Pharmacy Paper I Marks100 (a) Chemical bonds: Electronic concept of valency, different types of chemical bonds, theories of covalent

bonding and hybridisation. (b) pH and buffer: Determination of pH of acids and bases, salt solutions and buffers. Preparation of buffers. Buffers in pharmaceutical and biological systems. (c) Principles and applications of absorption spectroscopy such as UVVisible spectrophotometry, nuclear magnetic resonance spectroscopy and mass spectrometry. (d) Separation techniques: Basic principles of chromatography, layer chromatography, ion exchange chromatography, gas chromatography, gas liquid chromatography and high performance liquid chromatography. Applications of chromatography in pharmaceutical fields. (e) Quality control and quality assurance: Method validation, calibration, SOP and CGMP. (f) Chemistry, SAR and mechanism of action and pharmacological properties of individual class of drugs. (i) Analgesics and antiinflammatory agents. (ii) Antihistamines. (iii) Antibiotics. (iv) Antihypertensive agents. (v) Antidiabetic drugs. (g) Vitamins and antioxidants: Classification and uses of vitamin preparations. Properties and uses of antioxidants. Pharmacy PaperII Marks100 (a) Pharmaceutical dosage forms. (i) Tablets: Manufacturing of tablets by wet granulation, dry granulation and direct compression, advantages and disadvantages of different processes, common tableting problems and evaluation of tablets. (ii) Capsules: Classification, advantages and limitations of capsule dosage form, properties of capsules, formulation of capsules, problems in capsule manufacturing, quality control of capsules. (iii)Suspensions: Advantages and disadvantages, aggregated and dispersed systems, formulation of suspensions, stability of suspension, quality analysis of suspension. (iv) Emulsions: Applications, advantages and disadvantages, theory of emulsion, formulation of emulsion, classification of emulsifying agents, HLB values of surface active agents,

quality analysis of emulsion. (vi)Sustained release drug delivery systems: Principle of SR dosage forms, advantages and limitations of SR dosage forms, classification and types of SR dosage forms, drug release mechanisms from SR dosage forms, dose calculation for SR dosage forms. (vii) Parenteral products: Classification of parenteral products. Formulation considerations. Vehicles, additives and containers. (b) Skin creams and dental products: Introduction, classification and formulation of skin creams. Anticaries and antiplaque agents. Properties and types of dentifrices, formulation of powder dentifrices and pasts. (c) Biopharmaceutical consideration: pKa and gastrointestinal absorption, important pharmacokinetic parameters such as biological half life, apparent volume of distribution, area under the curve, elimination rate constant etc. First pass effect, bioavailability and bioequivalence studies. (d) Pharmacy act, new drug policy of government, drug act, drug rules, poison act, poison rules, dangerous drug act and dangerous drug rules as in force in Bangladesh