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  • Featured Product of Selleck - GDC-0879 (Purity 99%)

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    Selleck Chem
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    Technical Data: M.Wt: 334.37 Formula: C19H18N4O2 Solubility: DMSO Purity: >99% Storage: at -20℃ 2 years CAS No.: 905281-76-7 Biological Activity of GDC-0879: GDC-0879 is a highly selective, novel potent, orally bioavailable B-Raf inhibitor in various in vitro and cell-based assays with an IC50 estimate of 0.13 nM against purified B-Raf V600E enzyme and a cellular pERK IC50 of 63 nM in the MALME-3M cell line . [1] For this compound, subnanomolar enzyme potency translated into very effective reduction of cellular viability of BRAF-mutant Malme3M cells (EC50 values were 0.75 µmol/L for GDC-0879). [1] In GDC-0879-treated mice, both cell line- and patient-derived BRAFV600E tumors exhibited stronger and more sustained pharmacodynamic inhibition (>90% for 8 hours) and improved survival compared with mutant KRAS-expressing tumors.[2] References on GDC-0879: [1] Klaus P. Hoeflich et al. Cancer Res.2009 April 1;69:3042-3051 [2] Harvey Wong et al. JPET.2009 April;329(1):360-367

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    Featured Product of Selleck---GDC-0879(Purity>99%)

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    Technical Data: M.Wt: 334.37 Formula: C19H18N4O2 Solubility: DMSO Purity: >99% Storage: at -20℃ 2 years CAS No.: 905281-76-7 Biological Activity of GDC-0879: GDC-0879 is a highly selective, novel potent, orally bioavailable B-Raf inhibitor in various in vitro and cell-based assays with an IC50 estimate of 0.13 nM against purified B-Raf V600E enzyme and a cellular pERK IC50 of 63 nM in the MALME-3M cell line . [1] For this compound, subnanomolar enzyme potency translated into very effective reduction of cellular viability of BRAF-mutant Malme3M cells (EC50 values were 0.75 µmol/L for GDC-0879). [1] In GDC-0879-treated mice, both cell line- and patient-derived BRAFV600E tumors exhibited stronger and more sustained pharmacodynamic inhibition (>90% for 8 hours) and improved survival compared with mutant KRAS-expressing tumors.[2] References on GDC-0879: [1] Klaus P. Hoeflich et al. Cancer Res.2009 April 1;69:3042-3051 [2] Harvey Wong et al. JPET.2009 April;329(1):360-367

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    Featured Product of Selleck - GDC-0879 (Purity 99%)

    Uploaded by

    Selleck Chem
    Technical Data: M.Wt: 334.37 Formula: C19H18N4O2 Solubility: DMSO Purity: >99% Storage: at -20℃ 2 years CAS No.: 905281-76-7 Biological Activity of GDC-0879: GDC-0879 is a highly selective, novel potent, orally bioavailable B-Raf inhibitor in various in vitro and cell-based assays with an IC50 estimate of 0.13 nM against purified B-Raf V600E enzyme and a cellular pERK IC50 of 63 nM in the MALME-3M cell line . [1] For this compound, subnanomolar enzyme potency translated into very effective reduction of cellular viability of BRAF-mutant Malme3M cells (EC50 values were 0.75 µmol/L for GDC-0879). [1] In GDC-0879-treated mice, both cell line- and patient-derived BRAFV600E tumors exhibited stronger and more sustained pharmacodynamic inhibition (>90% for 8 hours) and improved survival compared with mutant KRAS-expressing tumors.[2] References on GDC-0879: [1] Klaus P. Hoeflich et al. Cancer Res.2009 April 1;69:3042-3051 [2] Harvey Wong et al. JPET.2009 April;329(1):360-367

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    Product Information

    S1104 GDC-0879
    B-Raf

    Novel Life Science Reagents


    for Cell Signaling Research

    Toll Free:
    (877)796-6397
    -- USA and Canada only --

    Fax:
    +1-713-796-9816

    Technical Data:
    M.Wt: Formula: Solubility: Purity: Storage: CAS No.: 334.37 C19H18N4O2 DMSO 99% at -20 2 years 905281-76-7
    HO N N N OH

    Orders
    +1-713-922-4115 enquiry@selleckchem.com

    Tech Support
    tech@selleckchem.com
    (chemistry support)

    techbio@selleckchem.com
    (bio support)

    Biological Activity
    GDC-0879 is a highly selective, novel potent, orally bioavailable B-Raf inhibitor in various in vitro and cell-based assays with an IC50 estimate of 0.13 nM against purified B-Raf V600E enzyme and a cellular pERK IC50 of 63 nM in the MALME-3M cell line.[1] For this compound, subnanomolar enzyme potency translated into very effective reduction of cellular viability of BRAF-mutant Malme3M cells (EC50 values were 0.75 mol/L for GDC-0879).[1] In GDC-0879-treated mice, both cell line- and patient-derived BRAFV600E tumors exhibited stronger and more sustained pharmacodynamic inhibition (>90% for 8 hours) and improved survival compared with mutant KRAS-expressing tumors.[2]

    Web
    www.selleckchem.com

    Selleck Overnight Delivery Service

    References
    [1] Klaus P. Hoeflich et al. Cancer Res.2009 April 1;69:3042-3051 [2] Harvey Wong et al. JPET.2009 April;329(1):360-367

    Return Policy
    Please inspect packages immediately upon receipt and notify customer service within 3 days of delivery of any damage or discrepancies.Our team will take quick and appropriate action to correct any problem.

    MSDS & CoA


    Please visit www.selleckchem.com to download MSDS and CoA.

    Goods ordered in error can only be accepted for return if made within 3 days of delivery, are unopened,have been stored correctly and are in good condition. Should you wish to return any item(s), prior authorization must

    Notes
    PLEASE KEEP THE PRODUCT UNDER -20 FOR LONG-TERM STORAGE. NOT FOR HUMAN OR VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.
    Specific storage and handling information for each product is indicated on the product datasheet. Most Selleck products, stored under the recommended conditions, are stable for two years. Products are sometimes shipped at a temperature that differs from the recommended storage temperature,most are recommended stored at -20 Many products are stable in the short-term at temperatures that differ from that . required for long-term storage. We ensure that the product is shipped under conditions that will maintain the quality of the product, but save your shipping charges by using the most economical storage conditons for an overnight shipment. Upon receipt of the product, follow the storage recommendations on the product data sheet.

    be received from our customer service team. Returns accepted will be subject to a 30% restocking charge.

    For all product returns and product replacements,please contact Selleck directly by info@selleckchem.com or +1-713-922-4115 Please have on hand, the invoice number, purchase order number,air bill number and approximate date of shipment/receipt.

    Copyright 2010 Selleck chemicals.

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