CAPITOL UNIVERSITY

COLLEGE OF NURSING DRUG CONTRAINDICATIONS ADVERSE EFFECTS OF THE DRUGS Antimalarial Except for its bitter taste,All medicines may cause side chloroquine is usually welleffects, but many people have tolerated. Other mild sideno, or minor, side effects. Inside red blood cells, the malarial parasite must degrade effects, such as nausea andCheck with your doctor if any hemoglobin to acquire essential headache, may be reducedof these most COMMON side amino acids, which the parasite by taking the drug with food.effects persist or become African-Canadians maybothersome when using requires to construct its own experience generalizedChloroquine: protein and for energy pruritus, which is not metabolism. indicative of drug allergy.Appetite loss; clumsiness; Transient, minor visualdiarrhea; dizziness; feeling of Disease-Modifying blurring may occur initiallywhirling motion; mild Antirheumatic Drugs but should not be a reasonheadache; nausea; stomach to discontinue chloroquine.cramps; vomiting. Against rheumatoid arthritis, it operates by inhibiting lymphocyte Retinal toxic effects, which proliferation, phospholipase A, may occur with long-termSeek medical attention right antigen presentation in dendritic daily doses of chloroquineaway if any of these SEVERE cells, release of enzymes from (>100 g total dose) used inside effects occur when using lysosomes, release of reactive the treatment of otherChloroquine: diseases, are extremely oxygen species from unlikely with chloroquineSevere allergic reactions macrophages, and production given as weekly(rash; hives; itching; difficulty chemoprophylaxis. breathing; tightness in the of IL-1. Chloroquine may worsenchest; swelling of the mouth, DRUG STUDY MECHANISM OF ACTION

Chloroquine
DOSAGE:
Dose of Chloroquine (as base) (Each 250 mg tablet contains 150 mg base and Age in each 5 ml of suspension years contains 50 mg base) 1st 2nd 3rd 4th dose* dose dose dose 37.5 37.5 37.5 0-1 75 mg mg mg mg 1-5 150 mg 75 mg 75 mg 75 mg 150 150 150 5-9 300 mg mg mg mg 225 225 225 9-14 450 mg mg mg mg 300 300 300 >14 600 mg mg mg mg

ADMINISTRATION: In emergencies it is commonly

administered parenterally after the operation. Antiviral

psoriasis and, rarely, is associated with seizuresface, lips, or tongue); bizarre and psychosis. Therefore,behavior; change in color or As an antiviral agent, it impedes chloroquine should not beskin or inside of mouth; used in individuals with adiarrhea; difficulty seeing and the completion of the viral life history of epilepsy or reading (words, letters, or cycle by inhibiting some generalized psoriasis. processes occurring within Concurrent use ofparts of objects missing when intracellular organelles and chloroquine interferes withreading); fever or sore throat; requiring a low pH. As for HIV-1, antibody response tohair loss; hearing loss; mood intradermal human diploidchanges; ringing in the ears; chloroquine inhibits the rabies vaccine. seizures; sensitivity to sunlight; glycosylation of the viral unusual bleeding or bruising; envelope glycoprotein gp120, unusual weakness; vision which occurs within the Golgi problems; weight loss. apparatus. Antitumor The mechanisms behind the effects of chloroquine on cancer are currently being investigated. The best-known effects (investigated in clinical and preclinical studies) include radiosensitising effects through lysosome permeabilisation, and chemosensitising effects through inhibition of drug efflux pumps (ATP-binding cassette transporters) or other actions.

Issue: 05 April 2006 Code:003

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