:
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A) Reducing interfacial tension
C) Increases viscosity
D) Decrease viscosity
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Correct Answer is C
EXP : Thickning agets are used as suspending agents to make particles suspended in the continuous
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phase.
A) W/O emulsion
B) Microemulsion
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C) O/W emulsion
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Correct Answer is B
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17) An o/w emulsion is stabilized with sodium stearate; upon addition of calcium chloride lead to
A) Breaking of emulsion
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B) Creaming of emulsion
C) Phase inversion
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D) Coalescence
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Correct Answer is C
18) Which of the following type of surfactant category A is commonly used to produce stable emulsions:
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A) Anionic surfactant
B) Cationic surfactant m
C) Nonionic surfactant
A) Surfactants
B) Preservatives
.b
C) Antioxidants
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D) Sequestering Agents
Correct Answer is A
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B) pH scale-Sorenson
Correct Answer is C
A) 2002
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B) 1999
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C) 2005
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D) 2009
Correct Answer is C
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22) Rohit made and invention in India. He wish to file a patnt in India, USA,EUROPE, Australia, China
Correct Answer is C
EXP : Economic mode of patent filing in many country to save money and time is PCT filing. In this
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process One application filed to the selected patent office would serve the purpose of filing in
designated
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countries. He need not to file in individual country. there is no such term like International Patent.
23) One drug X is having angle of repose 27 while other Y is having 40.Which is having good flow
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property.
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A) X
Correct Answer is A
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A) Particle radius
B) Particle volume
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C) Particle surface area
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D) none of the above
Correct Answer is B
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EXP : By coulter counter method the volume diaplaced of electrolyte by the particle that pass through
the pore. From this data various data like particle size radius can be calculated
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25) is a lactam antibiotic having an oxepenam ring
A) SALBACTUM
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B) PENICILLIN
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C) CLAVULANIC ACID
D) CEPHALOSPORIN
Correct Answer is C
.b
26) Streptomycin is a
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Correct Answer is B
A) sulfabenzamide, sulfathiazole,sulfamethoxazole
B) sulfabenzamide,sulfacetamide, sulfathiazole
C) sulfabenzamide,sulfapyrazine,sulfamethoxazole
D) sulfapyrazine,sulfamethoxazole, sulfisoxazole
Correct Answer is B
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28) The rings present in penicillinG are
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A) oxazolidine and lactam ring
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B) isoxazole and lactam ring
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D) piperazine and lactam ring
Correct Answer is C
A) milk
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B) antacids
C) sucralfates
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D) All of these
Correct Answer is D
.b
A) vidarbine
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B) acyclovir
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C) ganciclovir
D) foscarnet
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A) amantadine
B) ribavirin
C) foscarnet
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D) didanosine
Correct Answer is A
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32) A patient hypersensitive to metronidazole is suffering from pseudomembranous colitis; what would
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be you suggest for P colitis?
A) Doxycycline
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B) Vancomycinb
C) Clindamycin m
D) Chloramphenicol
Correct Answer is B
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33) IUPAC name of Amodiaquine
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A) 4-[(7-chloro-4-quinolynyl)amino]-2-[(diethylamino)methyl]phenol
B) N-(6-methoxy-8-quinolynyl)pentanediamine phosphate
C) 7-[(4-chloro-3-quinolynyl)amino]-2-[(diethylamino)methyl]-phenol
.b
D) N-(6-methyl-7-quinolynyl)pentanediamine phosphate
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Correct Answer is A
A) Artemether
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B) Quinacrine
C) Biguanide
D) Primaquine
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Correct Answer is C
A) Pyrimethamine
B) Trimethoprim
C) Both
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D) none of the above
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Correct Answer is A
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36) Which of the following is not a O- lactamase inhibitor
A) Thienomycin
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B) Tazobactam
C) Clavulanic acid
D) Piperacilline
Correct Answer is D
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37) IUPAC name of cloxacilline
A) 5-methyl-3-(2chlorophenyl)-4-isoxazolylpenicilline
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B) 5-methyl-3-(2,6-chlorophenyl)-4-isoxazolylpenicilline
C) 5-methoxy-3-(2,6-chlorophenyl)-4-isoxazolylpenicilline
.b
D) 3-methyl-5-(2chlorophenyl)-4-isoxazolylpenicilline
Correct Answer is A
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A) Sulbactam
B) Cilastin
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D) Biapenem
Correct Answer is B
39) Cloxacillin is
m
B) Beta lactamase inhibitor
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D) none of the above
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Correct Answer is C
40) A weakly acidic drug A with acid dissociation constant (pKa) 1.2 was administered orally. Calculate
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the theoretical percentage drug ionized present in stomach?
A) 0% m
B) 1%
C) 1%
ar
D) 1%
ph
Correct Answer is A
41) Hydrophobic drugs decreases their rate of dissolution with increase in effective surface area WHY?
D) Both a & b
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Correct Answer is D
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B) Michaelis-menton kinetics
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Correct Answer is A
43) Select the formula to calculate steady state concentration follow I/V infusion model....
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B) Css= Clearance/ Infusion rate
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C) Css= Infusion rate x Clearance
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D) Css= Infusion rate + Clearance
Correct Answer is A
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44) Drug elimination involves....(ADME are steps of pharmacokinetics)
A) ADME
B) DME
C) ME
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D) E Only
Correct Answer is C
ph
C) Both a & b
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D) All of these
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Correct Answer is D
B) Strictosidine synthetase
C) Strychine synthetase
D) Eserine synthetase
Correct Answer is B
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47) The biosynthetic precursor of quinine & cinchonidine is&
A) Tryptophen only
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B) Tryptophen & lysine respectively
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C) Lysine & tryptophen respectively
D) Lysine only
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Correct Answer is A
48) Assay limits for Barbados aloe & cape aloe are& . m
A) Equal or more than 28% & 18% respectively
Correct Answer is A
A) Quinine only
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B) Cinchonine only
Correct Answer is C
A) TLC (210nm)
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B) TLC (250nm)
C) TLC (220nm)
D) TLC (290nm)
Correct Answer is B
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