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By Kim Niles. (See accompanying article at http://www.isixsigma.com/library/bio/kniles.asp) 2 levels of 3 factors with up to 8 reps = (2^3) x 8 = 64 or less data points; Change only yellow boxes
Factor Assignment
Run Order G=ABC
Quick Calculations
D=AB
1 2 3 4 5 6 7 8
2 3 4 1
A B C - - + - - + + + - - + + - + - + + + + +
+ + + +
+ + + +
+ + + +
+ + + +
R1 100 50 28 46
R2 88 55 21 54
R3 16 18 11 12
R4 22 33 44 55
R5
R6
R7
R8
Run#
E=AC
Factor B
F=BC
26 57
+ +
42 39
+ +
+ +
Factor C
57
+ +
39
+ +
26
+ +
42
Factor B
14 44
+ +
20 17
+ +
+ +
Factor C
44
+ +
17
+ +
14
+ +
20
Factor B
0.3 0.1
+ +
0.3 0.4
+ +
+ +
= 1 / 4 = Ave= = / 4 = Ave= Total Effect = Difference = = / 4 = Ave= = 1 / 4 = Ave= Total Effect = Difference =
Factor C
+ +
0.4
+ +
0.3
+ +
0.3
Calc. the Sig. of 2nd Order Interaction Effects or Aliased Effects (Solving for Means)
Factor D (AB) uns Where D is + : R Runs Where D is - : 57 39 + + 42 26 + + + + = 98 / 4 = Ave= = 65 / 4 = Ave= Total Effect = Difference = = 83 / 4 = Ave= = 81 / 4 = Ave= Total Effect = Difference = = 96 / 4 = Ave= = 68 / 4 = Ave= Total Effect = Difference = 24.56 16.25 8.31 20.63 20.19 0.44 23.88 16.94 6.94
57 39
+ +
26 42
+ +
+ +
57 26
+ +
39 42
+ +
+ +
Calc. the Sig. of 2nd Order Interaction Effects or Aliased Effects (Solving for Std Dev.)
Factor D (AB) uns Where D is + : 43.6 R Runs Where D is - : 16.9 + + 20.2 13.9 + + + + = 64 / 4 = Ave= = 31 / 4 = Ave= Total Effect = Difference = = 58 / 4 = Ave= = 37 / 4 = Ave= Total Effect = Difference = = 61 / 4 = Ave= = 34 / 4 = Ave= Total Effect = Difference = 15.97 7.69 8.28 14.38 9.28 5.10 15.13 8.53 6.60
+ +
13.9 20.2
+ +
+ +
+ +
16.9 20.2
+ +
+ +
Calc. the Sig. of 2nd Order Interaction Effects or Aliased Effects (Solving for Sig-to-Noise)
Factor D (AB) uns Where D is + : R Runs Where D is - : 0.1 0.4 + + 0.3 0.3 + + + + = / 4 = Ave= = 1 / 4 = Ave= Total Effect = Difference = = / 4 = Ave= = 1 / 4 = Ave= Total Effect = Difference = = / 4 = Ave= = 1 / 4 = Ave= Total Effect = Difference = 0.11 0.16 -0.05 0.1 0.17 -0.07 0.12 0.15 -0.03
0.1 0.4
+ +
0.3 0.3
+ +
+ +
0.1 0.3
+ +
0.4 0.3
+ +
+ +
Calc. the Sig. of 3rd Order Interaction Effects, Error, or Aliased Effects (Solving for Means)
Factor G (ABC) Where G is + : Runs Runs Where G is - : 39 57 + + 26 42 + + + + = 65 / 4 = Ave= = 98 / 4 = Ave= Total Effect = Difference = 16.25 24.56 -8.31
Calc. the Sig. of 3rd Order Interaction Effects, Error, or Aliased Effects (Solving for Std.Dev.)
+ +
16.9 20.2
+ +
+ +
Calc. the Sig. of 3rd Order Interaction Effects, Error, or Aliased Effects (Solving for Sig.-to-Noise)
Factor G (ABC) Where G is + : Runs Runs Where G is - : 0.4 0.1 + + 0.3 0.3 + + + + = 1 / 4 = Ave= = / 4 = Ave= Total Effect = Difference = 0.16 0.11 0.05
Calculating Confidence
ANOVA analysis is used to compare "within variation" with "between variation". Hypotheses: Ho= All means are equal; HA= They are not equal Linear contrasts is a method used to test any two levels or combinations of two levels against each other. Degrees of freedom is always 1 for testing two items. Calculating the Grand Average Row Number: 1 2 3 4 Row Averages: 56.5 39.0 26.0 41.8
5 -
6 -
7 -
8 -
Factor Sum of Squares (Linear Contrast Effect)^2/((1/n low level)+ (1/n high level)); n = number of data points Factor A = -0.4 ^2 / (1/2) = 0.4 Factor B = -6.9 ^2 / (1/2) = 96.3 Factor C = -40.8 ^2 / (1/2) = ### Factor D (AB) = 8.3 ^2 / (1/2) = 138.2 Factor E (AC) = 0.4 ^2 / (1/2) = 0.4 Factor F (BC) = 6.9 ^2 / (1/2) = 96.3 Factor G (ABC) = -8.3 ^2 / (1/2) = 138.2
Total Sum of Squares Row Number: 1 2 3 4 Row Averages: 56.5 39.0 26.0 41.8 GA - Row Average: -15.7 1.8 14.8 -0.9 (GA - Row Average)^2: 246.1 3.3 ### 0.9
5 -
ANOVA Table Is there a statistically significant difference between factors, rows, and error? Df = Degrees of freedom MS = Mean Sum of Squares SS = Sum of Squares F = F-test characteristic Alpha = F-test probability SS Factor A Factor B Factor D (AB) Factor E (AC)
0.4 96.3
Df
1 1 1 1 1 1 1 7
MS
0.38 96.26
F
0.00 0.70
Alpha Conf.
0.967 0.557 0.128 0.500 0.967 0.557 3% 44% 87% 50% 3% 44%
confidence that this is significant confidence that this is significant confidence that this is significant confidence that this is significant confidence that this is significant confidence that this is significant
Factor C 3331.3
138.2 0.4
Additional Comments
Note #1: If the data is known to be normally distributed, analyzing the within run data as design replicates yields higher confidence in the results. Unfortunately this matrix is not set up to do that. Note #2: Error in the results increases as columns contain greater amounts of partial data. For example, if two reps are taken for each run, then columns R1 and R2 should be fully filled out.
P (
A + + + +
1 2 3 4
B + + -
+ + -
+ + -