PATOFISIOLOGI DAN

INTERPRETASI DATA
KLINIK I

DYAH ARYANI PERWITASARI, M.Si, Apt

 Silabi

See silabi

Mid term examination 50%

Examination 50 %

Literatures
1. Price and Wilson, 1992, Patofisiologi, EGC
2. Jones and Rospon, 2003, Patient assesment in
Pharmacy Practice, Lipincott Williams and
Wilkins
3. Frizzel, 2001, Handbook of pathophysiology,
Springhouse corporation (e book)
Pengantar Patofisiologi dan IDK

Normal condition in people is different to
each other.

It happened because of the differencies of
genetic, enviromental interaction,
physiological parameters.

Example : Blood glucose
 Disease and Illness concept

Both are used interchangeably, but not the same

Illness definition : change of individual cause the
person was no longer in the state of perceived
“normal” health.

Illness refers to subjective symptom that may
not indicate the presence of disease.

Disease : occurs when homeostasis isn’t
maintained.

Personal perception about disease was related
with body failure to do the dayli living activity.

Example : someone with diabetes disease.
 Disease

Disease doesn’t represent the new
development of life but express the
distorsion of individual’s normally life.
 Etiology

Definition : the cause of a disease

Intrinsic and extrinsic factor

Intrinsic : inheritance, age, gender, nutritional
status

Extrinsic : enviroment

Idhiopatic : unknown causal

Example : What is etiology of tuberculosis?

Intrinsic factor? Extrinsic factor ?
 Pathogenesis

Definition : a disease’s development or
evolution

Most disease progress are according to a
typical pattern of symptom

Some disease are self limiting disease

Other diseases are chronic disease , may
undergo remissions or exacerbations

Other diseases are never resolve
 Manifestations

Definition : a change in metabolism or cell division that
causes signs, lab data interpretation and symptoms.

Subclinic condition

Subjective : Symptoms, reported by patient

Objective : Signs, disease’s identification by clinicians

Lesi : structural change is caused by disease progress

Sequele : result of inflammation process

Complication : new process or condition caused
secondary by first or original disease.

Resolution : Patient can resolve from the disease without
complication or sequele.
 What is this?

Nausea

Fever

Sskin inflammation

Bacterial pneumonia

Disease is a dynamic process not a static
process

Manifestation of the disease was vary
every time.
 Disease stages
Exposure or injury target tissue is exposed by causative
agent or injury

Latency or incubation period no sign or symptoms are evident

Prodromal period signs and symptoms are mild and non

specific
Acute phase the disease reaches full intensity,
possibly resulting complications
Remission second latent phase occurs in some
disease, is often followed by another
acute phase
Convalescence the patient progresses toward recovery
after the termination of the disease
Recovery the patients regains health or normal
function
 Stress and disease

When a stressor such as life change occurs, a
person can respond in 2 ways :
1. Succesfully to adapt
2. Failure to adapt, it can cause disease
Stress can cause the release of epinephrine and
glucocorticoids, the release of epinephrine can
cause panic or agression.
Disease relate with stress : heart, brain, lung. The
energy of these organs were redirect by stress
respon.