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  • M4 L6 Lead Toxicity

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    Urban EcoLab Curriculum
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    Lead appears to serve NO useful purpose in the human body when It gets into the It seems to interrupt important 1. It inhibits and mimics the of calcium. Takes the place of 2. It interferes with the work of several proteins. Dangerous Amounts Because calcium is an important ion that is associated with many processes that occur in the body like. Brain kidney NO AMOUNT of lead EXPOSURE is SAFE because It disrupts these natural processes.

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    Lead appears to serve NO useful purpose in the human body when It gets into the It seems to interrupt important 1. It inhibits and mimics the of calcium. Takes the place of 2. It interferes with the work of several proteins. Dangerous Amounts Because calcium is an important ion that is associated with many processes that occur in the body like. Brain kidney NO AMOUNT of lead EXPOSURE is SAFE because It disrupts these natural processes.

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    © All Rights Reserved
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    133 views11 pages

    M4 L6 Lead Toxicity

    Uploaded by

    Urban EcoLab Curriculum
    Lead appears to serve NO useful purpose in the human body when It gets into the It seems to interrupt important 1. It inhibits and mimics the of calcium. Takes the place of 2. It interferes with the work of several proteins. Dangerous Amounts Because calcium is an important ion that is associated with many processes that occur in the body like. Brain kidney NO AMOUNT of lead EXPOSURE is SAFE because It disrupts these natural processes.

    Copyright:

    © All Rights Reserved
    Download as PDF, TXT or read online from Scribd
    Flag for inappropriate content
    of 11

    WhyandHowisLeadToxic?

    Module 4 Lesson 6

    This material is based on work supported by the National Science Foundation ("NSF") under Grant No. 0607010. Any opinions, findings, and conclusions or recommendations expressed in this material are those of the authors and do not necessarily reflect the views of the National Science Foundation.

    PhysicalProper7esofLead
    Bluishwhitelustrousmetal Veryso? Malleable Duc7le Rela7velypoorconductorofelectricity

    EverydayUses
    Leadpipes LeadacidcarbaGeries Ceramicglazes Cables Solders Leadcrystalglassware
    http://commons.wikimedia.org/wiki File:Plate_carnations_Iznik_MBA_Lyon_E500-61.jpg http://commons.wikimedia.org/wiki/ File:Arles_loden_buizen.jpg

    Glassofcomputerandtelevisionscreens

    EverydayUses
    PreviouslyusedinU.S: gasoline(priorto1980) paint(bannedin1978,buts7llpresentin olderhousesandimportedproducts)

    http://commons.wikimedia.org/wiki/File:Gas_pump_lead_warningSmall.jpg

    http://commons.wikimedia.org/wiki/File:FEMA_-_20363__Photograph_by_Marvin_Nauman_taken_on_11-29-2005_in_Louisiana.jpg

    HowLeadEnterstheBody andSomeSources
    Inges7on Pes7cidesandfer7lizers Leadpaintchips Water Corrosionofpipesthatcarrydrinkingwater Air Dustfromleadpaint

    WheredoesLeadgoonceitisintheBody?
    Onceinthebloodstream,leadgetsstoredin threebasicplaces: Blood Mineralizing7ssue 95%ofthetotalleadintheadultbodyis foundinbonesandteeth So?Tissues

    WhyisLeadaProblem?
    Leadappearstoservenousefulpurposeinthe humanbody. Whenitdoesgetintothebody,however,it seemstointerruptimportantprocesses: 1. Itinhibitsandmimicstheac7onsof calcium.(Pb2+takestheplaceofCa2+) 2. Itinterfereswiththeworkofseveral proteins.

    DangerousAmounts
    Becausecalciumisanimportantionthatis associatedwithmanyprocessesthatoccurin thebodylike. brainfunc7on kidneyfunc7on fer7lity NOAMOUNTOFLEADEXPOSUREISSAFE becauseitdisruptsthesenaturalprocesses.

    LeadPoisoninginChildren:ABigProblem
    About 310,000 U. S. Children ages 1 to 5 have elevated blood lead levels which can accumulate over months and years and cause serious health problems

    Childrensuerneurologicaleectsatmuchlowerexposure levels. Neurologicaleectsmaybeginatbloodlevelsatorbelow 10g/dLinsomecases,anditmaynotbepossibleto detectthemonclinicalexamina7on.

    LeadPoisoninginChildren:ABigProblem
    Somestudieshavefound,forexample,thatforevery10g/dLincrease
    inbloodleadlevels,childrensIQwasfoundtobelowerbyfourtoseven points(Yuleetal.,1981;Schroederetal.,1985;Fultonetal.,1987; Landsdownetal.1986;Hawketal.1986;Winnekeetal.1990ascitedin AAP1993). ThereisalargebodyofevidencethatassociatesdecrementinIQ performanceandotherneuropsychologicaldefectswithleadexposure ThereisalsoevidencethataGen7ondecithyperac7vitydisorder (ADHD)andhearingimpairmentinchildrenincreasewithincreasingblood leadlevels,andthatleadexposuremaydisruptbalanceandimpair peripheralnervefunc7on(ATSDR2005). Someoftheneurologicaleectsofleadinchildrenmaypersistinto adulthood.

    Preven7onandTreatment
    Thebanonleadedgasolineandpainthave helpedreducetheaveragebloodleadlevels foundinU.S.children. Adietthatishighincalciumisalsothoughtto helppreventleadpoisoning. Whydoyouthinkthisis?

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