ibuprofen naproxen ketoprofen diclofenac

ethanol ibuprofen has its toxicity increased by alcohol naproxen has its toxicity increased by alcohol ketoprofen has its toxicity increased by alcohol diclofenac has its toxicity increased by alcohol ethanol No known interaction No known interaction No known interaction ethanol No known interaction

methotrexate Azathioprine Cyclophosphamide

Hydroxychloroquine

methyprednisolone ibuprofen ibuprofen causes additive toxicity with methylprednisolone naproxen causes additive toxicity with methylprednisolone ketoprofen causes additive toxicity with methylprednisolone diclofenac causes additive toxicity with methylprednisolone

prednisolone ibuprofen causes additive toxicity with prednisolone naproxen causes additive toxicity with prednisolone ketoprofen causes additive toxicity with prednisolone diclofenac causes additive toxicity with prednisolone

prednisone ibuprofen causes additive toxicity with prednisone naproxen causes additive toxicity with prednisone ketoprofen causes additive toxicity with prednisone diclofenac causes additive toxicity with prednisone

naproxen

Ketoprofen

diclofenac

The combined use of ORAL corticosteroids and nonsteroidal anti-inflammatory drugs (NSAIDs) mayincrease the potential for serious gastrointestinal (GI) toxicity, including inflammation, bleeding, ulceration, and perforation. During concomitant therapy, patients should be advised to take the medications with food and to immediately report signs and symptoms of GI ulceration and bleeding. methotrexate ibuprofen ibuprofen increases toxicity of methotrexate Azathioprine No known interaction Cyclophosphamide No known interaction

naproxen

naproxen increases toxicity of methotrexate ketoprofen increases toxicity of methotrexate diclofenac increases toxicity of methotrexate

No known interaction

No known interaction

Ketoprofen

No known interaction

No known interaction

diclofenac

No known interaction

No known interaction

Unexpectedly severe and sometimes fatal bone marrow suppression, aplastic anemia, gastrointestinal toxicity, and nephrotoxicity have been reported during concomitant administration of methotrexate with NSAIDs. The risk is greatest in patients receiving high dosages of methotrexate and those with renal impairment.

Hydroxychloroquine ibuprofen naproxen Ketoprofen diclofenac No known interaction No known interaction No known interaction No known interaction Hydroxychloroquine methyprednisolone prednisolone prednisone No known interaction No known interaction No known interaction Hydroxychloroquine methotrexate Azathioprine Cyclophosphamide No known interaction No known interaction No known interaction