Improved periodontal health and cardiovascular risk.

Authors: Rose-Hill, S1 Ford, PJ1 Leishman, SJ2 Do, HL2 Palmer, JE2 Heng, NCK3 West, MJ2 Seymour, GJ2,3 Cullinan, MP2,3 Source: Australian Dental Journal; Dec2011, Vol. 56 Issue 4, p352-357, 6p Document Type: Article Subject Terms: PERIODONTAL disease PORPHYROMONAS gingivalis CARDIOVASCULAR system -- Diseases MOUTH -- Diseases GUMS -- Diseases PERIODONTITIS DENTISTRY Abstract: Background: Previous studies have demonstrated variable effects on systemic inflammatory and immune responses following improved periodontal health. This study examined changes in serum levels of the inflammatory mediators IL-1, IL-6, TNF- and sICAM-1, and antibodies to Porphyromonas gingivalis, human heat shock protein (hHSP) 60 and P. gingivalis GroEL following improvement in periodontal health in high cardiovascular (CV) risk and low CV-risk patients. Methods: Patients retrospectively selected from a longitudinal study, had undergone yearly periodontal examinations and peripheral blood collections. They had demonstrated a quantifiable improvement in periodontal health (>60% reduction in number of sites with probing depth 4 mm from the baseline visit) and could be classified as either high CV-risk (6 classical risk factors, n = 13) or low CV-risk (1 classical risk factor, n = 14). Serum levels of the cytokines and antibodies were measured using ELISA. Results: For sICAM-1 and anti- P. gingivalis GroEL and anti-hHSP60 antibodies, most patients recorded decreased levels. Reductions in serum sICAM-1 levels were more notable in low CV-risk patients (p = 0.006); and reductions in levels of anti- P. gingivalis GroEL and anti-hHSP60 antibodies (p = 0.001 and 0.009 respectively) were more notable in high CV-risk patients. Conclusions: This study found that subsequent to improved periodontal health, the antiHSP (HSP60 and GroEL) antibody response was reduced, particularly for high CV-risk patients. sICAM-1 levels were also lowered, more so for low CV-risk patients. [ABSTRACT FROM AUTHOR]

Copyright of Australian Dental Journal is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) Author Affiliations: 1 School of Dentistry, The University of Queensland, Brisbane, Australia. 2 School of Medicine, The University of Queensland, Brisbane, Australia. 3 Faculty of Dentistry, The University of Otago, Dunedin, New Zealand. ISSN: 00450421 DOI: 10.1111/j.1834-7819.2011.01363.x Accession Number: 67510388 Database: Dentistry & Oral Sciences Source
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Novel Endothelial Biomarkers: Implications for Periodontal Disease and CVD.

Authors: Li, X.1 Tse, H.F.2 Jin, L.J.3 Source: Journal of Dental Research; Sep2011, Vol. 90 Issue 9, p1062-1069, 8p, 3 Diagrams, 2 Charts Document Type: Article Subject Terms: ENDOTHELIUM BIOCHEMICAL markers PERIODONTAL disease CARDIOVASCULAR system -- Diseases INFLAMMATION PERIODONTIUM -- Infections GINGIVITIS PERIODONTITIS NITRIC oxide Author-Supplied Keywords: endothelial cells inflammation periodontal disease progenitor cells Abstract: Endothelial cells are actively involved in various aspects of vascular biology and different stages of atherosclerosis. Endothelial function is increasingly used as an important outcome measure in cardiovascular research. Endothelial progenitor cells (EPCs) are closely linked to endothelial function, and their biomarkers have received much attention. EPCs may not only serve as a pool of progenitor cells and possess the capacity to repair the damaged vasculature, but also act as potent effectors in systemic inflammation, suggesting that EPCs may play a critical role in maintaining endothelial function and the progression of cardiovascular disease (CVD). Emerging evidence shows an association of periodontal infections (gingivitis and periodontitis) with endothelial dysfunction, while the relevant mechanisms remain unknown. Our recent finding of the association of periodontitis with EPCs warrants their utilization as additional biomarkers in future studies on periodontal medicine. This review starts with a brief account on the current understanding of the nature of periodontal infections and their link with systemic inflammation and endothelial dysfunction. The paper also provides an update on endothelial biology and function as well as the novel biomarkers of EPCs and concludes with clinical studies on periodontal diseases and CVD. [ABSTRACT FROM PUBLISHER]

Copyright of Journal of Dental Research is the property of Sage Publications Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) Author Affiliations: 1 Faculty of Dentistry, Periodontology, The University of Hong Kong, 34 Hospital Road 2 Cardiology Division, Department of Medicine, Queen Mary Hospital, The University of Hong Kong, Pokfulam Road, Hong Kong SAR, China 3 Faculty of Dentistry, Periodontology, The University of Hong Kong, 34 Hospital Road ljjin@hkucc.hku.hk ISSN: 00220345 DOI: 10.1177/0022034510397194 Accession Number: 66816435 Database: Dentistry & Oral Sciences Source