NIPER -2006 (QUESTION PAPER)

NOTE: - The paper is not the clone of original paper, but it has been prepared by us after coming out of exam hall by recalling the questions, and by help of many students. Some questions are reproduced as they are and some in fragments. The main objective behind this work of preparing this rough format is to pass the information about the exam to the next aspirants of NIPER, as the syllabus of the exam is not declared. The word in bracket indicates answer for that question. Time- 2 hr. 100 Qutions-200. Format-objective type (with 4 options) Answers-to be marked on ORS SHEET with HB pencil. MarksNegative marking-@25%

1. Mode of action of taxol 2. Cyclodextrin (which form is more soluble) 3. Bigesst cotton producing country. 4. Alanine configuration(R or S) 5. Correct structure of nifedipine 6. Which amongst following is Ca channel blocker. 7. Glutathione is (ans-tripeptide and detoxifing agent) 8. Polypharmacy means9. Phenytoin therapeutic use 10. Propranolol contradicted in11. Which amongst following undergo more first pass metabolism (propranolol, digitalis, aspirin). 12. Calculate %age yield (given therotical and practical yield) 13. Term 'IPEP' is related with14. Paracetamol (toxic metabolite) 15. Benzyl alcohol in parenteral concentration (how much?) 16. Area of rectangle (given length, bredth in terms of length) 17. Interest calculation 18. Deadly organism of malaria (Plasmodium Falcipuram) 19. Which of following is cardiotoxic. 20. Antonym of solisitarious21. Synonym of macabre 22. Coumarin ring system-scientific name 23. Ca channels in heart are of which type (ans-voltage gated) 24. Receptors are (protein in nature) 25. Serotonin-is (ans neurotransmitter) 26. Second messenger system calcium - cAMP - cGMP - all the above. 28. In cough syrup alkaloid present (ans-codeine) 29. Aspirin MOA 30. Drug for alopecia (Minoxidil) 31. Protogenic solvent water - acetic acid - CCl 4 - None.

32. Which one is optically active eg. allens 33. Enalapril 34. Drug used in Parkinsonism 35. Tretment agent for cerebral malaria 36. Primaquin use (specific) 37. Intestinal amoebiasis causative agent. 38. Dopamine agonist- (Bromocriptine) 39. ACE inhibitors side effect. 40. Statins use- (Hypolipidemic agents) 41. Prostaglandin synthesis which enzymes involved. 42. Rifampicin use other than T.B. 43. L-threose and L-erythrose are 44. Marine anticancer drug 45. Fermentation-batch process 46. Which of following is not static dryer? (Tunnel dryer) 47. Podophyllotoxin is (lignan) 48. Betain-structure 49. Gene _expression is done by(transcription) 50. DNA is present in51. Ring analogues of sugar are called (anomers) 52. Crystallization of sugar in syrup is avoided by addition of - Alcohol - Lemon juice 53. Application of head space analysis 54. Bacterial cell wall constitution 55. Cellular structure is identified by (phase contrast microscopy) - Electron Microscopy - Phase contrast Microscopy - Dark Field Microscopy - None 56. Metals and metalloids are identified by which spectroscopy57. Phosphorescence and fluorescence (emission spectroscopy) 58. Energy wise order-UV, IR, NMR 59. Spectroscopy for detection of hydrogen bonding (IR) 60. COCl- IR stretching range 61 Lactum rings- IR stretching range 62 Fluid energy mill- particle size? (10-30 m) 63. If pKa of drug is 5.4 maximum absorption will occur from- Stomach - Duodenum - Small intestine - Large intestine 64. Morphine mainly acts on ( receptor) - receptor - and delta receptor -delta and kappa receptor

