Agenda of Invited Speakers

Fourth Annual Personalized Health Care National Conference at The Ohio State University The Future of P4 Medicine and Its Impact on Clinical Care

October 6
8:30-8:40 a.m. Welcome Steven G. Gabbe, MD; Senior Vice President for Health Sciences, The Ohio State University; CEO, The Ohio State University Medical Center 8:40-8:50 a.m. Opening Remarks and Introduction of Keynote Speaker Clay Marsh, MD; Senior Associate Vice President for Health Sciences Research, The Ohio State University Medical Center; Vice Dean Research, The Ohio State University College of Medicine; Executive Director, Center for Personalized Health Care, The Ohio State University Medical Center 8:50-9:35 a.m. Keynote Speaker: Targeted Cancer Therapies William Dalton, MD, PhD; CEO and President, H. Lee Moffitt Cancer Center & Research Institute 9:35-10:20 a.m. Keynote Speaker: Causes and Consequences of microRNA Dysregulation in Cancer Carlo Croce, MD; The John W. Wolfe Chair in Human Cancer Genetics, The Ohio State University; Professor and Chairman, Department of Molecular Virology, Immunology & Medical Genetics, The Ohio State University 10:20-10:55 a.m. Panel Discussion: Novel Approaches in the Prediction and Treatment of Cancer Moderator: Clay Marsh, MD; Senior Associate Vice President for Health Sciences Research, The Ohio State University Medical Center; Vice Dean Research, The Ohio State University College of Medicine; Executive Director, Center for Personalized Health Care, The Ohio State University Medical Center Presenters/Panelists: o Michael Caligiuri, MD; Director, The Ohio State University Comprehensive Cancer Center; CEO, James Cancer Hospital and Solove Research Institute, The Ohio State University Medical Center

o Carlo Croce, MD; The John W. Wolfe Chair in Human Cancer Genetics, The Ohio State University; Professor and Chairman, Department of Molecular Virology, Immunology & Medical Genetics, The Ohio State University o William Dalton, MD, PhD; CEO and President, H. Lee Moffitt Cancer Center & Research Institute 10:55-11:10 a.m. Break 11:10-11:15 a.m. Introduction of Keynote Speaker Clay Marsh, MD; Senior Associate Vice President for Health Sciences Research, The Ohio State University Medical Center; Vice Dean Research, The Ohio State University College of Medicine; Executive Director, Center for Personalized Health Care, The Ohio State University Medical Center 11:15 a.m.-noon Keynote Speaker: Preventive Medicine and Healthcare Reform Ralph Snyderman, MD; Director of the Center for Research on Prospective Health Care, James B. Duke Professor of Medicine, Chancellor Emeritus, Duke University Noon-1:15 p.m. Lunch 1:15-2:45 p.m. Presentations and Panel Discussion: Advances in the Prevention and Treatment of Cardiovascular Disease Moderator: Ray E. Hershberger, MD; Professor of Medicine, Associate Chief for Division of Cardiology, Director of Advanced Heart Failure Therapies Program and Director for Translational Cardiovascular Genetic Medicine, University of Miami Miller School of Medicine Presenters/Panelists: o Future of Proteomics Jon Klein, MD, PhD; James Graham Brown Chair in Proteomics, University of Louisville o New Physician/Patient Paradigms in the Treatment of Heart Failure William Abraham, MD, FACP, FACC, FAHA; Director, Division of Cardiovascular Medicine, The Ohio State University Medical Center o Pharmacogenetics of Statin Therapies Dan Chasman, PhD; Brigham and Womens Hospital 2:45-3 p.m. Break

