Lovely Professional University,Punjab

Format For Instruction Plan [for Courses with Lectures and Labs

Course No PHR420T

Cours Title MEDICINAL CHEMISTRY-III

Course Planner 13522 :: Nipun Mahajan

Lectures Tutorial Practical Credits 3 0 0 3

Text Book:

1 Principles of Medicinal Chemistry William O. Foye, Thomas L. Lemke, David A. Williams Lippincott Williams & Wilkins, 2007

Other Specific Book:

Medicinal and Pharmaceutical chemistry, by Harikrishan singh & V.K.Kapoor ; Vallab Prakshan, First edition.

3 The organic Chemistry of Drug Design and Drug Action, Richard B. Silverman, Academic Press, 2004 4 Wilson and Gisvold's textbook of organic Medicinal and Pharmaceutical chemistry, Charles Owens Wilson, John H. Block, Ole Gisvold, John Marlowe Beale, Lippincott Williams & Wilkins, 2004

Other Reading Sr No Jouranls atricles as compulsary readings (specific articles, Complete reference) 5 Bhosle, D. Bharambe S., Gairola Neha, Suneela S, Dhaneshwar. Mutual prodrug concept: fundamentals and applications Indian journal of pharmaceutical Sciences. 2006, 68 (3); 286-294 6 Selvam P., Murgesh N., Chandramohan M., Debyser Z., Design, synthesis and anti HIV activity of novel Isatine-Sulphoanmides Indian J. Pharm. Sci., 2008,70 (6) : 779-782 7 Triphati Laxmi, Kumar Parveen Singhai Role of chelates in treatment of cancer 44 (2) 62-72 Relevant Websites Sr. No. (Web adress) (only if relevant to the courses) 8 http://www.arkat-usa.org/get-file/18667/ Salient Features Active antifungal substances from natural sources

Detailed Plan For Lectures

Approved for Spring Session 2011-12

Week Number Lecture Number Lecture Topic

Chapters/Sections of Pedagogical tool Textbook/other Demonstration/case reference study/images/anmatio n ctc. planned

Part 1
Week 1 Lecture 1 Drug metabolism ->Reference :4,Ch-4/142 ->Reference :1,Ch-10/253 ->Reference :4,Ch-4/142 ->Reference :1,Ch-10/253 ->Reference :4,Ch-4/144 ->Reference :5,286294 ->Reference :1,Ch-10/253 ->Reference :4,Ch-4/144 ->Reference :5,286294 ->Reference :5,286294 ->Reference :4,Ch-4/150-155 ->Reference :4,Ch-8/223 ->Reference :3,Ch-2/34 ->Reference :4,Ch-8/223 ->Reference :3,Ch-2/34 ->Reference :4,Ch-8/155 ->Reference :3,Ch-2/34 ->Reference :2,Ch35/867 Approved for Spring Session 2011-12 videos videos

Lecture 2

Drug metabolism

Lecture 3

Concepts of Prodrugs

Week 2

Lecture 4

Prodrugs of functional groups

Lecture 5

Bioprecursors Prodrugs and Chemical diversity Prodrugs

Lecture 6

Antimetabolites-oxidising agents

Week 3

Lecture 7

Antimetabolites-Cationic surfactants, Mercurials, Nucleosides analogs

model

Lecture 8

Antimetabolites-Dermatophytoses

Lecture 9

Antiprotozoal

Week 4

Lecture 10

Antiviral-anti-HIV drugs

->Reference :2,Ch-39/952 ->Reference :7,62-72

model

Part 2
Week 4 Lecture 11 Antifungal Nucleosides antifungals ->Reference :4,Ch-8/230 ->Reference :8 ->Reference :4,Ch-8/233 ->Reference :1,Ch-39/1084 ->Reference :4,Ch-38/929 ->Reference :1,Ch-42/1147 ->Reference :4,Ch-38/929 ->Reference :1,Ch-42/1147 ->Reference :1,Ch-27/323 ->Reference :4,Ch-30/718 ->Reference :1,Ch-27/323 ->Reference :4,Ch-30/718 ->Reference :1,Ch26/315 ->Reference :1,Ch26/315 ->Reference :1,Ch26/315 ->Reference :4,Ch-6/114 ->Reference :6,779782 ->Reference :4,Ch-6/116 ->Reference :6,779782 Approved for Spring Session 2011-12 Videos PPT videos

Lecture 12

Antiparasitics

model

Week 5

Lecture 13

Antineoplastics -Alkylating agents, nitrosoureas, antimetabolites

PPt

Lecture 14

Antineoplastic antitumor antibiotics, antimitotic agents

PPT

Lecture 15

Thyroid drugs

Week 6

Lecture 16

Antithyriod drugs

Lecture 17 Lecture 18 Week 7 Lecture 19 Lecture 20

Insulin oral hypoglycaemic agents Oral hypoglycaemic agents Peptidomimetics

Lecture 21

Nucleomimetics

MID-TERM Part 3
Week 8 Lecture 22 Lecture 23 Lecture 24 Week 9 Lecture 25 Lecture 26 Lecture 27 Week 10 Lecture 28 Lecture 29 Diagnostic agents Radiographic contrast media Diagnostic agents-dyes, inulin ->Reference :1,Ch-43 ->Reference :1,Ch-43 ->Reference :1,Ch-43 ->Reference :1,Ch-43 Videos PPT

Diagnostic agents-Histamine phosphate and related ->Reference :1,Ch-43 compounds Pharmaceutical aids-preservatives Pharmaceutical aids-antioxidants Pharmaceutical aids-colouring agents ->Reference :1,Ch-46 ->Reference :1,Ch-46 ->Reference :1,Ch-46

Animations

Part 4
Week 10 Week 11 Lecture 30 Lecture 31 Lecture 32 Lecture 33 Week 12 Lecture 34 Lecture 35 Lecture 36 Week 13 Lecture 37 Lecture 38 Lecture 39 flavouring agents Pharmaceutical aids- sweetening agents Emulsifying agents Ointment bases solvents Vehicles Immunostimulants Immunostimulants Immunosuppressants Immunosuppressants ->Reference :1,Ch-46 ->Reference :1,Ch-46 ->Reference :1,Ch-46 ->Reference :1,Ch-46 ->Reference :1,Ch-46 ->Reference :1,Ch-46 ->Reference :1,Ch-46 ->Reference :1,Ch-46 ->Reference :1,Ch-46 ->Reference :1,Ch-46 animations animations Pharmaceutical prepreations

Spill Over
Week 14 Lecture 40 Lecture 41 Thyroid drugs Antiparasitics ->Reference :1,Ch27/323 ->Reference :4,Ch8/233

Approved for Spring Session 2011-12

Approved for Spring Session 2011-12