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> Girls (2:1) Genetics: ITPKC gene (inositol-trisphosphate 3-kinase C) Modifiable Factors Environment: Exposure to virus or bacteria
RACE Asian
GENDER Male
GENETIC S ITPKC
Idiopathic
B-cells activation
Eyes
Mucosa
Finger gangrene
Attracts and activates more B-cells, cytotoxic Tcells, Natural killer cells, Macrophages and other cells in immune system
Lymphokine Production
Skin
Red palms and soles of the feet Non-vesicle-bullous, non-itchy, non-specific, polymorphic rash in the trunk
Musculoskeletal
(+) Pain
Aneurysm Stagnant blood flow, activated platelets, inflammed endothelium
CVS
Thrombotic occlusion
Localized stenosis
MI, Embolism