Drug Study Brand Name: Erceflora Classification: Antidiarrheals Suggested Dose: Adults 2-3 vials of 2 billion/5 mL susp Children

2-11 years 1-2 vials of 2 billion/5 mL susp Infants >1 month 1-2 vials of 2 billion/5 mL susp. Mode of Action: Contributes to the recovery of the intestinal microbial flora altered during the course of microbial disorders of diverse origin. It produces various vitamins, particularly group B vitamins thus contributing to correction of vitamin disorders caused by antibiotics & chemotherapeutic agents. Promotes normalization of intestinal flora. Indication: Acute diarrhea with duration of 14 days due to infection, drugs or poisons. Chronic or persistent diarrhea with duration of >14 days. Contraindication: Not for use in immunocompromised patients (cancer patients on chemotherapy, patients taking immunosuppressant meds) Drug Interaction: No known drug interactions.

Side Effects/Adverse Reactions: No known side effects. Adverse Effects: No known adverse effects. Nursing Responsibility: 1.) Shake drug well before administration. Allows equal distribution of the drug in the fluid it is in. 2.) Monitor patient for any unusual effects from drug. Monitoring allows detection of possible side effects of the drug since there has been no known side effect of the drug. 3.) Administer drug within 30 minutes after opening container. To avoid contamination of the drug. 4.) Dilute drug with sweetened milk, orange juice or tea. To allow easy administration of the drug. 5.) Administer drug orally. Proper administration allows better effects of the drug and prevent possible complications. Brand Name: Zinc

Suggested Dose: Typical daily doses range widely from 12 to 150 mg daily as free zinc or up to 220 mg as zinc sulfate. Mode of Action: The most common adverse reactions of oral zinc are nausea, bad taste, diarrhea, vomiting, mouth irritation, and, rarely, mouth sores. Nasal and throat irritation may occur with the zinc spray. There have been case reports of apparent zinc-induced copper deficiency, immune system dysfunction, and myeloneuropathy. An increase in genitourinary symptoms and prostate cancer has been related to zinc supplementation. Indication: Zinc has been used as a treatment for the common cold and for enhanced wound healing, but evidence to support these indications is limited. Zinc also has applications in pneumonia, diarrhea, male fertility, and Alzheimer disease.

Contraindication: None identified. Drug Interaction: Zinc may decrease the plasma concentrations of certain quinolone (eg, ciprofloxacin) and tetracycline antibiotics, as with other divalent metals, such as calcium. Interference with absorption and metabolism of iron, copper, and vitamin A has been described. Adverse Reactions: The most common adverse reactions of oral zinc are nausea, bad taste, diarrhea, vomiting, mouth

irritation, and, rarely, mouth sores. Nasal and throat irritation may occur with the zinc spray. There have been case reports of apparent zinc-induced copper deficiency, immune system dysfunction, and myeloneuropathy. An increase in genitourinary symptoms and prostate cancer has been related to zinc supplementation. Brand Name: Hidrasec Suggested Dose: Hidrasec should be given in conjunction with oral or parenteral rehydration therapy in patients where dehydration has occurred or is suspected. Hidrasec: Adults 15 years: Treatment should be initiated with a single 100-mg cap given regardless of the time. Further treatment is given approximately 8-hrly until cessation of diarrhea. The daily dose should not exceed 400 mg. If symptoms persist for >7 days, the patient should seek medical advice. Elderly: An adjustment of dose is not necessary in elderly subjects. Hidrasec Paediatric: Recommended Dose: 1.5 mg/kg body weight 3 times daily. The total daily dose should not exceed approximately 6 mg/kg.

The usual dosage according to the weight and age of the infant or child is shown in the table as follows. Use the weight of the child to calculate the dose, if this is not possible, use the age. Indication: Adjunct therapy to oral or parenteral rehydration in the treatment of acute diarrhea Contraindication: Known hypersensitivity to racecadotril or to any of the excipients of Hidrasec/Hidrasec Paediatric. As sucrose is a source of glucose and fructose, Hidrasec Paediatric should not be used in people with fructose intolerance, glucose/galactose malabsorption syndrome or sucrose-isomaltase deficiency. Drug Interaction: No specific studies in humans have been performed. Racecadotril does not inhibit or induce cytochrome P-450 in animal models. Incompatibilities: None known. Side Effects/Adverse Reactions: A few cases of drowsiness have been reported during clinical trials. Nausea and vomiting, constipation, dizziness and headache have also been reported rarely. The side effects have been mild, and equivalent in nature, frequency and intensity to those reported with placebo. There have been very rare post-marketing reports of allergic

reactions (2.9 reports/1 million adult patient exposures) including skin rashes, urticaria and angioedema. Brand Name: Trizole Suggested Dose: Childn 7-12 yr 1-11/2 tsp, 3-6 yr 1/2-1 tsp, 6 mth-2 yr 1/4-1/2 tsp. To be taken bid. Indication: Infections due to gm+ve & gm-ve bacteria, particularly acute & chronic infections of GUT, pyelitis, pyelonephritis,cystitis, prostatitis, urethritis; otit is media; Pneumocystis carinii infections. Contraindication: Hypersensitivity to sulfonamides. Severely impaired hepatic or renal function; blood dyscrasias. Porphyria. Pregnancy & lactation. Infant < 2 mth. Drug Interaction: Effects reduced by PABA & procaine-type local anesth & enhanced by highly-bound drugs. May potentiate effects of methotrexate, warfarin, sulfonylureas. View more drug interactions with Trizole Side Effects/Adverse Reactions: No known side effects.

Adverse Effects: GI disturbances; Stevens-Johnson & Lyell's syndrome. Rarely, hepatitis, blood disorders, pseudomembranous colitis.