Drug

Indication

Action

Side effect/Adverse Reaction

Nursing Consideration/Patient Teachings

 Monitor BP for therapeutic effectiveness. BP reduction is greatest after peak levels of amlodipine are achieved 69 h following oral doses.  Monitor for S&S of doserelated peripheral or facial edema that may not be accompanied by weight gain; rarely, severe edema may cause discontinuation of drug. Monitor BP with postural changes. Report postural hypotension. Monitor more frequently when additional antihypertensives or  diuretics are added. Monitor heart rate; doserelated palpitations (more common in women) may occur. Report significant swelling of face or extremities. Report shortness of breath, palpitations, irregular heartbeat, nausea, or constipation to physician.  Avoid getting up too fast from a sitting or lying position, or you may feel dizzy. Get up slowly and steady yourself to prevent a fall.

Date Ordered: June 28, 2011 Generic Name: Amlodipine Brand Name:

Hypertension

Inhibits influx of calcium ion across cell membranes to produce relaxation of coronary vascular smooth muscle (dilation of coronary arteries), decrease peripheral vascular resistance of smooth muscle (decrease blood pressure) and increases myocardial oxygen delivery in patients with vasospastic angina.

CV: arrhythmia (including ventricular tachycardia and atrial fibrillation), bradycardia, chest pain, hypotension, tachycardia, postural dizziness, postural hypotension. CNS: paresthesia, tremor, vertigo. ANS: dry mouth, sweating increased GI: anorexia, constipation, dyspepsia, dysphagia, diarrhea, flatulence, pancreatitis, vomiting. Hemopoietic: leukopenia, purpura, thrombocytopenia.

Classification: Cardiovascular Agents | Calcium Channel Blocker Dosage: 5mg/tab | O.D (pm)

 

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Amlodipine relaxes peripheral and coronary vascular smooth muscle. It produces coronary vasodilation by inhibiting the entry of Ca ions into the voltage-sensitive channels of the vascular smooth muscle and myocardium during depolarisation. It also increases myocardial O2 delivery in patients with vasospastic angina. Absorption: Well absorbed from the GI tract (oral); peak plasma concentrations after 6-12 hr. Distribution: Protein-binding: 97.5%. Metabolism: Hepatic: Extensive. Excretion: Via urine (mainly as metabolites, 10% as unchanged); 35-50 hr (elimination half-life). C08CA01 - Amlodipine ; Belongs to the class of dihydropyridine derivative selective calcium-channel blockers with mainly vascular effects. Used in the treatment of cardiovascular diseases. Amlodipine is in a group of drugs called calcium channel blockers. Amlodipine relaxes (widens) blood vessels and improves blood flow. Amlodipine is used to treat high blood pressure (hypertension) or chest pain (angina) and other conditions caused by coronary artery disease. This medication is for use in adults and children who are at least 6 years old. Amlodipine may also be used for other purposes not listed in this medication guide.

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