-kappa receptor

65. Anti acetylcholine used in peptic ulcer66. Metachlopromide-MOA 67 Agent used in treatment of anticancer agent induced emesis (ondencetron) 68 Gallic acid is-antioxidant, preservative,,none of the above. 69. Eye drops differ from parenteral preparation (pyrogenicity) - Sterility - Particulate matter - Pyrogenicity - Isotonicity 70. Agent used in treatment of acute gout. (colchicin) 71 000 capsule capacity in mg. 72. Green bones are used for preparation of which type of gelatin. 73. HIV is caused by 74. Name of scientist-meningitis discovery 75. Equation related with osmosis 76 If hour hand of a clock at 12noon is at north east, then at 1pm where will be the hour hand of the clock-----east, west, north, south? 77. Dipole moment in 1,2-dibromoethane 78. B.S of Indian Ginseng 79. Alzheimer's disease is (neuro degenerative disease) 80. CVS drug- which neutraceutical 81. Circular dichroismapplication 82. Absorptivity or extinction coefficient depends upon--83. In mono substituted cyclohexane, which form is stable axial, equatorial 84. Tamoxifen is (estrogen antagonist) 85. Triterpines are prepared from (six isoprene unit) 86. Terpenes biosynthetic pathway 87. Indole alkaloids r biosynthesized from (Tryptophan) 88. Modern chemotherapy was discovered by 89. Bacteria r present in following except------- ice, sea water, distilled water, soil 90. Submerged culture is difficult for which micro organism. 91. Mammalian cell gene _expression is done by (protein synthesis) 92. Which packaging material is more water vapour permeable? 93 Vehicle for soft gelatin capsule 94. Material used for packaging during Accelerated stability studies. 95. Polymers are added to amorphous substances for what? 96. HLB range of w/o emulsion 97. Which of the following is directly titrated with acid---------- Aminophyllin, - Phenytoin, - Sulphynpyrazone, - Phenobarbitone.

98. Formula for angle of repose 99. ABC concept is used for (Inventory Control) 100. Liposomes are used to solubilize 101. Nujol is (mineral oil) 102. Detector used in IR 103. IR source 104. Range of UV-visible light 105. Reference substance used in NMR 106. Diosgenin has which basic nucleus? 107. When IND is applied? 108. When phase IV clinical trials are started 109. Enthalpy is (heat content) 110. Kinetics is study of -----rate, order, molecular, none of above 111. Which one is optically activecrystal, molecule----112. Structure of antibody 113. Which one is reducing sugar (sucrose) 114. Endogenous anticoagulant (heparin) 115. Insulin is secreted by 116. Omeprazole MOA 117. pH of 0.05 M HCl is 118. Metronidazole use 119. Different polymorphs differ in which properties 120. Albuterol MOA 121. Salmeterol which class 122. Selective alpha 1 receptor antagonist (Prazosin) 123. Fatal Adverse effect is of which combination - Terfenedine + loratidine - Terfenedine + erythromycin 124. Dissolution test apparatus for tablets - USP I/ II 125. Calibration of IR solvent used? 127. What will happen when heat is increased for exothermic reaction? (reaction will shift to which side?) 128. For spontaneous reaction free energy is- ----- +ve , ve 129. Mass spectroscopy--- Base peak? 130. Splitting in 1,4 dioxane 131. Carbonic unhydrase inhibirors (Acetazolamide) 132. Phenolphthalein is... (acid base indicator) 133. Microvilli in intestine ---the function is. 134. RS is what as per IP 135. 1, 3 cyclohexane which form is optically active? 136. HPLC ---widely used (Reversed phase) 137. Size exclusion chromatography use.. 138. A + B = 102; A B = 24 what is A 139. 1:9:17:33:49:73:? 140. Delirium tremors which drug is used

141. Which color pigment present in tomato (lycopene) 142. Which vitamin in high dose causes teratogenicity? (Vit. A) 143. Cytokines are (proteins) 144. NMR signal is expressed in (ppm) 145. Nuclear receptor 146. 2 amide bonds are present in (tripeptide) 147. What causes serine hydrolysis? 148. Non aqueous system binder used? (Ethyl Cellulose) 149. Saffron is cultivated in which state? (Kashmir) 150. Welfare state means. 151. Back titration is done for . 152. Sparingly soluble means(30 to 100 parts) 153. Which polymer is more permeable to water- vapour? 154. Terfenedine side effect? 155. Myasthenia Gravis is caused due to.. 156. Nicotinic receptors are (ligand gated) 157. Number of double bonds are determined by - H2 - Br 2 - Ozonolysis - all the above 158. The compounds which are not detected by UV detector are detected by - Derivitization - Mass spectrometry - Electrochemical detector - all the above 159. Neostigmine does not cross BBB because it is (polar) 160. Which drugs cross BBB? (lipophilic) 161. Effect of Muscarinic drugs on Gastric secretion. 162. Which of the following port has free trade? - Cochin - Madras - Kalanda - Tutikotin 163. Hemoglobin carries ------- Oxygen - Co 2 - Oxygen and Co 2. - None of the above 164. Significance of iodine value 165. t-RNA structural component 166. Carbene is formed in which reaction? (E 1 CB) 167. What is Bredt rule? 168. Polymer's role 169. Which of the following inhibits enzyme induction? 170. CH3Cl in NMR what is effect of Cl? (causes deshielding and down filled effect) 171. Auxochrome enhances(absorption)