Sent: Thursday, March 25, 2004 10:56 AM

Subject: [habitosaludable] Alcohol Consumption and Cardiovascular =

Disease

>Alcohol Consumption and Cardiovascular Disease Mortality in =

Hypertensive Men
>Maciej K. Malinski, MD; Howard D. Sesso, ScD, MPH; Francisco =
Lopez-Jimenez, MD, MSc; Julie E. Buring, ScD; J. Michael Gaziano, MD, =
MPH
>
>Arch Intern Med. 2004;164:623-628.
>
>Background Heavy alcohol drinking is associated with a dose-dependent =
increase in blood pressure, but data on the relation between alcohol =
consumption and mortality in hypertensive patients are sparse.
>
>Objective To assess the relation between light to moderate alcohol =
consumption and total mortality from cardiovascular disease (CVD) among =
men with hypertension.
>
>Participants and Design From the Physicians' Health Study enrollment =
cohort of 88 882 men who provided self-reported information on alcohol =
intake, we identified a group of 14 125 men with a history of current or =
past treatment for hypertension who were free of myocardial infarction, =
stroke, cancer, or liver disease at baseline.
>
>Main Outcome Measure Comparison of total and CVD mortality among men =
with hypertension who had reported to be either nondrinkers or rare =
drinkers, or light to moderate drinkers.
>
>Results During 75 710 person-years of follow-up, there were 1018 =
deaths, including 579 from CVD. Compared with individuals who rarely or =
never drank alcoholic beverages, those who reported monthly, weekly, and =
daily alcohol consumption, respectively, had multivariate adjusted =
relative risks (RRs) for CVD mortality of 0.83 (95% confidence interval =
[CI], 0.62-1.13), 0.61 (CI, 0.49-0.77), and 0.56 (CI, 0.44-0.71) (P<.001 =
for linear trend). In the same groups, RRs for total mortality were =
respectively 0.86 (CI, 0.67-1.10), 0.72 (CI, 0.60-0.86), and 0.73 (CI, =
0.61-0.87) (P<.001 for linear trend). Among men with a systolic blood =
pressure of 140 mm Hg or higher or a diastolic blood pressure of 90 mm =
Hg or higher, the RRs for CVD mortality were, respectively, 1.00 =
(referent), 0.82 (CI, 0.56-1.21), 0.64 (CI, 0.48-0.85), and 0.56 (CI, =
0.42-0.75) (P<.001 for linear trend). On the other hand, we found no =
significant association between moderate alcohol consumption and cancer =
mortality (P = .8 for linear trend).
>
>Conclusion These results, which require confirmation in other =
large-scale studies, suggest that light to moderate alcohol consumption =
is associated with a reduction in risk of total and CVD mortality in =
hypertensive men.
From St Vincent Hospital, Worcester Medical Center, University of =
Massachusetts Medical School, Worcester (Dr Malinski); the Divisions of =
Preventive Medicine (Drs Sesso, Buring, and Gaziano), Aging (Drs Sesso =
and Gaziano), and Cardiology (Dr Gaziano), Brigham and Women's Hospital, =
Boston, Mass; the Department of Epidemiology, Harvard School of Public =
Health, Boston (Drs Sesso and Buring); the Massachusetts Veterans =
Epidemiology Research and Information Center, VA Boston Healthcare =
System, Boston (Drs Sesso and Gaziano); and the Cardiovascular Division, =
Mayo Clinic and Mayo Foundation, Rochester, Minn (Dr Lopez-Jimenez). The =
authors have no relevant financial interest in this article.
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