3 -5:15 p.m. Presentations and Panel Discussion: Infrastructure to Enable Personalized Medicine Moderator: Edward Abrahams, PhD; President, Personalized Medicine Coalition Presenters/Panelists: o Role of Media in Knowledge Dissemination Michael Millenson; President, Health Quality Advisors LLC o Reducing The Distance Between Data & Knowledge: Realizing the Promise of HIT and Biomedical Informatics Philip Payne, PhD; Associate Professor and Chair, Department of Biomedical Informatics, The Ohio State University; Executive Director in the Center for IT Innovations in Healthcare (CITIH), The Ohio State University Medical Center ; Center Co-Director, Biomedical Informatics Program in the Center for Clinical and Translational Science, The Ohio State University Medical Center; CoDirector, Biomedical Informatics Shared Resource, The Ohio State University Comprehensive Cancer Center o Translating Research into Standard of Care William E. Smoyer, MD, FASN; C. Robert Kidder Chair, Nationwide Childrens Hospital; Director, Center for Clinical and Translational Research, Research Institute at Nationwide Childrens Hospital o Recent Developments in Pharmacogenomics Lawrence Lesko, PhD, FCP; University of Florida College of Pharmacology o Venture Investment and Personalized Medicine Dion Madsen, CFA; Managing Director, Physic Ventures 5:15 -5:20 p.m. Closing Comments for Day 1 Clay Marsh, MD; Senior Associate Vice President for Health Sciences Research, The Ohio State University Medical Center; Vice Dean Research, The Ohio State University College of Medicine; Executive Director, Center for Personalized Health Care, The Ohio State University Medical Center 5:30-7 p.m. Reception 6-6:30 p.m. Keynote Speaker: Community Wellness Eddie George

October 7

8:30-8:40 a.m. Opening Remarks E. Gordon Gee, JD, EdD; President, The Ohio State University 8:40-8:45 a.m. Introduction of Keynote Speaker Clay Marsh, MD; Senior Associate Vice President for Health Sciences Research, The Ohio State University Medical Center; Vice Dean Research, The Ohio State University College of Medicine; Executive Director, Center for Personalized Health Care, The Ohio State University Medical Center 8:45-9:30 a.m. Keynote Speaker: Complex and Adaptive Systems in Health CareMaking the Connections to Patient Engagement Ann Pendleton-Jullian, PhD; Director, Architecture Section and Walter H. Kidd Professor, Austin E. Knowlton School of Architecture, The Ohio State University 9:30-11 a.m. Presentations and Panel Discussion: Creating a Consumer-Focused Environment for Participatory Health Care Moderator: e-Patient Dave deBronkart; Co-Chairman, Society for Participatory Medicine Presenters/Panelists: o Patient Engagement through the Use of IT Milisa Rizer, MD; Clinical Director, EMR, The Ohio State University Medical Center o Encouraging Patient Participation Kathryn Teng, MD, FACP; Director, Center for Personalized Health Care, Cleveland Clinic o Employee Wellness Gretchen Feldmann, MA; Benefits Strategy & Engagement Manager, Office of Human Resources, The Ohio State University 11-11:15 a.m. Break 11:15 -11:50 a.m. Panel Discussion: Ohio as a Center of Healthcare Reform- A CEOs Perspective Moderator: Clay Marsh, MD; Senior Associate Vice President for Health Sciences Research, The Ohio State University Medical Center; Vice Dean Research, The Ohio State University College of Medicine; Executive Director, Center for Personalized Health Care, The Ohio State University Medical Center Panelists:

o Delos M. Toby Cosgrove, MD; CEO and President, Cleveland Clinic o Steven G. Gabbe, MD; Senior Vice President for Health Sciences, The Ohio State University; CEO, The Ohio State University Medical Center 11:50 -11:55 a.m. Introduction of Featured Speaker Clay Marsh, MD; Senior Associate Vice President for Health Sciences Research, The Ohio State University Medical Center; Vice Dean Research, The Ohio State University College of Medicine; Executive Director, Center for Personalized Health Care, The Ohio State University Medical Center 11:55 a.m.-12:25 p.m. Featured Speaker: Market Potential of P4 Medicine Gerald McDougall, PricewaterhouseCoopers 12:25-12:30 p.m. Closing Comments Clay Marsh, MD; Senior Associate Vice President for Health Sciences Research, The Ohio State University Medical Center; Vice Dean Research, The Ohio State University College of Medicine; Executive Director, Center for Personalized Health Care, The Ohio State University Medical Center 12:30 p.m. Program Adjourns