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Biochemistry)
First Semester 2006
Full Marks: 100
Subject: Chem 112 (Organic Chemistry) Pass Marks: 45
Time: 3 hours
Candidates are required to give their answers in their own words as far as practicable. The figure in
the margin indicates full marks.
Group (A) Long Questions (Any three) ×14 = 42)
(3×
1. Discuss SN2 reaction with reference to mechanism, stereochemistry and reactivity.
2. Explain the kinetic and non-kinetic methods of determining reaction mechanism
giving examples.
3. a. Give suitable examples to show the difference between configuration and
conformation. The specification of configuration (R or S) is based on a set of
sequence rules. Justify this statement with appropriate examples.
b. The concentration of cholesterol dissolved in chloroform is 6.15 g per 100 ml of
solution. A portion of this solution in a 5 cm Polarimeter tube causes an observed
rotation of -1.20. Calculate the specific rotation of cholesterol.
4. Outline the preparation of alcohols by following methods by suitable mechanism.
a) Oxymercuration – demercuration
b) Hydrolysis of alkyl halides
c) Hydroxylation of alkenes
d) Hydroboration - oxidation