1. Neutralization of transforming growth factor (TGF-) is most likely to affect which of the following steps in the inflammatory-repair response?

? 2. A 60-year-old woman suffered an acute myocardial infarction involving a 3 4 cm area of the posterior left ventricular free wall. Creatine kinase was elevated to 600 U/L in her serum. She was treated for arrhythmias and decreased cardiac output while in the hospital A month later. Which of the following pathologic finding would you most expect to find in her left ventricle? 3. After viral hepatitis there is usually complete recovery of the normal liver architecture. In contrast a healed liver abscess caused by bacteria leaves a scars in the liver. Which of the following factors best explains the different outcomes for the two different forms of liver injury? 4. A 23-year-old female receiving corticosteroid therapy for an autoimmune disease has an abscess on her upper outer right arm. She undergoes minor surgery to incise and drain the abscess, but the wound heals poorly over the next month. Which of the following aspects of wound healing is most likely to be deficient in this patient? 5. A cesare an section is performed on a 20-year-old woman to deliver a term infant, and the lower abdominal incision is sutured. The sutures are removed 1 week later. Which of the following statements best describes the wound site at the time of suture removal? For each of the description of the descriptions of the wound healing process in questions 6 and 7, mach the most closely associated lettered substance: 6. During remodeling of scars metallopreoteinases degrade extracellular matrix components. This action of metalloproteinases is diminished because of the lack of this substance? 7. Intracytopasmic cytoskeletal elements, including actin, interact with the extracellular matrix through this molecule to provide cell attachment and migration in wound healing? 8. Release of epidermal growth factor into an area of denuded skin causes mitogenic stimulation of the skin epithelial cells. Which of the following proteins is most likely to be involved in transducing the mitogenic signal from the epidermal cell membrane to the nucleus? 9. During growth factorinduced cellular regeneration, which of the following transitions during cell cycle is controlled by phosphorylation of the retinoblastoma (Rb) protein: 10. Which of the following molecules synthesized by fibroblasts can best bind to cellular integrants and extracellular collagen and attach epidermal basal cells to basement membrane? 11. A alceration to the left hand of an 18-year-old man lacerated his left hand and required sutures and after the sutures were removed 1 week later and healing continued. However, the side of the wound became disfigured by a prominent raised, nodular scar that developed over the next 2months. What process ocurred?

12. During the healing of a skin ulcer. Which of the following factors is most effective in promoting angiogenesis? 13. The appearance of the trichrome-stained section of a surgical wound site in the figure is most likely to be seen how long after surgery? 14. A 50-year-old woman tests positive for hepatitis A antibody, the serum aminotransferase (AST) level is 275 U/L, and that alanine aminotransferase ( ALT) was 310 U/L. One month later, these enzyme levels have returned to normal, in which part of the cell cycle are most of the hepatocytes going to be? 15. A 40-year-old man underwent laparotomy for a perforated sigmoid colon diverticulum. A wound infection complicated the postoperative course, and surgical wound dehiscence occurred. Primary closure was no longer possible, and the wound granulated in. Six weeks later, the wound is only 10% of its original size. Which of the following processes best accounts for the observed decrease in wound size?