You are on page 1of 89

T TColin Campell phD

M Thomas M Campell

20

TT.Colin Campbell
40

20

17

:
1.

2. ( 87%)

3.

4. 15% 16%

5.
6.
7.
8.

9. ()
10.

11.
12.()
13.

14.
3

15.90% 95%
16.
17.

18.
19.

20.

21.
22.
23.
24.
25.
26.
27.()()

28.

29.

30.

31.

32. 5% 6%()
33.

34.

35.

36.
37.

38.
39.

40.
41.

42.


20


(T. Colin Campbell) 1980

20

(Richard Peto)
1983 1989 24
69

Thomas Campbell

2006 9 1

Oprah Winfrey

2005

243
2000 50000

6
M&M

50

-3

40
27

750

2/3 1500
30 20 70

1/3

40

245T

10
110

20
20
5 20
5%
1000

27

87

8000
10

8000

50

30

40

460-357
1946
11

12

430

45 45

17 1963 61 70

47
381
11 30

12 2
1/3 20 3
1/3 3

13

13:()?
()()50153521645417456185581975102096022162233
1 =12 =03048 1 =04536
4

12

19901998 5
3039 70% 4049 40% 5059 31%
534% 6
7980

10 30
70 30 1

1000
8 30
30
910

JAMA

225400 1511
1412
14 12
710760 553091 11225400
167661 122009 97900 69301
65313 49558
1.5 11
137400 1412000
1120000 1180000 15106000
15
16
10 15 39 7
15 1
15

15 1
15

13

16
1997 1 17
2030
1 6 17 7
1 17 40 GDP
300

16 12
19
12
11
37 20

4400 21

20 70
60

14

20 1988

A
E

2400

2223
15

24
800 25-27
2829

170 30-33

1983
27 60

74
35 74
350
1998
1998 25 2004
40

25

16

68


3435
100

20

45

1839
proteios
19 100


17

18311908
485 118

20 1854
1932 WO18441907

USDA
125 55

19

20

15 20

18

100

19581961
23

10
60 70
4
19


145

1976
5

INCAPARINA


6 1970

M
4

4

1973
1

1965

1967

20

79
1011

54 5

1 2 3 3
65 100
65
1520 3 6 3

3 11 14

NIH

29
300

12

10
21

40
4

13
20
5 20
5
100 0

51

22

1990 1950

65 130 6500

8000

23

100

5
95 95
95
99 99

(metanalysis)

100

NRDC
160 1989 2
NRDC CBS 60
23

2 5 51989 6
3

24


1959
DDT

2


FDA

20 70

20 20 6

1970 7
17
8

(NSAR)20
NSAR
35 911
NSAR

NSAR

27 912
30 NSAR
NSAR
NSAR
NSAR NSAR
NSAR
25


NSAR

1970

13/
14
3
1978
1979 15
102 54

5 10

100
0 NSAR

16

20
5

NIH

26

NIH 19

100

()

DNA
31
DNA

27

MFO

3218 18-21

22?
DNA DNA
DNA
DNA
33-DNA 23

DNA

24-26
18
27
2829
-DNA 2330

28

10
35
31

32

33
34 34 20
5
3334

3.5 5
20

35
12 20 5
12 4 3 13 46

2020-20

20-20-5 20
20-20-5-20
20 5
20-5
29

2020-5-20

3536

5 9 20

4%24
3637 10 10
Fumiyiki Horio
38

39

4041
RDA 10

10
10 15%
16
10 5060
15%16 70-100

100 12 15 100
5 100 13 1

10
20510
3734
20
5

30

87

3842
20
20

3643
100
20 100
3643 5
100 0
16
36 40 60

3540

39A3643

10%-20%

31

4445 HBV
20
40
46

4748 3.1047
22
D 14C
6B A

31147
22 6

4951

DBMA NMU

32


DNA

52

5253 5455

1980

33

20 80

20 70

2400 8 8
96 12
65
41
1

2-4
4.2 87

42
35-72135-491 0-750-26 1-4350-286 6-3862-141
7-2483-67 2-672-61 3-590-26 0-20*/10 /

1981 2%
3 4

100 2 3

3000 5

10%20

100 10000

34

50
6 367
65 6500

65

90%94
8000

15%16 80
9%10 10
43
43
/726411989 %14534-38 /
3312 /6491 %0810-11 /3418
43 65 143

77 2400 77
35

3000

4.2
2 - 9
3 6 5

20

48

9
10
44
44

36

44

95
99 999
9511
95 20 19 99
100 99 999
1000 999

127 /
100 215 /12
94 /
80 /

170 /290 /
150 /
37

85

170 / 90 /

(LDL)(HDL)

170 /

17 13
5
CHD
19731975 CHD 24 6
18 1 14

150 /

45

15-18

45
-
B
B2B3

38


71 70
7

15

40

-3, -6
DHA ?

