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Elastic fiber
From Wikipedia, the free encyclopedia
Elastic fibre Elastic fibres (or yellow fibres) are bundles of proteins (elastin) found in extracellular matrix[1] of connective tissue and produced by fibroblasts and smooth muscle cells in arteries. These fibers can stretch up to 1.5 times their Subcutaneous tissue from a young rabbit. Highly magnified. (Elastic fibers labeled at right. ) length, and snap Gray's subject #104 377 (http://education.yahoo.com/reference/gray/subjects/subject?id=104#p377) back to their original length when relaxed. Elastic fibers include elastin, elaunin and oxytalan.
Elastic tissue is classified as "connective tissue proper".[2] The elastic fiber is formed from the elastic microfibril (consisting of numerous proteins such as microfibrillar-associated glycoproteins, fibrillin, fibullin, and the elastin receptor) and amorphous elastin. The microfibril scaffolds and organizes the deposition of amorphous elastin. Amorphous elastin forms from monomers of soluble tropoelastin which is insolubilized and crosslinked into amorphous elastin by lysyl oxidase. Lysyl oxidase reacts with specific lysine residues and by oxidative deamination generates reactive aldehydes and allysine. These reactive aldehydes and allysines can react with lysine and other allysine residues to crosslink and form desmosine, isodesmosine, and a number of other polyfunctional crosslinks that join surrounding elastin molecules to build an elastin matrix and elastic fiber. These unique crosslinks are responsible for elastin's elasticity.
Contents
1 Distribution 2 Histology 3 Defects and disease 4 See also 5 References 6 External links
Distribution
Elastic fibers are found in the skin, lungs, arteries, veins, connective tissue proper, elastic cartilage, periodontal ligament, fetal tissue and other structures.
Histology
Elastic fibers stain well with aldehyde fuchsin, orcein,[3] and Weigert's elastic stain in histological sections. The permanganate-bisulfite-toluidine blue reaction is a highly selective and sensitive method for demonstrating elastic fibers under polarizing optics. The induced birefringence demonstrates the highly ordered molecular structure of the elastin molecules in the elastic fiber. This is not readily apparent under normal optics.
See also
Elastic artery
References
1. ^ Liu X, Zhao Y, Gao J, et al. (February 2004). "Elastic fiber homeostasis requires lysyl oxidase-like 1 protein". Nat. Genet. 36 (2): 17882. doi:10.1038/ng1297 (http://dx.doi.org/10.1038%2Fng1297) . PMID 14745449 (http://www.ncbi.nlm.nih.gov/pubmed/14745449) . 2. ^ Strum, Judy M.; Gartner, Leslie P.; Hiatt, James L. (2007). Cell biology and histology. Hagerstwon, MD: Lippincott Williams & Wilkins. p. 83. ISBN 0-7817-8577-4. 3. ^ "Connective Tissue" (http://www.courseweb.uottawa.ca/medicinehistology/English/SS_BasicTissues/Connective_Tissue.htm) . http://www.courseweb.uottawa.ca/medicinehistology/English/SS_BasicTissues/Connective_Tissue.htm.
External links
Histology at BU 00801ooa (http://www.bu.edu/histology/p/00801ooa.htm) - "Connective Tissue elastic fibers " UIUC Histology Subject 328 (https://histo.life.illinois.edu/histo/atlas/oimages.php?oid=328) Elastic+fibers (http://www.emedicinehealth.com/script/main/srchcont_dict.asp?src=Elastic+fibers) at eMedicine Dictionary Organology at UC Davis TermsCells&Tissues/connective/elastic/elastic2 (http://trc.ucdavis.edu/mjguinan/apc100/modules/TermsCells&Tissues/connective/elastic/elastic2.html) - "Connective tissue, elastic (LM, High)"
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