PATHOLOGY NOTES
DR. GOLJAN
GENERAL PATHNote: Tihis material is copyrighted. All rights reserved
TABLE OF CONTENTS FOR GENERAL
PATHOLOGY NOTES
Prepared by Edward Goljan, M.D.
Subject i : Pages —
General Principles of Lab Medicine 1-8
Cell Injury i 19-2 |
Inflammation
Immunopathology
Fluids and Hemodynamics/Acid-Base 60-92
| Nutrition 7 7 193-1 17
Genetics —_ a 118-158
1159-186
Te
8
Environmental Pathology
JeoplasiaNote: This material is copyri
GOLJAN HIGH YIELD NOTES FOR USMLE STEP 1
Note: Thi is copyrighted. All rights reserved. No part of this publication may i
ny form or by any menns, electror mechanical. includin cording, or fi
storage and retrieval system, without permission in writing from the publisher (Edward F. Galjan, M.L
tions commonly used: AD = autosomal dominam, AR = autosomal recessive, COD = ¢
= diagnosis, MC = most common, MCC = most common cause, Rx = treatment, S/S = si
High Yield Concepts in General Pathology
General Principles of Lab Medicine
Sensitivity of a test
positivity in disease
A. TP = patient with the dise
B. FN =patient with diseas ve test rest
CC. formula for sensitivity TP
use of a test with 100 % sensitivity
A. best used to sereen for discas
B. excludes disease wh tive
C._ ineludes people with ¢
D. catch words: exclud
3. interpretation of a test with 100% sensitivity when it returns normal in a patient
TN/TN+EN)
disease) since there are no FNs: a TN is a true
fe or a normal test result in a person without disease
rum ANA has 100% sensitivity for SLE: a
interpretation of a test with 100% sensitivity when it returns positive in a patient
\, may be a TP or FP:
gative serui
(1) FP= false positive or a positive test result in a normal person
note that FPs are not in the formula for sensitivity
5 ne disease are always included
@.g., a positive serum ANA result includes all people with SLE: it does not confirm SLE
° since other diseases also have a positive ANA (e.g., rheumatoid arthritis, progressiv
a Disease No Disease
Positive test (TP) 100 (FP) 10
5 Negative test. (FN) 0 (TN) 90
@ Calculate sensitivity of the test; TP / TP + FN = 100/ 100 Loo»
@ Calculate PV: TN / TN + FN =90 /90+0-= 1008
Specificity of a test
1. "negativity in health
A. TN = normal test result in a person without disease
B. FP = patient without disease who has a positive res!