40

35%40 19 19

20
20-23 30
39

30 20

30
30
46
46
100% 67% 64% 61% 54%
42% 35% 26% 14% 8% 5% 5% 4%
35%1%
24
9025

1982

30
26
30
1982

202728

29
4.7
330
3132

23 4

47

48
49
1983
145 36
70%
40

8433 93 25

6%24

30 25%30

24 6

135
25 15 19
17 11
34

34 910
3536
3544
4564

37
38

75
30%40
1/5

41

10

39

1993

3 40 410

35 45

42

34 / 18 /

200 18 19

1982

20

43

-
C
E

C - C
E
C
C 42 C
C
C C

NOVA
C
43
58 C
C
- -
- E

44 E

45
E-
C -

C -
44

20

461997
1970 13 526 656

47 51 48 41
6 20 47

2250 49
1450 35
35 50
1450

24 28
6426 6321 4
101 1 47

4753 5347
51

51 5253

45

54
55

30 56 30

57

99

1996 42
10 46 1996
46

1996 32 46

46

50

30 20 4.11

50 10 10
5 50
50

47

50 58

59
60
59

61
90

48

IA

62

12%13
02%-3

49

200300 /

150 /20 70
260 /

70-170 /

15 68

25 30
45

50

51

30 1

4 4 2 24
3000 2 2001 911

403
100 4

8 56

1950
6 25
3 1953 7
30000
300
22
773
7
773

20 1 907

52

10

910
50
11

110
910
50%
1112

13 4

14

17
1948
5000

1000

53

1961

244 /CHD 210


/ 3 15

15

300
2
50

60

1959 20
5.116

17
17 18

1920

20

54

21


/

1946

22 50
50

2 2 22

22
8
12 24 28 56
25 12 19
3822

52
1946

4 23

20
55 59 5316

24

55

25
30 50

1960
26

B6

NCAA
37
198

20 50

56

50

4
1950
582 58
1970 65
38 15
2
2728

24 2000
2
29 20 70 2

1990 38 30 750

46000 32 50 1
31

79
7 33
70%80
34
1/3 35
36
12 12

16 1
37
40
57

38

50

50

20 40 50
20 50 60

30 39

20

B
1956

100 B
19941995 40

11 100

3/4
41

42

58

4243
1985
150 / 5

42
5
2 5 18 18
8 18 49

4243
18 246
/ 132 / 150 /
43LDL
43
11 18
2

70
11 X 11
5 7
7 3044
5

742
44

32
89 /
5.48
A

5 5 1995 5
10 42 2003 17 18
1 17 7080 45

490 49
59


55

15

28 46 20

28

10

46

1 3
2 4
46

227 / 172 /
152 / 95 /

44
4
82

91
165

846

60

1993 1998 40
32
1998 200 65
60
32
100
322002 780
2 31000
46000 32 7000
30000
32

47

30 7
200 / 4849
200 /
35 150200 /
50 150 /
10

180190 /
51

49

200 / 30

61


46

B 8

20

2/3 1/3

121
=kgm2
Body Mas
s Index, BMIBMI (kg)(m2)
BMI 25 BMI 30
61

15
16 19 152

9 10 1
3
62

4
2/3 1/3

1999 700 52002


3 1000 6
300 400 5

40
500

20

63

5 30 7-13

17 14
4500

55%15

12 25 16
3 10 1718
12 16 19
1 24 20

21

21500 5
5

64

22

? 9
4 2223

112425

24 11

26
27 24

28

28
15 45 11-18
100-800 2930

20% 5%
5%

5% 20%
65

5% 20%
5%
20% 2 31 5%
20%

3233

3436



1990 1998 8
3318 15
1600 1/3
2
40
15
350 3

510 90%-95
40 2 45
4
4

66

2-4

2-4

70


1999 10

60%-70

60

67

1300 2

100

