FORMULATION AND EVALUATON OF MICROEMULSION OF NON-STEROIDAL ANTI- INFLAMMATORY DRUG SYNOPSIS FOR M.

PHARM DISSERTATION

SUBMITTED TO RAJIV GANDHI UNIVERSITY OF HEALTH SCIENCES KARNATAKA BY M.SUNEETHA I M.PHARM UNDER THE GUIDANCE OF MR.S.RAJARAJAN ASSISTANT PROFESSOR

DEPARTMENT OF PHARMACEUTICAL TECHNOLOGY KARNATAKA COLLEGE OF PHARMACY BENGALURU-560064 (2011-2012)

RAJIV GANDHI UNIVERSITY OF HEALTH SCIENCES KARNATAKA, BANGALORE. ANEXURE-II PROFORMA FOR REGISTRATION OF SUBJECTS FOR DISSERTATION

Name of the Candidate and Address M.SUNEETHA KARNATAKA COLLEGE OF PHARMACY #33/2, THIRUMENAHALLI HEGDE NAGAR MAIN ROAD BANGALORE-560064 PERMANENT ADDRESS M.SUNEETHA D/O M.BALI REDDY DOOR NO:13-5-20 GUNTUR VARI THOTA 4TH LANE, GUNTUR. ANDHRAPRADESH. Karnataka College of Pharmacy #33/2, Thirumenahalli Hegde Nagar Main Road Bangalore-560064

Name of the Institute

Course of the Study & Subject

MASTER OF PHARMACY (PHARMACEUTICAL TECHNOLOGY)

Date of the Admission to the Course

July 28th 2011

Title of the topic: FORMULATION AND EVALUATION OF MICROEMULSION OF NON-STERIODAL ANTI-INFLAMMATORY DRUG

6 6.1

BRIEF RESUME OF THE INTENDED WORK:-TIVIT Need for Study: Topical medications are applied directly to the skin. There are different classes of topical drug delivery system and they are as follows: lotion, ointment, cream, gel, emulsions. In use it may be highly advantageous, such as with the described topical anesthetic device, to instruct the patient to apply the device to a target skin surface location. Some of the examples of topical are: Anti-fungal agents, Eutectic mixture, etc. In Transdermal drug delivery (TDDS) because of their high drug loading capacity they can provide higher concentration gradient, thus increasing driving force across the skin. Micro emulsion has low interfacial tension and will allow excellent contact with skin surface, with the vehicle filling even wrinkles and microscopic gaps. This enhances the vehicle skin drug transfer. They have been used to improve the bioavailability of various poorly soluble drugs including Non-steroidal anti-inflammatory drugs (NSAIDs) Micro emulsions avoid first pass metabolism, and their ease of administration with good control over rate of drug delivery. In topical formulations they have been proved to increase the cutaneous absorption of both lipophilic and hydrophilic APIs. In this type of applications the micro emulsions attribute to the performance to generally a higher solubility of the APIS of micro emulsions, generating increased concentration gradient towards skin. Micro emulsions are isotropic, thermodynamically stable transparent system of oil, water and surfactant, frequently in combination with a co-surfactant. Their size generally range from 10-200nm. They can be classified as oil-in-water (o/w), water-in-oil (w/o) or bicontinuous systems depending on their structure and are characterized by ultra low interfacial tension between oil and water phases. Topical application of NSAIDs on the inflamed site can offer the advantage of delivering a drug directly to the disease site and producing its local effect. NSAIDs have been widely used in the treatment of rheumatoid arthritis and other related conditions. The present dissertation work is to develop an NSAID micro emulsion adaptable transdermal delivery systems which provides protection against oxidation, fast absorption, thereby balances bioavailability, prolonged release and enables reduction in dose.The current research work is focused to formulate and evaluate the micro emulsions using an ideal topical drug candidate of NSAIDs by suitable method with its release and stability studies.

6.2

Review of Literature:

Gives review on micro emulsions, which are clear, stable, isotropic mixtures of oil, water and surfactant, frequently in combination with a co surfactant. These systems are currently of interest to the pharmaceutical scientist because of their considerable potential to act as drug delivery vehicles by incorporating a wide range of drug molecules. The use of micro emulsions and closely related micro emulsions-based