70 HP 6

20 7.15
10
204 29

30

6
11
7
7

90/

8
89
8

10
4

10
68

4 10

1300

11
25 2 50

12
19401950

1950
13
36000 6
6 1100
14

25 25
15 50


40
3015


25
24
15
21 35
69

8 8 15 7.2

14
3216 73
206 / 141 /

4 17

40 26 34
18
19

9
2 2011

21

2223 3234
22

7
58 31

58
23

75 70
1-2
20

15 350


70

1998

45 9

BRCA-1

BRCA-1 BRCA-2

20-30

71

4 8.1

82
81

1
25-3 2
3
4,5 6,7 67
8-12
3,13-18
19
17%
20 26%63% 8-9
32122

23,24
3%24
25

1994 BRCA-1 BRCA-2 26-29


72

BRCA-1 BRCA-2 30,31

BRCA-1 BRCA-2
02 500 1 BRCA-1 BRCA-2 25
BRCA-1 BRCA-2 32,33
32
BRCA-1BRCA-2

31 22 BRCA-1 BRCA-2
BRCA-1
65 39 BRCA-2
45 11

BRCA-1 BRCA-2

BRCA X
BRCA
34-36
X

5 37

5
5
38

BRCA
/
39,40
4
49%41
42

4344

42

45,46

73


4,5

47 8-10
7 20%-30%
50%47

28
150 /

48,49
50 51 <BR

PCBs

90-95

52 PAHsPAHs
PCBs
PAHs PAHs PAHs
PAHs DNA
DNA
BRCA-1 BRCA-2 53

PAHs DNA
PAH DNA

54 PAH-DNA
PAHs DNA PAHs
74

PAH-DNA
PAHs 54 PAHs
PAHs
DNA
: PCBs
55

HRT

56

56
WHI57
/HERS585 2
WHI 26HERS 3059

56 WHI
10000 7 8 8
57
10000
6 5 57



40 15 60
15

75

2002 6 W 2

60 6 37
70 10
61

10
3419 10 063 62,63
83

64

64

30 32
65
84 23
65

66
7
10 3367
10 10

25

68
76

69 70
66

711990 60

4371
52

71 1990
1992 13
72 4772
13
1/37213
EPIC 51 9
73 20 20
42 34
13 73

17 74

75

85 77 /
25 / 115 / 71 /
408 / 211 /
76


77

77-79
77-82

83,84

84

8385

86

87

20 17
64

88,89

759089,90
89,91 50 10
40

78

92

1389
10-3089

25%9370
94
7% 5 95

PSA
PSA 4
PSA 4
PSA 6

PSA

2001 96
14 - 12 - 9 7

2 4 96

79

2 4
1998

-
23
6

97

91
1.
2.
3.
4.
5.
6.
7.
8.
9.
10.
11.
12./
13.
14.
15.
16.
17.
25 40 12
27 3% 31 1
850 1200
1300 3
912 9 97%2
(MS)I
2
91 4 4 3
5
2
80

3,6,7
2
8
1922 9
100 10

B B

T T

B T

81

11

12-14

82

1992 12
4-12
BSABSA

142 BSA
355 79 BSA 355
BSA

12 15-17
13,18,19
BSA
BSA 18

10 BSA
13,19
20,21 22
19
23
(
) 131

113 2411-13
3 4
10 11-13
25-3
9218
11-13
?

13%-33% 13,20,21,25,26

100 13%-33%

93 93
12 27 14
28
36 29
27

30-32
83


3%
33

3%

50% 60%
15-16 34

1994
19

20 80 15
20 90 35 5-6
36 35 3-4
-
-
37

38
(-) 38

84

1/64

38
38
52 20 20
19

38

(MS)

10
15
39 40
20 40 3

40-42
85

20 40
43

43
100 10
7 44
45,46

43

144
34 47

20 20
16
10

1990 47
95% 30
5% 80%
MS 144
94
34

50 48 40
49,50,47
42,51,52

52
51 95 24 26
52

51
52,53

54
-3 55
86

95

131956

57,58
59
3
25

1/460

9,10,61

62-65
66
87

5
63
67

51

D
() 6,768
D
D
D
D D D

D D T T
D
T T T 69,70
D C D

71

40

88

30

89

You might also like